Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.
カタログ番号 | 製品名 / Synonyms | Species | Expression System |
---|---|---|---|
TMPY-06906 | OX40/TNFRSF4 Protein, Human, Recombinant (His & Avi), Biotinylated
OX40/TNFRSF4 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex... | |||
TMPY-06880 | CD86 Protein, Human, Recombinant (His & Avi), Biotinylated
CD86 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan... | |||
TMPY-06875 | OX40/TNFRSF4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
OX40/TNFRSF4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
|
Human | HEK293 |
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex... | |||
TMPY-06831 | 4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc)
4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc)
|
Mouse | HEK293 |
4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfam... | |||
TMPY-06813 | ICOS ligand Protein, Human, Recombinant
ICOS ligand Protein, Human, Recombinant
|
Human | HEK293 |
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb... | |||
TMPY-06794 | 4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (aa 1-187, His & Avi), Biotinylated
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (aa 1-187, His & Avi), Biotinylated
|
Mouse | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... | |||
TMPY-06791 | CD200 Protein, Human, Recombinant (His & Avi), Biotinylated
CD200 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expre... | |||
TMPY-06790 | CD70 Protein, Mouse, Recombinant (His)
CD70 Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept... | |||
TMPY-06770 | CD70 Protein, Mouse, Recombinant (His & Avi), Biotinylated
CD70 Protein, Mouse, Recombinant (His & Avi), Biotinylated
|
Mouse | HEK293 |
CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept... | |||
TMPY-06711 | B7-1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
B7-1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
|
Mouse | HEK293 |
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ... | |||
TMPY-06687 | CD40 Ligand Protein, Mouse, Recombinant (His)
CD40 Ligand Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPY-06622 | CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (His & Avi), Biotinylated
CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (His & Avi), Biotinylated
|
Human,Cynomolgus,Rhesus | HEK293 |
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ... | |||
TMPY-06581 | B7-H3 Protein, Human, Recombinant (isoform 2, His)
B7-H3 Protein, Human, Recombinant (isoform 2, His)
|
Human | HEK293 |
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor... | |||
TMPY-06528 | 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (soluble CD137, His)
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (soluble CD137, His)
|
Human | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... | |||
TMPY-06382 | 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His & Avi), Biotinylated
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... | |||
TMPY-06374 | CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (mFc)
CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (mFc)
|
Human,Cynomolgus,Rhesus | HEK293 |
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ... | |||
TMPY-06363 | B7-H6 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
B7-H6 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
|
Cynomolgus | HEK293 |
B7-H6 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 with His and AVI tag. The predicted molecular weight is 29.76 kDa. Access... | |||
TMPY-06329 | 4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (aa 1-211, His&AVI), Biotinylated
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (aa 1-211, His&AVI), Biotinylated
|
Mouse | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... | |||
TMPY-06299 | CD48 Protein, Human, Recombinant (hFc & Avi), Biotinylated
CD48 Protein, Human, Recombinant (hFc & Avi), Biotinylated
|
Human | HEK293 |
Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami... | |||
TMPY-06298 | B7-1 Protein, Human, Recombinant (His & Avi), Biotinylated
B7-1 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ... |