Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.
カタログ番号 | 製品名 / Synonyms | Species | Expression System |
---|---|---|---|
TMPY-04858 | ICOS ligand Protein, Cynomolgus, Recombinant (hFc)
ICOS ligand Protein, Cynomolgus, Recombinant (hFc)
|
Cynomolgus | HEK293 |
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb... | |||
TMPY-04857 | ICOS ligand Protein, Rat, Recombinant (hFc)
ICOS ligand Protein, Rat, Recombinant (hFc)
|
Rat | HEK293 |
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb... | |||
TMPY-04723 | OX40/TNFRSF4 Protein, Rhesus, Recombinant (His)
OX40/TNFRSF4 Protein, Rhesus, Recombinant (His)
|
Rhesus | HEK293 |
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex... | |||
TMPY-04720 | 4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Rhesus, Recombinant (His)
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Rhesus, Recombinant (His)
|
Cynomolgus,Rhesus | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... | |||
TMPY-04719 | 4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Rhesus, Recombinant (hFc)
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Rhesus, Recombinant (hFc)
|
Cynomolgus,Rhesus | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... | |||
TMPY-04718 | OX40/TNFRSF4 Protein, Rhesus, Recombinant (hFc)
OX40/TNFRSF4 Protein, Rhesus, Recombinant (hFc)
|
Rhesus | HEK293 |
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex... | |||
TMPY-04619 | B7-H6 Protein, Human, Recombinant (His)
B7-H6 Protein, Human, Recombinant (His)
|
Human | HEK293 |
B7-H6 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 28.1 kDa. Accession number: Q68D85 | |||
TMPY-04618 | B7-H6 Protein, Cynomolgus, Recombinant (His)
B7-H6 Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 |
B7-H6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 27.9 kDa. Accession number: XP_005578557.1 | |||
TMPY-04617 | B7-H6 Protein, Cynomolgus, Recombinant (hFc)
B7-H6 Protein, Cynomolgus, Recombinant (hFc)
|
Cynomolgus | HEK293 |
B7-H6 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 53.2 kDa. Accession number: XP_005578557.1 | |||
TMPY-04585 | B7-H3 Protein, Cynomolgus, Recombinant (His)
B7-H3 Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 |
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor... | |||
TMPY-04497 | CD70 Protein, Mouse, Recombinant (mFc)
CD70 Protein, Mouse, Recombinant (mFc)
|
Mouse | HEK293 |
CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept... | |||
TMPY-04495 | B7-H6 Protein, Rat, Recombinant (His)
B7-H6 Protein, Rat, Recombinant (His)
|
Rat | HEK293 |
B7-H6 Protein, Rat, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 35.1 kDa. Accession number: XP_006223356.1 | |||
TMPY-04354 | OX40L/TNFSF4 Protein, Human, Recombinant (mFc)
OX40L/TNFSF4 Protein, Human, Recombinant (mFc)
|
Human | HEK293 |
OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecul... | |||
TMPY-04350 | ICOS ligand Protein, Mouse, Recombinant (His)
ICOS ligand Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb... | |||
TMPY-04349 | B7-1 Protein, Cynomolgus, Rhesus, Recombinant (His)
B7-1 Protein, Cynomolgus, Rhesus, Recombinant (His)
|
Cynomolgus,Rhesus | HEK293 |
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ... | |||
TMPY-04284 | B7-H3 Protein, Rat, Recombinant (His)
B7-H3 Protein, Rat, Recombinant (His)
|
Rat | HEK293 |
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor... | |||
TMPY-04279 | B7-H3 Protein, Mouse, Recombinant (His), Biotinylated
B7-H3 Protein, Mouse, Recombinant (His), Biotinylated
|
Mouse | HEK293 |
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor... | |||
TMPY-04252 | CD28 Protein, Rat, Recombinant (His)
CD28 Protein, Rat, Recombinant (His)
|
Rat | HEK293 |
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ... | |||
TMPY-04208 | CD48 Protein, Mouse, Recombinant (hFc)
CD48 Protein, Mouse, Recombinant (hFc)
|
Mouse | HEK293 |
Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami... | |||
TMPY-04089 | CD40 Protein, Canine, Recombinant (His)
CD40 Protein, Canine, Recombinant (His)
|
Canine | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r... |