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Search Results for " ALR "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T2013	Ponalrestat		Reductase
	Ponalrestat is an aldose reductase inhibitor.		Reductase
T14303	Alrizomadlin	APG-115,AA-115	Mdm2
	Alrizomadlin (APG-115) is an orally active inhibitor of MDM2 with IC50 of 3.8 nM and Ki of 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-d...		Mdm2
T77523	ALR2-IN-1		Reductase
	ALR2-IN-1 is a potent and selective ALR2 inhibitor with an IC50 value of 1.42 μM.ALR2-IN-1 possesses both antiglycemic and antioxidant activities and can be used to study the complications of diabetes.		Reductase
T33389	Minalrestat	ARI509,WAY-121509,WAY121509,WAYARI-509,ARI-509,WAY-ARI-509	Reductase
	Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.		Reductase
T7604	Valrubicin	Valstar,AD-32	Antibiotic , PKC
	Valrubicin (AD-32) (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.		Antibiotic , PKC
T3562	Valrocemide	TV1901,N-Valproylglycinamide	Others
	Valrocemide (TV1901), also known as TV-1901, is an antiepileptic drug (AED). Valrocemide has a broad spectrum of anticonvulsant activity and promising potential as a new AED. Valrocemide is an anticonvulsant agent under ...		Others
T1458	Epalrestat	ONO2235	Reductase
	Epalrestat (ONO2235), an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particul...		Reductase
T1832	Walrycin B		Antibacterial , Antibiotic
	Walrycin B is a new-type antibacterial compound targeting the WalR response regulator.		Antibacterial , Antibiotic
T5195	Alrestatin	AY-22284	Reductase
	Alrestatin (AY-22284) is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.		Reductase
T76252L	WLSEAGPVVTVRALRGTGSW TFA
	WLSEAGPVVTVRALRGTGSW TFA, a cardiomyocyte-specific peptide, exhibits enhanced performance through its expression in exosomes, which notably improves uptake by cardiomyocytes, reduces apoptosis within these cells, and inc...
T70610	ALRN-6924
	ALRN-6924 is a novel dual MDM4 and MDM2 inhibitor.
T62456	ALR1/2-IN-1
	ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) (IC50: 3.26 μM) and aldose reductase (ALR2) (IC50: 3.06 μM) inhibitor with anticancer effects.
T5195L	Alrestatin Sodium	AY 22284A,AY-22284A,Alrestatine sodium,AY22284A
	Alrestatin is a specific inhibitor of the aldose reductase enzyme.
T83135	Alrefimotide	hTERT (660–689)
	Alrefimotide, an immunogenic peptide derived from hTERT, possesses the sequence ALFSVLNYERARRPGLLGASVLGLDDIHRA and has applications in cancer immunotherapy research [1].
T73305	ALR2-IN-3
	ALR2-IN-2, a potent aldose reductase (ALR2) inhibitor, demonstrates IC50 values of 22 nM for rat ALR2 and 116 nM for ALR1, respectively. This compound is utilized in diabetic complications research.
T26601	ALRT 1550	LG-1550,LGD-1550,ALRT-1550,LG1550,ALRT-550,ALRT1550
	ALRT 1550, a retinoic acid agent (RAR) agonist, is used potentially for the treatment of cervical carcinoma.
T73304	ALR2-IN-2
	ALR2-IN-2, a potent aldose reductase (ALR2) inhibitor, exhibits IC50 values of 27 nM for rat ALR2 and 228 nM for ALR1, respectively. This compound is utilized in the research of diabetic complications.
T60186	(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide		Discoidin Domain Receptor (DDR)
	MitoBloCK-6 is an effective inhibitor of Erv1/ALR with IC50 values of 900 nM and 700 nM, respectively. Additionally, MitoBloCK-6 inhibits Erv2 (IC50=1.4 μM). It induces apoptosis in hESCs by promoting the release of cyto...		Discoidin Domain Receptor (DDR)
T3572	NSC 15364	1,3-Bis(4-aminophenyl)urea,NSC15364	Apoptosis , Others , VDAC
	NSC 15364 (1,3-Bis(4-aminophenyl)urea) can be used for screening of ALR inhibitors by detection of hydrogen peroxide production Measured in Biochemical System.		Apoptosis , Others , VDAC
T60143	MitoBloCK-6		Apoptosis
	MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC 50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 with IC 50 of 1.4 μM. MitoBloCK-6 can induce apoptosis via cytochrome c release in human embryo...		Apoptosis

Compounds

Synonym: APG-115,AA-115

Synonym: ARI509,WAY-121509,WAY121509,WAYARI-509,ARI-509,WAY-ARI-509

Target: Reductase

Valrubicin

T7604

Synonym: Valstar,AD-32

Target: Antibiotic, PKC

Valrocemide

T3562

Synonym: TV1901,N-Valproylglycinamide

Target: Antibacterial, Antibiotic

WLSEAGPVVTVRALRGTGSW TFA

Synonym: AY 22284A,AY-22284A,Alrestatine sodium,AY22284A

Target:

Alrefimotide

T83135

Synonym: hTERT (660–689)

Synonym: LG-1550,LGD-1550,ALRT-1550,LG1550,ALRT-550,ALRT1550

(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide

T60186

Synonym:

Target: Discoidin Domain Receptor (DDR)

NSC 15364

T3572

Synonym: 1,3-Bis(4-aminophenyl)urea,NSC15364

Target: Apoptosis, Others, VDAC

カタログ番号	製品名	ターゲット
TN5140	Thalrugosidine	Others
	Thalrugosidine is a natural product from Thalictrum foliolosum DC.	Others
TN2271	Thalrugosaminine	Antifection
	Thalrugosaminine shows promising antibacterial activity with MIC values of 64-128ug/ml and Staphylococcus species is the most sensitive strains. Thalrugosaminine possesses hypotensive activity in rabbits and is active ag...	Antifection

天然物製品

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00368	ALR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Alterations in GFER gene have been associated with progressive mitochondrial myopathy, congenital cataracts, hearing loss, developmental delay, lactic acidosis and respiratory chain deficiency in 3 siblings born to consa...
TMPJ-01020	GFER Protein, Human, Recombinant (His)	Human	E. coli
	GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isofo...
TMPY-02461	AKR1A1 Protein, Human, Recombinant (His)	Human	E. coli
	Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehy...
TMPY-02438	AKR1B1 Protein, Human, Recombinant (His)	Human	E. coli
	Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest...
TMPH-00436	Calreticulin Protein, Cricetulus griseus, Recombinant (His)	Chinese hamster	P. pastoris (Yeast)
	Calreticulin Protein, Cricetulus griseus, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 48.1 kDa and the accession number is Q8K3H7.
TMPY-03258	Calreticulin Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Calreticulin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73 kDa and the accession number is P27797.
TMPH-03105	Calreticulin Protein, Pig, Recombinant (His)	Sus scrofa (Pig)	P. pastoris (Yeast)
	Calreticulin Protein, Pig, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 48.6 kDa and the accession number is P28491.
TMPH-03065	Alr2278 Protein, Nostoc sp., Recombinant (His & MBP)	Nostoc	Baculovirus Insect Cells
	Alr2278 Protein, Nostoc sp., Recombinant (His & MBP) is expressed in Baculovirus.
TMPY-06327	Calreticulin Protein, Human, Recombinant	Human	HEK293 Cells
	Calreticulin Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.99 kDa and the accession number is P27797.
TMPH-02559	Calreticulin Protein, Mouse, Recombinant (GST)	Mouse	E. coli
	Calreticulin Protein, Mouse, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 73.3 kDa and the accession number is P14211.
TMPH-02558	Calreticulin Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Calreticulin Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 48.3 kDa and the accession number is P14211.
TMPY-03259	Calreticulin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Calreticulin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.4 kDa and the accession number is P27797.