Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB-747651A dihydrochloride is a chemical compound that serves as an ATP-competitive inhibitor for mitogen- and stress-activated kinase 1 (MSK1), featuring an IC50 of 11 nM. Additionally, this compound effectively inhibits PRK2, RSK1, p70S6K, and ROCK-II, showcasing its potential in inflammation research [1].
説明 | SB-747651A dihydrochloride is a chemical compound that serves as an ATP-competitive inhibitor for mitogen- and stress-activated kinase 1 (MSK1), featuring an IC50 of 11 nM. Additionally, this compound effectively inhibits PRK2, RSK1, p70S6K, and ROCK-II, showcasing its potential in inflammation research [1]. |
In vitro | SB-747651A dihydrochloride (5 μM; neutrophils) modulates neutrophil behavior in response to the CXCL2 chemotactic gradient in various ways. It influences CXCL2-induced intraluminal crawling of neutrophils in a Mac-1-dependent manner, obstructing the movement of adherent neutrophils to optimal emigration sites. Furthermore, it notably prolongs the transmigration and detachment times of neutrophils, indicating a significant impact on the mechanisms overseeing their transendothelial migration. Additionally, while SB-747651A dihydrochloride slows the migration velocity of extravascular chemotaxing neutrophils, it does not alter their directionality towards CXCL2 signals. |
In vivo | SB747651A (3 mg/kg; intrascrotal injection) dihydrochloride has been shown to significantly increase neutrophil adhesion between 3.5 and 4.5 hours after stimulation with CXCL2, in comparison to the effect solely attributable to CXCL2 [3]. Additionally, the same compound administered intraperitoneally (i.p.) at the same dosage enhanced neutrophil extravasation, specifically by augmenting neutrophil emigration at the 3 and 4-hour marks within a mouse peritonitis model for acute inflammation [3]. The experiments were conducted using male C57BL/6N mice aged between 8 to 16 weeks, establishing that a 3 mg/kg dosage, when given as an intrascrotal injection, effectively results in heightened neutrophil adhesion subsequent to CXCL2 stimulation. |
分子量 | 415.32 |
分子式 | C16H24Cl2N8O |
CAS No. | 1781882-72-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (120.39 mM)
You can also refer to dose conversion for different animals. 詳細
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SB-747651A Dihydrochloride 1781882-72-1 Cell Cycle/Checkpoint Cytoskeletal Signaling Stem Cells ROCK SB747651A Dihydrochloride SB 747651A Dihydrochloride SB-747651A Inhibitor inhibitor inhibit