Co-inhibitory Immune Checkpoint Proteins

Inhibitory checkpoint molecules play an important role in the maintenance of immune homeostasis: their expression on effector T cells ensures the proper contraction of effector T cell responses; their expression on regulatory T (Treg) cells promotes the suppressive function of Tregs. Blockade of inhibitory immune checkpoint molecules has proven to enhance immune responses to various cancers and exhibit remarkable clinical efficacy in cancer treatment.

カタログ番号	製品名 / Synonyms	Species	Expression System
TMPY-03219	VISTA Protein, Human, Recombinant (His) VISTA Protein, Human, Recombinant (His)	Human	HEK293
TMPY-03219	VSIR (V-Set Immunoregulatory Receptor, also known as VISTA) is a Protein Coding gene. VISTA is an immunoregulatory receptor that inhibits the T-cell response. It...
TMPY-01604	CTLA-4 Protein, Mouse, Recombinant (His) CTLA-4 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-01604	Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is t...
TMPY-04898	PD-1 Protein, Human, Recombinant (hFc) PD-1 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-04898	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively reg...
TMPY-04939	LAG-3 Protein, Human, Recombinant LAG-3 Protein, Human, Recombinant	Human	HEK293
TMPY-04939	LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte acti...
TMPY-00237	PD-L1 Protein, Canine, Recombinant (hFc) PD-L1 Protein, Canine, Recombinant (hFc)	Canine	HEK293
TMPY-00237	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been ...
TMPY-02669	TIGIT Protein, Mouse, Recombinant (His) TIGIT Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-02669	TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface...
TMPY-03670	PD-L1 Protein, Cynomolgus/Rhesus, Recombinant (His) PD-L1 Protein, Cynomolgus/Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293
TMPY-03670	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been ...
TMPY-05395	PD-1 Protein, Mouse, Recombinant (hFc) PD-1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
TMPY-05395	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively reg...
TMPY-01155	PD-L1 Protein, Mouse, Recombinant (His) PD-L1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-01155	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been ...
TMPY-01386	CD155/PVR Protein, Human, Recombinant (His) CD155/PVR Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01386	CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne...
TMPY-04824	CTLA-4 Protein, Human, Recombinant CTLA-4 Protein, Human, Recombinant	Human	HEK293
TMPY-04824	Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is t...
TMPY-00699	CD155/PVR Protein, Human, Recombinant (hFc) CD155/PVR Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-00699	CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne...
TMPY-03524	B7-H4 Protein, Human, Recombinant (His) B7-H4 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-03524	V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 f...
TMPY-00897	PD-1 Protein, Human, Recombinant (His) PD-1 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-00897	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively reg...
TMPY-04346	PD-L2 Protein, Human, Recombinant (His) PD-L2 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-04346	Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and ...
TMPY-03093	CD47 Protein, Rat, Recombinant (His) CD47 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-03093	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in mem...
TMPY-01302	CD200R Protein, Human, Recombinant (His) CD200R Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01302	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-04810	CD47 Protein, Mouse, Recombinant (His) CD47 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-04810	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in mem...
TMPY-04935	CD47 Protein, Human, Recombinant (aa 1-139, His) CD47 Protein, Human, Recombinant (aa 1-139, His)	Human	HEK293
TMPY-04935	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in mem...
TMPY-04343	PD-L1 Protein, Human, Recombinant (His) PD-L1 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-04343	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been ...