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TQ0311 |
GSK163090
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3). |
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T4560 |
Alprenolol
|
Alpheprol,(RS)-Alprenolol,dl-Alprenolol |
5-HT Receptor
,
Adrenergic Receptor
|
|
Alprenolol (Alpheprol) is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B. |
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T8593 |
RU 24969
|
5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole |
5-HT Receptor
|
|
RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole) is a selective agonist of 5-HT1A and 5-HT1B receptors. |
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T22236 |
Alprenolol hydrochloride
|
|
5-HT Receptor
|
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Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor. |
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T0203 |
Sumatriptan succinate
|
GR 43175 |
5-HT Receptor
|
|
Sumatriptan succinate (GR 43175), a serotonin1 (5-HT1) receptor agonist, is used in the acute treatment of a migraine headache. |
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T8737 |
GR 125743
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|
5-HT Receptor
|
|
GR 125743 is a novel antagonist of 5-HT1B/1D receptor. |
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T11326 |
Frovatriptan succinate hydrate
|
Frovelan,Frova |
5-HT Receptor
|
|
Frovatriptan succinate hydrate (Frova) is effective in treating the full spectrum of migraine including the associated symptoms of nausea, vomiting, photophobia, and phonophobia. Frovatriptan succinate hydrate can also b... |
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T11075 |
Donitriptan
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|
5-HT Receptor
|
|
Donitriptan is a 5-HT receptor agonist with pKis of 9.4 and 9.3 for 5-HT1B and 5-HT1D, respectively. |
|
T7498 |
Eltoprazine hydrochloride
|
DU 28853 hydrochloride |
5-HT Receptor
|
|
Eltoprazine hydrochloride (DU 28853 hydrochloride) is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively). |
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T12861 |
SB-277011
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SB-277011A |
Dopamine Receptor
|
|
SB-277011 (SB-277011A) is a specific antagonist of the dopamine D3 receptor with pKi values of 8.0, 6.0, 5.0, and <5.2 for D3 receptor, D2 receptor, 5-HT1D, and 5-HT1B respectively. |
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T22808 |
GR 46611
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5-HT Receptor
|
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GR 46611 is a selective 5-HT1B and 5-HT1D receptor agonist and can be used in studies about the treatment of epilepsy. |
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T12841 |
SB-224289 hydrochloride
|
SB-224289A |
5-HT Receptor
|
|
SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect. |
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T12847 |
SB-616234-A
|
SB-616234A |
5-HT Receptor
|
|
SB-616234A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity. |
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T15414 |
GR 113808
|
GR-113808 |
5-HT Receptor
|
|
GR 113808 is a selective 5-HT4 receptor antagonist that inhibits 5-HT1B, 5-HT2A, 5-HT2C, and 5-HT3 receptors and attenuates morphine-stimulated dopamine release in the rat striatum.CAS 번호12483-87-86-1 |
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T22689 |
CP94253 hydrochloride
|
CP 94253 hydrochloride |
Others
,
5-HT Receptor
|
|
CP94253 hydrochloride (CP 94253 hydrochloride) is a potent, selective and centrally active agonist of 5-HT1B receptor with Ki of 2 nM. The Kis are 89, 49, 860, and 1600 nM for 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors, ... |
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T6423 |
BRL-15572 dihydrochloride
|
BRL 15573 dihydrochloride |
5-HT Receptor
|
|
BRL-15572 dihydrochloride (BRL 15573 dihydrochloride) is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B recepto... |
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T0216 |
Eletriptan hydrobromide
|
Eletriptan HBr,UK-116044 |
5-HT Receptor
|
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Eletriptan hydrobromide (Eletriptan HBr) is an orally active agonist with specific affinity for the 5-hydroxytriptamine1B/1D receptor. |
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T2317 |
Almotriptan Malate
|
LAS 31416,PNU180638 |
5-HT Receptor
|
|
Almotriptan Malate (PNU180638), a selective 5-HT1B/1D receptor agonist, is used in the therapy of Migraine attacks in adults. |
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T21666 |
Donitriptan hydrochloride
|
Donitriptan HCl,Donitriptan monohydrochloride |
5-HT Receptor
|
|
Donitriptan hydrochloride (Donitriptan monohydrochloride) is a potent, high efficacy agonist of 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively |
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T22576 |
Anpirtoline hydrochloride
|
D-16949 hydrochloride |
5-HT Receptor
|
|
Anpirtoline hydrochloride (D-16949 hydrochloride) is a novel and potent 5-HT1B receptor agonist and 5-HT3 receptor antagonist with anti-injurious, analgesic, and antidepressant activity, and is used in the study of movem... |
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T50039 |
3-(2-aminopropyl)phenol hydrochloride
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Others
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3-(2-aminopropyl)phenol hydrochloride is a phenethylamine analog used as a molecular structural unit. It is a psychoactive drug that is a partial agonist at several serotonin receptors, including 5-HT1A, 5-HT1B, and 5-HT... |
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T1092 |
Zolmitriptan
|
311C90,BW-311C90 |
5-HT Receptor
|
|
Zolmitriptan (311C90) selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and... |
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T2395 |
Vortioxetine
|
Lu AA 21004 |
5-HT Receptor
,
Serotonin Transporter
|
|
Vortioxetine (Lu AA 21004) is a serotonergic antidepressant used for major depression disorders. Vortioxetine has been associated with a low rate of minor serum aminotransferase elevations during treatment. |
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T21231 |
Almotriptan
|
LAS 31416 |
5-HT Receptor
|
|
Almotriptan (LAS 31416) is a 5-HT1B/1D-receptor agonist used to treat migraine.Almotriptan is a triptan drug for treatment of migraine headaches.Binding of the drug to the receptor leads to vasoconstriction of the crania... |
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T4118 |
SB 271046 hydrochloride
|
SB 271046A |
5-HT Receptor
|
|
SB 271046 hydrochloride (SB 271046A) is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and ... |
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T2395L |
Vortioxetine hydrobromide
|
Vortioxetine (Lu AA21004) HBr,Vortioxetine HBr,Lu AA21004 hydrobromide |
5-HT Receptor
,
Serotonin Transporter
|
|
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM). |
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T6602 |
Naratriptan hydrochloride
|
Naratriptan HCl,Amerge,Naramig,GR-85548A hydrochloride |
5-HT Receptor
|
|
Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydroc... |
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T4305 |
8-OH-Dpat
|
8-Hydroxy-DPAT |
5-HT Receptor
|
|
8-OH-Dpat (8-Hydroxy-DPAT) is a serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. |
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T22653 |
CGS 12066B dimaleate
|
|
Others
|
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5-HT1B full agonist |
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T36949 |
Niaprazine
|
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5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research[1][2].
Niaprazine exhibits a low aff... |
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T23055 |
NAS181
|
NAS-181 |
Others
|
|
rat 5-HT1B receptor antagonist |
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T22872 |
Isamoltane hemifumarate
|
|
Others
|
|
5-HT1B antagonist |
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T23405 |
Sumatriptan
|
|
Others
|
|
Sumatriptan succinate is a selective 5-HT1 receptor agonist with specificity towards 5-HT1D, 5-HT1B, and 5-HT1A. |
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T14190 |
Alniditan
|
Alnitidan |
5-HT Receptor
|
|
Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively. |
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T10360 |
AR-A 2
|
AR-A 000002 |
Others
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|
AR-A 2 is a selective 5-HT1B receptor antagonist, with a high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D... |
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T22524 |
5-Nonyloxytryptamine oxalate
|
|
Others
|
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5-HT1B agonist |
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T22809 |
GR 55562 dihydrochloride
|
|
Others
|
|
5-HT1B (5-HT1Dβ) silent antagonist |
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T12861L |
SB-277011 dihydrochloride
|
SB-277011A dihydrochloride |
Dopamine Receptor
|
|
SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively). |
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T22953 |
LY 393558
|
|
Others
|
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Dual 5-HT1B/1D receptor antagonist |
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T22688 |
CP 93129 dihydrochloride
|
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Others
|
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5-HT1B agonist, potent and highly selective |
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T10380 |
AS19
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|
5-HT Receptor
|
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AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis: 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). |
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T27432 |
GR-55562 dihydrobromide
|
GR 55562 dihydrobromide |
|
|
GR-55562 dihydrobromide is a antagonist of 5-HT1B/5-HT1D serotonin receptor. |
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T22806 |
GR 127935 hydrochloride
|
|
Others
|
|
5-HT1B/1D receptor antagonist |
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T36063 |
N-desmethyl Zolmitriptan
|
|
|
|
N-desmethyl Zolmitriptan (DZT) is an active metabolite of the serotonin (5-HT) receptor subtype 5-HT1B and 5-HT1D agonist zolmitriptan . DZT is an agonist of 5-HT1B receptors that induces contraction of isolated human ce... |
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T71103 |
AZD3676
|
|
|
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AZD3676 is a novel dual antagonist of serotonin 5-HT1A and 5-HT1B receptor. |
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T27196 |
Donitriptan Mesylate
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Donitriptan mesilate,F12640,F-12640,F 12640 |
|
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Donitriptan Mesylate, a 5-HT1B/1D agonist, is used potentially for the treatment of migraines. |
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T70559 |
GR-127935
|
|
|
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GR-127935 is a potent and selective 5-HT1B/1D receptor antagonist. |
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T28678 |
SB 649915
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SB-649915,SB649915 |
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SB 649915 is a serotonin reuptake inhibitor and 5-HT1A and 5-HT1B receptor antagonist. |
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T27000 |
CGS-12066 maleate salt
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CGS12066,CGS-12066,CGS -12066 |
|
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CGS-12066 maleate salt is an agonist of 5-HT1B serotonin receptor. |
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T28677 |
SB 272183
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SB-272183,SB272183 |
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SB 272183 is a highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drug. |
