Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RP-6306 is a potent, selective and orally active PKMYT1 inhibitor (IC50= 14 nM). RP-6306 exhibits a high degree of selectivity for PKMYT1 over other kinases in cellular binding assays. RP-6306 exhibits anticancer effects.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 52,500 |
5 mg | 在庫あり | ¥ 133,000 |
10 mg | 在庫あり | ¥ 191,500 |
25 mg | 在庫あり | ¥ 291,500 |
50 mg | 約6-8 週間 | ¥ 388,000 |
100 mg | 約6-8 週間 | ¥ 525,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 135,000 |
説明 | RP-6306 is a potent, selective and orally active PKMYT1 inhibitor (IC50= 14 nM). RP-6306 exhibits a high degree of selectivity for PKMYT1 over other kinases in cellular binding assays. RP-6306 exhibits anticancer effects. |
ターゲット&IC50 | PKMYT1:14 nM |
In vitro | RP-6306 (500 nM; 24h) treatment induced pan-γH2AX in HCC1569 breast cancer cell line indicates that tumor derived CCNE1 amplification also makes cells susceptible to DNA damage induction after PKMYT1 inhibition. RP-6306 treatment can selectively and accidentally activate CDK1 in CCNE1 overexpression cells, thus promoting early mitosis of cells undergoing DNA synthesis [2]. |
In vivo | In the ovarian xenograft model (OVCAR3) amplified by CCNE1, RP-6306 (15, 50, and 300 ppm; oral; daily; for 21 days) significantly reduced tumor growth in OVCAR3 in a dose-dependent manner [1]. |
別名 | (S)-RP-6306 |
分子量 | 324.38 |
分子式 | C18H20N4O2 |
CAS No. | 2719793-90-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (138.7 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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RP-6306 2719793-90-3 Cell Cycle/Checkpoint Wee1 RP 6306 RP6306 (S)-RP-6306 Inhibitor inhibitor inhibit