|
T5402 |
DDR1-IN-2
|
DDR1 inhibitor 7rh |
Discoidin Domain Receptor (DDR)
|
|
DDR1-IN-2 (DDR1 inhibitor 7rh) (DDR1 inhibitor 7rh) is a potent, selective, ATP-competitive Discoidin domain receptor 1 (DDR1) inhibitor (IC50: 6.8 nM in cell-free kinase assays). |
|
T3337 |
Ddr1-In-1
|
|
Discoidin Domain Receptor (DDR)
|
|
DDR1-IN-1 is an effective and specific DDR1 receptor tyrosine kinase inhibitor (IC50: 105 nM), about 3-fold selectivity over DDR2. |
|
T40061 |
DDR1-IN-6
|
DDR1-IN-6 |
|
|
DDR1-IN-6 is a potent and selective inhibitor of Discoidin Domain Receptor family member 1 (DDR1), exhibiting remarkable inhibitory activity at an IC50 of 9.72 nM. It effectively suppresses the auto-phosphorylation of DD... |
|
T40062 |
DDR1-IN-5
|
DDR1-IN-5 |
|
|
DDR1-IN-5 is a potent and selective inhibitor of the Discoidin Domain Receptor family, member 1 (DDR1). It effectively inhibits the phosphorylation of DDR1b (Y513) with an IC 50 value of 4.1 nM. Furthermore, DDR1-IN-5 de... |
|
T39572 |
DDR1-IN-4
|
DDR1-IN-4 |
|
|
DDR1-IN-4 (Compound 2.45) is a highly potent inhibitor that selectively targets Discoidin Domain Receptor 1 (DDR1) autophosphorylation. This compound demonstrates exceptional efficacy with IC50 values of 29 nM and 1.9 μM... |
|
T70202 |
DDR1-IN-1 dihydrochloride
|
|
|
|
DDR1-IN-1 dihydrochloride is a selective and potent inhibitor of the DDR1 receptor tyrosine kinase, exhibiting an IC50 of 105 nM. It demonstrates fourfold reduced potency against DDR2, with an IC50 of 413 nM. |
|
T79811 |
DDR1/2 inhibitor-2
|
|
|
|
DDR1/2 Inhibitor-2 (Example 31) serves as an inhibitor of DDR1/DDR2, exhibiting IC50 values below 100 nM. It is applicable in cancer and fibrotic disease research [1]. |
|
T70201 |
S 16020-2
|
|
|
|
S 16020-2 is an olivacine derivative, and DNA topoisomerase II inhibitor endowed with a remarkable antitumor activity against various experimental tumors. |
|
T4646 |
TA-02
|
|
p38 MAPK
,
Autophagy
|
|
TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2. |
|
T4349 |
Sitravatinib
|
MG516,MGCD516 |
Discoidin Domain Receptor (DDR)
,
VEGFR
,
FLT
,
Trk receptor
,
TAM Receptor
,
c-Kit
,
Ephrin Receptor
|
|
Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl. |
|
T10984 |
DDR-TRK-1
|
|
Discoidin Domain Receptor (DDR)
|
|
DDR-TRK-1 is a selective discoid domain receptor 1 (DDR1) inhibitor with IC50 value of 9.4 nM. DDR-TRK-1 also inhibits the TRK family. |
|
T10985 |
DDR Inhibitor
|
|
Discoidin Domain Receptor (DDR)
|
|
DDR inhibitor is a potent discidin domain receptor (DDR) inhibitor. The IC50 of DDR2 is 3.3 nM, and DDR1 has 53% inhibition at 1.5 nM. |
|
T7862 |
VU6015929
|
|
Discoidin Domain Receptor (DDR)
|
|
VU6015929 is an inhibitor of active dual discoidin domain receptor 1/2 (DDR1/2)( IC50s of 4.67 nM and 7.39 nM, respectively). |
|
T60805 |
JNK3 inhibitor-2
|
|
|
|
JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor. The IC50 values of JNK3 inhibitor-2 for JNK1, JNK2, JNK3 are >100, >100, 0.25 μM, respectively. JNK3 inhibitor-2 also inhibits DDR1 and EGFR (T790M, L858R) [1]. |
|
T12925 |
Sitravatinib malate
|
MGCD516 malate,MG-516 malate |
TAM Receptor
|
|
Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT... |
|
T15808 |
Merestinib dihydrochloride
|
LY2801653 dihydrochloride |
ROCK
|
|
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK... |
|
T10801 |
CHMFL-ABL/KIT-155
|
CHMFL-ABL-KIT-155 |
c-Kit
|
|
CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis. |
