Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.
カタログ番号 | 製品名 / Synonyms | Species | Expression System |
---|---|---|---|
TMPJ-00616 | CD27/TNFRSF7 Protein, Rhesus macaque, Recombinant (His)
CD27/TNFRSF7 Protein, Rhesus macaque, Recombinant (His)
|
Rhesus macaque | Human Cells |
CD27 antigen, also known as CD27L receptor, T-cell activation antigen CD27, T14, S152, Tp55, TNFRSF7 and Tumor necrosis factor receptor for superfamily member 7,... | |||
TMPJ-00615 | CD27/TNFRSF7 Protein, Rhesus macaque, Recombinant (hFc)
CD27/TNFRSF7 Protein, Rhesus macaque, Recombinant (hFc)
|
Rhesus macaque | Human Cells |
CD27 antigen, also known as CD27L receptor, T-cell activation antigen CD27, T14, S152, Tp55, TNFRSF7 and Tumor necrosis factor receptor for superfamily member 7,... | |||
TMPJ-00556 | B7-2 Protein, Human, Recombinant (His)
B7-2 Protein, Human, Recombinant (His)
|
Human | Human Cells |
The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or C... | |||
TMPJ-00555 | B7-2 Protein, Human, Recombinant (Avi & His), Biotinylated
B7-2 Protein, Human, Recombinant (Avi & His), Biotinylated
|
Human | Human Cells |
The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or C... | |||
TMPJ-00422 | OX40/TNFRSF4 Protein, Mouse, Recombinant (His)
OX40/TNFRSF4 Protein, Mouse, Recombinant (His)
|
Mouse | Human Cells |
OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis o... | |||
TMPJ-00421 | CD27/TNFRSF7 Protein, Human, Recombinant (hFc & His)
CD27/TNFRSF7 Protein, Human, Recombinant (hFc & His)
|
Human | Human Cells |
CD27 antigen is also known as CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor superfamily member 7, T14 and TNFRSF7. In humans, it... | |||
TMPJ-00353 | ILDR2 Protein, Human, Recombinant (His)
ILDR2 Protein, Human, Recombinant (His)
|
Human | Human Cells |
ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasi... | |||
TMPJ-00219 | BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated
BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | Human Cells |
Butyrophilin subfamily 3 member A2, also known as BT3.2, BTF3, BTF4 and BTN3A2, is a single-pass type I membrane protein. It is a member of the butyrophilin (BTN... | |||
TMPJ-00153 | CD40 Ligand Protein, Human, Recombinant (His & Flag)
CD40 Ligand Protein, Human, Recombinant (His & Flag)
|
Human | Human Cells |
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i... | |||
TMPJ-00152 | CD40 Ligand Protein, Human, Recombinant (His & Avi), Biotinylated
CD40 Ligand Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | Human Cells |
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i... | |||
TMPJ-00151 | CD40 Ligand Protein, Human, Recombinant
CD40 Ligand Protein, Human, Recombinant
|
Human | E. coli |
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i... | |||
TMPJ-00150 | CD40 Ligand Protein, Human, Recombinant (Mammalian)
CD40 Ligand Protein, Human, Recombinant (Mammalian)
|
Human | Human Cells |
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i... | |||
TMPJ-00145 | 4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (hFc)
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (hFc)
|
Mouse | Human Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte acti... | |||
TMPJ-00144 | 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & His)
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & His)
|
Human | Human Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas... | |||
TMPJ-00143 | 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (aa 24-186, His & Avi), Biotinylated
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (aa 24-186, His & Avi), Biotinylated
|
Human | Human Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas... | |||
TMPJ-00142 | 4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Recombinant (His)
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | Human Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necros... | |||
TMPJ-00141 | 4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Recombinant (hFc)
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Recombinant (hFc)
|
Cynomolgus | Human Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necros... | |||
TMPJ-00140 | 4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
4-1BB/CD137/TNFRSF9 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
|
Cynomolgus | Human Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas... | |||
TMPJ-00138 | 4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (His & Flag)
4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (His & Flag)
|
Human | Human Cells |
Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1B... | |||
TMPJ-00130 | SLAMF2 Protein, Human, Recombinant (hFc & His)
SLAMF2 Protein, Human, Recombinant (hFc & His)
|
Human | Human Cells |
CD48 antigen, also known as B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, TCT.1, CD48, BCM1,and BLAST1, CD48 contains ... |