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TP1724L |
PUMA BH3 acetate
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PUMA BH3 acetate(PUMA BH3 Free base) |
BCL
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PUMA BH3 acetate (PUMA BH3 Free base) is a p53 positive regulator of apoptosis (PUMA) BH3 domain polypeptide that acts as a direct activator of Bak with a Kd of 26 nM. |
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T40379 |
Bax BH3 peptide (55-74), wild type
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Bax BH3 peptide (55-74), wild type |
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Bax BH3 peptide (55-74), wild type is a 20-amino acid peptide (Bax 1) known for its ability to induce apoptosis in various cell line models. |
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TP1836 |
BMf-BH3
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BMf-BH3 belongs to the Bcl-2 apoptosis mediator family. This peptide belongs to the Bcl-2 apoptosis mediator family. Bmf is a key player in histone deacetylase (HDAC) inhibition, which alters the balance between deacetyl... |
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TP1724 |
PUMA BH3
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PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM.This is a PUMA BH3 domain peptide. PUMA proteins bind Bcl-2, localize to the mitochond... |
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TP1808 |
Bak BH3
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This peptide, generated from the BH3 domain of Bak (Flu-BakBH3), has been shown to have high-affinity binding to a surface pocket of the Bcl-XL protein that is required for its death antagonist function. |
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TP1712 |
PUMA BH3 (TFA)
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PUMA BH3 (TFA) is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM. |
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TP1718 |
Bim BH3, Peptide IV TFA (721885-31-0 free base)
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Bim BH3, Peptide IV TFA |
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Bim BH3, Peptide IV TFA is a 26-site residue of BH3 protein Bim, belonging to the pro-apoptotic group of bcl-2 protein family. |
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TP1611 |
Bim BH3, Peptide IV
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This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins. |
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T80231 |
Bik BH3
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Bik BH3, a biologically active peptide derived from the BH3 domain of BIK, exhibits specific functions pertinent to its origin. |
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T80038 |
Bim BH3
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Bim BH3 is a bioactive peptide that belongs to the pro-apoptotic Bcl-2 family of proteins. |
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T80232 |
Hrk BH3
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Hrk BH3, a biologically active peptide comprising the BH3 domain of Hrk, exhibits functionality within cellular processes. |
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T76073 |
BH3 hydrochloride
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BH3 hydrochloride, a peptide that crosses the blood-brain barrier, induces apoptosis either through direct activation of the pro-apoptotic proteins Bax/Bak or by inhibiting anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, B... |
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T80227 |
Noxa A BH3
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Noxa A BH3, a bioactive peptide, encompasses the BH3 domain of the Noxa protein. |
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T75980 |
PUMA BH3 TFA
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PUMA BH3 (TFA), a peptide from the BH3 domain of the p53 upregulated modulator of apoptosis (PUMA), directly activates Bak with a dissociation constant (Kd) of 26 nM [1]. |
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T80223 |
Bad BH3 (mouse)
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Bad BH3 (mouse) is a bioactive peptide derived from the BH3 domain (a death domain) of Bad, encompassing amino acid residues 140 to 165, and functions by binding to bcl-2. |
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T80226 |
R8 Bid BH3
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r8 Bid BH3, a biologically active peptide, is a pro-apoptotic member of the "BH3-only" subset within the BCL-2 family proteins, pivotal in regulating apoptosis. This compound exhibits lethality towards Bcl-2-expressing h... |
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T80229 |
Noxa B BH3
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Noxa B BH3, a biologically active peptide encompassing the BH3 domain of the Noxa protein, displays targeted biological activity. |
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T83114 |
Angiopep-Bim BH3 hydrochloride
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Angiopep-Bim BH3 hydrochloride, a peptode that penetrates the blood-brain barrier (BBB), may serve as a tool to study the permeability of central nervous system (CNS) therapeutics [1]. |
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T80224 |
Bid BH3 (80-99)
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Bid BH3 (80-99) is a biologically active peptide known as a pro-apoptotic member of the 'BH3-only' (BOPS) subset within the BCL-2 protein family, pivotal in apoptosis regulation. It notably interacts with Bcl-2, Bax, and... |
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T83751 |
PUMA BH3 (human) TFA
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PUMA BH3, a peptide that includes the BH3 domain from the p53-upregulated modulator of apoptosis (PUMA) and activates the pro-apoptotic protein Bak, demonstrates binding affinity to Bak with dissociation constants (Kds) ... |
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T76030 |
Bim BH3, Peptide IV TFA
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Bim BH3, Peptide IV TFA, is a 26-residue peptide derived from the BH3-only protein Bim, a member of the pro-apoptotic Bcl-2 protein family [1] [2]. |
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T80228 |
R8-Gly-Noxa A BH3
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r8-Gly-Noxa A BH3 is a biologically active peptide with cell-permeability, comprising amino acid residues 17 to 36 derived from the BH3 (death) domain of Noxa A. The peptide is modified by the addition of eight D-Arginin... |
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T80029 |
Bak BH3 (72-87), TAMRA-labeled
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Bak BH3 (72-87), TAMRA-labeled, is a bioactive peptide. |
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T80225 |
Bid BH3 (80-99), FAM labeled
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FAM-labeled Bid BH3 (80-99) is a biologically active peptide featuring a 5-FAM label at its N-terminus. |
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T2099 |
ABT-737
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Mitophagy
,
BCL
,
Autophagy
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ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM). |
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T16156 |
MT 63-78
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Apoptosis
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AMPK
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mTOR
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MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63–78 also causes cel... |
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T6275 |
Obatoclax Mesylate
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Obatoclax,GX15-070 |
BCL
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Parasite
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Autophagy
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Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3. |
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T1493 |
BH3I-1
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BHI1 |
BCL
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E1/E2/E3 Enzyme
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BH3I-1 (BHI1) is a Bcl-2 antagonist. |
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T26789 |
BH3I-2'
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BH3I2',BH3I 2' |
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BH3I-2' is a cell-permeable BH3 mimetic. BH3I-2' induces apoptosis by specifically preventing BH3 domain-mediated interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family, thereby blocking the in... |
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T76543 |
NoxaBH3
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NoxaBH3, a cysteine-based cross-linked peptide, exhibits enhanced cell permeability and greater inhibitory efficacy against Mcl-1. It binds to the endogenous CXCR4 ligand, resulting in the formation of a ubiquitin-NoxaBH... |
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T31821 |
Fluorizoline
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Apoptosis
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Fluorizoline is a PHB-binding compound with anticancer and antiproliferative activity that induces apoptosis by inducing selective targeting of the BH3 protein NOXA to PHB.Fluorizoline inhibits protein synthesis and has ... |
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T77571 |
Bcl-B inhibitor 1
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Apoptosis
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BCL
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Bcl-B inhibitor 1 is a Bcl-B inhibitor with antitumor activity that binds to and inactivates pro-apoptotic proteins in the BH3 structural domain. |
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T14376 |
AZD4320
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BCL
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AZD4320 is an inhibitor of BH3-mimicking dual BCL2/BCLxL. For KPUM-MS3, KPUM-UH1, and STR-428 cells, the IC50s values are 26 nM, 17 nM, and 170 nM , respectively. |
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T40412L |
BAD (103-127) (human) acetate
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BAD (103-127) (human) acetate (331762-68-6 Free base) |
Others
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BAD (103-127) (human) acetate is a 25-mer Bad polypeptide from the BAD BH3 domain that antagonizes the effects of Bcl-xl. |
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T6034 |
UMI-77
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UMI77,UMI 77 |
BCL
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UMI-77, a specific Mcl-1 inhibitor (Ki: 490 nM), has selectivity over other members of Bcl-2 family. |
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T5827 |
BI-6C9
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Apoptosis
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Others
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Mitochondrial Metabolism
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BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death. |
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T69218 |
PUMAi HCl
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PUMAi is an inhibitor of p53 up-regulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family member, mitigating acetaminophen (APAP)-induced hepatocyte necrosis and liver injury. |
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T32344 |
JY-1-106
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JY-1 106,JY-1106 |
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JY-1-106 is a BH3 α-helix mimetic, inducing apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak. |
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T68653 |
YC-137
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YC-137 is a BCL-2 inhibitor, which selectively induces apoptosis of Bcl-2-overexpressing cells and disrupts its interaction with Bid BH3, thereby blocking the anti-apoptotic activity of Bcl-2. |
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T76082 |
BAD (103-127) (human), FAM-labeled
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BAD (103-127) (human), FAM-labeled, is a FAM-labeled 25-mer peptide derived from the BH3 domain of human BAD. This peptide can antagonize the function of Bcl-xL [1]. |
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T40412 |
BAD (103-127) (human)
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BAD (103-127) (human) is a 25-mer peptide obtained from the BH3 domain of BAD. It effectively counteracts the activity of Bcl-xL. Notably, BAD (103-127) (human) exhibits an approximately 800-fold greater binding affinity... |
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T41278 |
Obatoclax
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Obatoclax (GX15-070), a pan-BCL-2 family proteins inhibitor and BH3 mimetic, exhibits a binding affinity (K_i) of 220 nM for BCL-2. It promotes autophagy-dependent cell death and cyclin D1 degradation via the proteasome.... |
