Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA2, FFA3 and the nuclear receptor PPARγ, as well as other different receptors, ion channels and transporter proteins.TUG-499 can be used to study type 2 Type 2 diabetes.
説明 | TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA2, FFA3 and the nuclear receptor PPARγ, as well as other different receptors, ion channels and transporter proteins.TUG-499 can be used to study type 2 Type 2 diabetes. |
ターゲット&IC50 | FFAR1/GPR40:7.39(pEC50) |
In vitro | TUG-499 exhibits remarkable chemical stability, does not inhibit specific CYP enzymes or P-glycoprotein, and displays outstanding Caco-2 permeability. Its potent effects are observed on recombinant human FFA1 receptors as well as the INS-1E rat insulinoma cell line.[1] |
分子量 | 320.17 |
分子式 | C16H11Cl2NO2 |
CAS No. | 1206629-08-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (70.28 mM)
You can also refer to dose conversion for different animals. 詳細
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TUG-499 1206629-08-4 DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Metabolism GPR PPAR TUG 499 TUG499 Inhibitor inhibitor inhibit