Co-inhibitory Immune Checkpoint Proteins

Inhibitory checkpoint molecules play an important role in the maintenance of immune homeostasis: their expression on effector T cells ensures the proper contraction of effector T cell responses; their expression on regulatory T (Treg) cells promotes the suppressive function of Tregs. Blockade of inhibitory immune checkpoint molecules has proven to enhance immune responses to various cancers and exhibit remarkable clinical efficacy in cancer treatment.

カタログ番号	製品名 / Synonyms	Species	Expression System
TMPY-02476	CD96 Protein, Mouse, Recombinant (His) CD96 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-02476	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-00996	PD-1 Protein, Mouse, Recombinant (His) PD-1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-00996	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively reg...
TMPY-04262	B7-H3 Protein, Human, Recombinant (His), Biotinylated B7-H3 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
TMPY-04262	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-05815	PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated	Canine	HEK293
TMPY-05815	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively reg...
TMPY-05227	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
TMPY-05227	Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on ...
TMPY-05276	CD47 Protein, Cynomolgus, Recombinant (hFc) CD47 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
TMPY-05276	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in mem...
TMPY-00674	B7-1 Protein, Human, Recombinant B7-1 Protein, Human, Recombinant	Human	HEK293
TMPY-00674	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ...
TMPY-05372	FGL1 Protein, Human, Recombinant (His) FGL1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
TMPY-05372	FGL1 Protein, Human, Recombinant (His) is expressed in Baculovirus-Insect Cells with His tag. The predicted molecular weight is 35.5 kDa. Accession number: Q0883...
TMPY-02031	B7-H3 Protein, Human, Recombinant (His) B7-H3 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-02031	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-04683	CD47 Protein, Human, Recombinant CD47 Protein, Human, Recombinant	Human	HEK293
TMPY-04683	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in mem...
TMPY-04949	PD-L1 Protein, Human, Recombinant (His), Biotinylated PD-L1 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
TMPY-04949	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been ...
TMPY-04345	PD-L1 Protein, Rat, Recombinant (His) PD-L1 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-04345	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been ...
TMPY-04064	B7-H3 Protein, Mouse, Recombinant (His) B7-H3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-04064	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-04957	PD-L2 Protein, Human, Recombinant (His), Biotinylated PD-L2 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
TMPY-04957	Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and ...
TMPY-04730	LAG-3 Protein, Human, Recombinant (His) LAG-3 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-04730	LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte acti...
TMPY-01612	CD155/PVR Protein, Rhesus, Recombinant (His) CD155/PVR Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
TMPY-01612	CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne...
TMPY-05322	B7-H4 Protein, Mouse, Recombinant (His) B7-H4 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-05322	V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 f...
TMPY-05260	PD-1 Protein, Cynomolgus, Recombinant (His) PD-1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
TMPY-05260	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively reg...
TMPY-01180	CD86 Protein, Human, Recombinant (His) CD86 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01180	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan...
TMPY-06094	PVRIG Protein, Cynomolgus, Rhesus, Recombinant (His) PVRIG Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293
TMPY-06094	PVRIG Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 15.3 kDa. Accession number: XP_005549...