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T27033 |
CKD-712
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CKD 712,CKD712 |
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CKD-712 is a nuclear factor NF-kappa B inhibitor. CKD-712 suppressed MMP-9, but not MMP-2 and other NF-κB-regulated proteins involved in cancer metastasis such as VEGF. CKD-712 induced cell cycle arrest at G2M phase by s... |
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T7551 |
Belotecan hydrochloride
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CKD-602 |
Topoisomerase
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Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity |
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T13278 |
Valecobulin hydrochloride
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CKD-516 hydrochloride |
Microtubule Associated
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T27841 |
Lobeglitazone Sulfate
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CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang |
NOD
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Lobeglitazone Sulfate（CKD-501 Sulfate） is a novel thiazolidinedione with anti-inflammatory activity that inhibits LPS-induced NLRP3 inflammasome activation and hepatic inflammation, and can be used in the study of type 2... |
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T36700 |
CKD 602
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Topoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian ... |
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T14976 |
CKD-519
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Others
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CKD-519 is a selective inhibitor of cholesteryl ester transfer protein (CETP). It inhibits CETP-mediated transfer of cholesteryl ester in human serum (IC50: 2.3 nM). |
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T13278L |
Valecobulin
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CKD-516 |
Others
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Valecobulin is a potent β-tubulin polymerization inhibitor. Valecobulin is a valine prodrug of (S516) and an avascular disrupting compound. |
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T28945 |
Tenofovir disoproxil aspartate
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CKD-390,CKD390,CKD 390 |
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Tenofovir disoproxil aspartate, a nucleotide reverse transcriptase inhibitor, is used potentially for the treatment of HBV infection. |
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T19871 |
Beloranib
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CKD-732,ZGN 440 |
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Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor. |
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T8494 |
NS-3-008 hydrochloride
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NS-3-008 HCl |
Others
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NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM). |
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T69011 |
Lobeglitazone
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Lobeglitazone, also known as CKD-501, is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat ce... |
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T16708 |
R-268712
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ALK
,
TGF-beta/Smad
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R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor. |
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T71845 |
Lockdown
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Lockdown is a reversible and non-competitive PPM1F inhibitor. Lockdown is selective for PPM1F, because this compound does not inhibit other protein phosphatases in vitro and does not induce additional phenotypes in PPM1F... |
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T30479 |
Bis-T-23
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Bis T-23,Bis-T 23,AG1717 |
HIV Protease
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Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV... |
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T13604 |
CDDO-dhTFEA
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|
Others
,
NF-κB
,
Nrf2
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CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expressi... |
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T12823 |
S516
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|
Microtubule Associated
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S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity. |
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T39410 |
Zevaquenabant
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(S)-MRI-1867 |
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Zevaquenabant ((S)-MRI-1867), a dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist, is orally bioavailable and peripherally restricted. It effectively mitigates obesity-induced chronic kidney disease (CKD)... |
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T69294 |
UK‑396082
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UK-396082 is a potent inhibitor of thrombin-activated fibrinolytic inhibitor (TAFI), enhancing plasmin activity while concurrently reducing levels of the extracellular matrix (ECM). This compound is valuable for research... |
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T62435 |
Belotecan
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Belotecan (CKD-602 free base) is an inhibitor of DNA topoisomerase I. Belotecan blocks the cell cycle and induces apoptosis and is an antitumour derivative of camptothecin that can be used in cancer research. |
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T76947 |
Ziltivekimab
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|
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Ziltivekimab (COR-001), a human anti-IL-6 monoclonal antibody, efficiently lowers serum CRP levels and exhibits anti-inflammatory properties. It is potentially useful in researching chronic systemic inflammation and card... |
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T78513 |
Sodium zirconium cyclosilicate
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Others
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Sodium zirconium cyclosilicate, an orally administered, non-absorbed, microporous zirconium silicate, acts as a highly selective cation exchanger to remove excess potassium (K+) in vivo. It has potential use in the resea... |
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T73332 |
BI-685509
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BI-685509 is a potent and orally active sGC activator. BI-685509 restores cyclic guanosine monophosphate (cGMP) and improves functionality of nitric oxide (NO) pathways. BI-685509 can be used in research of chronic kidne... |
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T62589 |
TRPC5-IN-4
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TRPC5-IN-4, a potent and safe TRPC inhibitor, exhibits IC50 values of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively, indicating high efficacy. It does not cause damage to liver and kidney cellular components, maki... |
