Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.
カタログ番号 | 製品名 / Synonyms | Species | Expression System |
---|---|---|---|
TMPK-00463 | OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi)
OX40/TNFRSF4 Protein, Mouse, Recombinant (His & Avi)
|
Mouse | HEK293 |
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molec... | |||
TMPK-00315 | B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ... | |||
TMPK-00314 | B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
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Human | HEK293 |
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ... | |||
TMPK-00280 | B7-H6 Protein, Human, Recombinant (His & Avi), Biotinylated
B7-H6 Protein, Human, Recombinant (His & Avi), Biotinylated
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Human | HEK293 |
B7-H6 is a glycosylated member of the B7 family of immune co‑stimulatory proteins. which is a ligand for the NK cell activating receptor NKp30, was targeted to c... | |||
TMPK-00260 | CD155/PVR Protein, Human, Recombinant (His & Avi)
CD155/PVR Protein, Human, Recombinant (His & Avi)
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Human | HEK293 |
CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tum... | |||
TMPK-00237 | 2B4/CD244 Protein, Human, Recombinant (aa 22-221, His & Avi), Biotinylated
2B4/CD244 Protein, Human, Recombinant (aa 22-221, His & Avi), Biotinylated
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Human | HEK293 |
2B4 (CD244) is expressed by memory-phenotype CD8() T cells and all natural killer (NK) cells. The ligand for 2B4, CD48, is expressed on hematopoietic cells. 2B4 ... | |||
TMPK-00230 | DNAM-1/CD226 Protein, Human, Recombinant (His & Avi), Biotinylated
DNAM-1/CD226 Protein, Human, Recombinant (His & Avi), Biotinylated
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Human | HEK293 |
DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular... | |||
TMPK-00229 | DNAM-1/CD226 Protein, Human, Recombinant (His & Avi)
DNAM-1/CD226 Protein, Human, Recombinant (His & Avi)
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Human | HEK293 |
DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular... | |||
TMPK-00224 | BTN3A2 Protein, Human, Recombinant (His & Avi)
BTN3A2 Protein, Human, Recombinant (His & Avi)
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Human | HEK293 |
BTN3A2/BT3.2 butyrophilin mRNA expression by tumoral cells was previously identified as a prognostic factor in a small cohort of high grade serous epithelial ova... | |||
TMPK-00192 | B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi)
B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi)
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Human | HEK293 |
B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulat... | |||
TMPK-00179 | B7-1 Protein, Human, Recombinant (aa 35-242, His & Avi), Biotinylated
B7-1 Protein, Human, Recombinant (aa 35-242, His & Avi), Biotinylated
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Human | HEK293 |
Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal ne... | |||
TMPK-00178 | B7-1 Protein, Human, Recombinant (His & Avi)
B7-1 Protein, Human, Recombinant (His & Avi)
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Human | HEK293 |
Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal ne... | |||
TMPK-00170 | CD40 Protein, Human, Recombinant (aa 21-193, His & Avi), Biotinylated
CD40 Protein, Human, Recombinant (aa 21-193, His & Avi), Biotinylated
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Human | HEK293 |
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activate... | |||
TMPK-00169 | OX40/TNFRSF4 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
OX40/TNFRSF4 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
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Human | HEK293 |
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molec... | |||
TMPK-00168 | OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated
OX40/TNFRSF4 Protein, Human, Recombinant (aa 29-216, His & Avi), Biotinylated
|
Human | HEK293 |
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molec... | |||
TMPK-00167 | OX40/TNFRSF4 Protein, Human, Recombinant (His & Avi)
OX40/TNFRSF4 Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 |
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molec... | |||
TMPK-00154 | CD40 Ligand Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated
CD40 Ligand Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated
|
Human | HEK293 |
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It b... | |||
TMPK-00152 | CD27/TNFRSF7 Protein, Cynomolgus, Recombinant (His)
CD27/TNFRSF7 Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 |
CD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a co‑stimulatory molecule that sup... | |||
TMPK-00148 | 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (aa 24-186, hFc & Avi), Biotinylated
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (aa 24-186, hFc & Avi), Biotinylated
|
Human | HEK293 |
4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but ... | |||
TMPK-00147 | 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & Avi)
4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (hFc & Avi)
|
Human | HEK293 |
4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but ... |