Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.
カタログ番号 | 製品名 / Synonyms | Species | Expression System |
---|---|---|---|
TMPY-02031 | B7-H3 Protein, Human, Recombinant (His)
B7-H3 Protein, Human, Recombinant (His)
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Human | HEK293 |
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor... | |||
TMPY-04064 | B7-H3 Protein, Mouse, Recombinant (His)
B7-H3 Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor... | |||
TMPY-01612 | CD155/PVR Protein, Rhesus, Recombinant (His)
CD155/PVR Protein, Rhesus, Recombinant (His)
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Rhesus | HEK293 |
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne... | |||
TMPY-01180 | CD86 Protein, Human, Recombinant (His)
CD86 Protein, Human, Recombinant (His)
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Human | HEK293 |
CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan... | |||
TMPY-03203 | CD40 Protein, Rat, Recombinant (His)
CD40 Protein, Rat, Recombinant (His)
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Rat | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r... | |||
TMPY-02022 | CD40 Ligand Protein, Human, Recombinant (hFc)
CD40 Ligand Protein, Human, Recombinant (hFc)
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Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPY-01743 | 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His)
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (His)
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Human | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... | |||
TMPY-01423 | OX40/TNFRSF4 Protein, Human, Recombinant (His)
OX40/TNFRSF4 Protein, Human, Recombinant (His)
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Human | HEK293 |
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex... | |||
TMPY-06021 | CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (His)
CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (His)
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Human,Cynomolgus,Rhesus | HEK293 |
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ... | |||
TMPY-03401 | CD27/TNFRSF7 Protein, Human, Recombinant (His)
CD27/TNFRSF7 Protein, Human, Recombinant (His)
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Human | Baculovirus-Insect Cells |
CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on t... | |||
TMPY-05376 | 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc)
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc)
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Human | HEK293 |
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro... | |||
TMPY-01181 | CD40 Protein, Human, Recombinant (His)
CD40 Protein, Human, Recombinant (His)
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Human | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r... | |||
TMPY-05354 | CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated
CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated
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Human | HEK293 |
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ... | |||
TMPY-01152 | DNAM-1/CD226 Protein, Human, Recombinant (His)
DNAM-1/CD226 Protein, Human, Recombinant (His)
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Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPY-01386 | CD155/PVR Protein, Human, Recombinant (His)
CD155/PVR Protein, Human, Recombinant (His)
|
Human | HEK293 |
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne... | |||
TMPY-00699 | CD155/PVR Protein, Human, Recombinant (hFc)
CD155/PVR Protein, Human, Recombinant (hFc)
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Human | HEK293 |
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne... | |||
TMPY-01672 | ICOS ligand Protein, Human, Recombinant (His)
ICOS ligand Protein, Human, Recombinant (His)
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Human | HEK293 |
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb... | |||
TMPY-06979 | ICOS Protein, Human, Recombinant (His)
ICOS Protein, Human, Recombinant (His)
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Human | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa... | |||
TMPY-06953 | CD70 Protein, Human, Recombinant (His)
CD70 Protein, Human, Recombinant (His)
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Human | HEK293 |
CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept... | |||
TMPY-06909 | B7-1 Protein, Rat, Recombinant (His)
B7-1 Protein, Rat, Recombinant (His)
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Rat | HEK293 |
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ... |