Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 7,500 | |||
5 mg | 在庫あり | ¥ 16,000 | |||
10 mg | 在庫あり | ¥ 26,000 | |||
25 mg | 在庫あり | ¥ 60,500 | |||
50 mg | 在庫あり | ¥ 96,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 25,000 |
説明 | Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ). |
In vivo | Palovarotene effectively hinders post-traumatic chondrogenesis, osteogenesis, and significantly reduces trauma-induced ectopic bone formation. Through oral administration (1 mg/kg/day for 14 days, starting from either the first or fifth day post-operation), this compound markedly decreases subcutaneous and intramuscular heterotopic ossification (HO) in mice, achieving a reduction of 50 to 60% in HO, irrespective of treatment initiation timing or infection presence. In a specific study, Acvr1cR206H/+ mice were divided into two groups: one treated with Palovarotene and the other with a vehicle control for 14 days beginning on the injury's first day. Comparative analysis using micro-CT and 3D imaging on the 14th day revealed that while significant HO tissue masses developed in the vehicle-treated group, Palovarotene-treated mice showed over an 80% reduction in HO formation, based on bone volume/total volume metrics. |
別名 | Ro 3300074, R 667 |
分子量 | 414.54 |
分子式 | C27H30N2O2 |
CAS No. | 410528-02-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.5 mg/mL (13.27 mM)
You can also refer to dose conversion for different animals. 詳細
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palovarotene 410528-02-8 Autophagy Metabolism Retinoid Receptor RAR/RXR inhibit Retinoid X receptors R667 Ro 3300074 R 667 Ro-3300074 Retinoic acid receptors Inhibitor R-667 Ro3300074 inhibitor