|
T6058 |
LY2886721
|
|
Beta-Secretase
,
BACE
|
|
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease. |
|
T8719 |
SC99
|
|
Apoptosis
,
JAK
,
STAT
|
|
SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activiti... |
|
T23602 |
ABC99
|
ABC 99,ABC-99 |
Wnt/beta-catenin
|
|
ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family. |
|
T12071 |
MKC9989
|
|
IRE1
|
|
MKC9989 is an inhibitor of Hydroxy aryl aldehydes (HAA). MKC9989 also inhibits IRE1α with an IC50 of 0.23 to 44 μM. |
|
T29065 |
UNC9994
|
UNC-9994,UNC 9994 |
|
|
UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities. |
|
T29064 |
UNC9975
|
UNC-9975 |
|
|
UNC9975 is an analog of aripiprazole and a β-arrestin-biased D2R agonist. |
|
T62853 |
UNC9994 hydrochloride
|
|
|
|
UNC9994 hydrochloride is a functionally selective, β-arrestin-biased dopamine D2 receptor (D2R) agonist (Ki: 79 nM) that selectively activates β- arresttin recruitment and signal transduction. UNC9994 hydrochloride is a ... |
|
T29066 |
UNC9995
|
UNC-9995,UNC 9995 |
|
|
UNC9995 is a β-Arrestin-Biased Dopamine D2 Receptor agonist (β-Arrestin, EC50 = 120 nM; Emax = 88%). |
|
T116837 |
TLC9995-0188
|
|
|
|
Tyrosine-protein kinase ABL, IC50: 1500 nM |
|
T6870 |
L-685458
|
L-685,458 |
Apoptosis
,
Gamma-secretase
|
|
L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. |
