Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.
カタログ番号 | 製品名 / Synonyms | Species | Expression System |
---|---|---|---|
TMPK-00133 | GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His)
GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His)
|
Human | HEK293 Cells |
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune re... | |||
TMPK-00132 | GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His & Avi), Biotinylated
GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His & Avi), Biotinylated
|
Human | HEK293 Cells |
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune re... | |||
TMPK-00111 | CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi), Biotinylated
CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi), Biotinylated
|
Human,Cynomolgus,Rhesus | HEK293 Cells |
CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen present... | |||
TMPK-00110 | CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi)
CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi)
|
Human,Cynomolgus,Rhesus | HEK293 Cells |
CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen present... | |||
TMPK-00087 | ICOS Protein, Human, Recombinant (C136S & C137S, His)
ICOS Protein, Human, Recombinant (C136S & C137S, His)
|
Human | HEK293 Cells |
Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of ... | |||
TMPK-00086 | ICOS Protein, Human, Recombinant (aa 21-134, His)
ICOS Protein, Human, Recombinant (aa 21-134, His)
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Human | HEK293 Cells |
Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of ... | |||
TMPK-00080 | CD27 Ligand/CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
CD27 Ligand/CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
|
Human | HEK293 Cells |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a... | |||
TMPK-00079 | CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His)
CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His)
|
Human | HEK293 Cells |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a... | |||
TMPK-00078 | CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His), FITC-Labeled
CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His), FITC-Labeled
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Human | HEK293 Cells |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a... | |||
TMPK-00063 | OX40L/TNFSF4 Trimer Protein, Human, Recombinant (His & Flag)
OX40L/TNFSF4 Trimer Protein, Human, Recombinant (His & Flag)
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Human | HEK293 Cells |
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L),which belongs to the tumor necrosis factor fam... | |||
TMPJ-01458 | OX40/TNFRSF4 Protein, Cynomolgus, Recombinant (His)
OX40/TNFRSF4 Protein, Cynomolgus, Recombinant (His)
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Cynomolgus | HEK293 Cells |
OX40/TNFRSF4 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-50 KDa and the ... | |||
TMPJ-01441 | OX40L/TNFSF4 Protein, Cynomolgus, Recombinant (His)
OX40L/TNFSF4 Protein, Cynomolgus, Recombinant (His)
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Cynomolgus | HEK293 Cells |
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed by DCs, macrophages and B cells and... | |||
TMPJ-01420 | CD40 Protein, Cynomolgus, Recombinant (hFc)
CD40 Protein, Cynomolgus, Recombinant (hFc)
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Cynomolgus | HEK293 Cells |
CD40 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 48-70 KDa and the accession n... | |||
TMPJ-00959 | B7-2 Protein, Rabbit, Recombinant (His)
B7-2 Protein, Rabbit, Recombinant (His)
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Rabbit | HEK293 Cells |
B7-2 Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-70 KDa and the accession nu... | |||
TMPJ-00958 | B7-1 Protein, Rabbit, Recombinant (His)
B7-1 Protein, Rabbit, Recombinant (His)
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Rabbit | HEK293 Cells |
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of ... | |||
TMPJ-00920 | CD40 Ligand Protein, Mouse, Recombinant (aa 112-260, His)
CD40 Ligand Protein, Mouse, Recombinant (aa 112-260, His)
|
Mouse | HEK293 Cells |
CD40 Ligand, also known as TNFSF5, CD154, is a type II transmembrane glycoprotein member of the TNF superfamily. Mature mouse CD40 Ligand consists of a 22 amino ... | |||
TMPJ-00641 | B7-2 Protein, Rhesus macaque, Recombinant (His)
B7-2 Protein, Rhesus macaque, Recombinant (His)
|
Rhesus | HEK293 Cells |
B7-2 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 40-90 KDa and the acce... | |||
TMPJ-00634 | CD40 Protein, Cynomolgus, Recombinant (His)
CD40 Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 Cells |
CD40 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-30 KDa and the accessio... | |||
TMPJ-00632 | B7-2 Protein, Cynomolgus, Recombinant (hFc)
B7-2 Protein, Cynomolgus, Recombinant (hFc)
|
Cynomolgus | HEK293 Cells |
B7-2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 70-100 KDa and the accession ... | |||
TMPJ-00630 | B7-1 Protein, Cynomolgus, Recombinant (hFc)
B7-1 Protein, Cynomolgus, Recombinant (hFc)
|
Cynomolgus | HEK293 Cells |
Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-pr... |