|
T10096L |
Voruciclib
|
|
CDK
|
|
Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the ... |
|
T16040 |
Mepazine
|
Pecazine |
Apoptosis
,
MALT
|
|
Mepazine (Pecazine) is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability. |
|
T3549 |
Avadomide
|
CC 122 |
Apoptosis
,
E1/E2/E3 Enzyme
,
Ligand for E3 Ligase
|
|
Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity. |
|
T14367 |
AZ1495
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|
IRAK
,
CDK
,
Haspin Kinase
|
|
AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffu... |
|
T5354 |
IRAK4-IN-7
|
CA-4948 |
IRAK
|
|
IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model. |
|
T2558 |
Cladribine
|
2-chlorodeoxyadenosine,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA |
Apoptosis
,
Adenosine deaminase
|
|
Cladribine (2CdA), an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases. |
|
T77367 |
Urelumab
|
BMS-663513,BMS-66513 |
Others
|
|
Urelumab(BMS-66513) is a humanized IgG4 monoclonal antibody, often used as a CD137 agonist.Urelumab has potential antitumor activity, potentiating tumor cell killing by T-cells and natural killer cells, and enhancing the... |
|
T78875 |
BTM-3528
|
|
Mitochondrial Metabolism
|
|
BTM-3528 is a mitochondrial protease OMA1 activator that induces an overactivation of the mitochondrial integrated stress response (ISR). It promotes OMA1-dependent cleavage of DELE1 and OPA1, leading to mitochondrial fr... |
|
T79485 |
IRAK4-IN-27
|
|
IRAK
|
|
IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) c... |
|
T61767 |
IRAK4-IN-17
|
|
|
|
IRAK4-IN-17 (Compound 5) is a highly potent inhibitor of IRAK4, exhibiting an impressive IC50 value of 1.3 nM [1]. This compound is particularly valuable for research focused on large B-cell lymphoma (DLBCL) [1]. |
|
T73869 |
BCL6 PROTAC 1
|
|
|
|
BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) proteolysis targeting chimera (PROTAC) that inhibits the BCL6 cell reporter with an IC50 value of 8.8 µM and significantly degrades BCL6 in diffuse large B-cell lymph... |
|
T38096 |
MLT-231
|
|
|
|
MLT-231, a potent and highly selective allosteric MALT1 inhibitor, has an IC50 of 9 nM and specifically inhibits endogenous BCL10 cleavage with an IC50 of 160 nM. It exhibits antitumor activity in an ABC-DLBCL type xenog... |
|
T27615 |
INUB
|
|
|
|
iNUB is a NEMO-Ub binding inhibitor. iNUB inhibits TNFα induced NF-κB signaling and has selectively toxic to IKK/NF-κB dependent ABC-DLBCL. |
|
T77940 |
Tazemetostat de(methyl morpholine)-COOH
|
|
Ligands for Target Protein for PROTAC
|
|
Tazemetostat de(methyl morpholine)-COOH (compound 7), a PROTAC ligand for EZH2, facilitates the synthesis of PROTACs that target this enzyme. These EZH2 degraders exhibit potent inhibition of cell viability in diffuse la... |
|
T26688 |
Avadomide HCl
|
Avadomide hydrochloride,CC122, Avadomide HCl,CC-122,CC 122 HCl |
|
|
Avadomide is an orally available pleiotropic pathway modulator with potential antineoplastic activity. CC-122 mimics an interferon response and has antitumor activity in DLBCL CC-122 binds Cereblon (CRBN) and promotes de... |
|
T77713 |
BTM-3566
|
BTM 3566,BTM3566 |
Apoptosis
|
|
BTM-3566 activates the ISR through the mitochondrial protease OMA1.BTM-3566 induces apoptosis in cancer cells. BTM-3566 overactivates the mitochondrial ISR to study DLBCL. |
|
T62680 |
(R)-MLT-985
|
|
|
|
(R)-MLT-985 (compound 11) is a potent inhibitor of MALT1 protease (IC50: 3 nM). (R)-MLT-985 has an IC50 value of 20 nM for MALT1-dependent IL-2 in Jurkat cells.(R)-MLT-985 inhibits growth and aberrant CARD11/BCL10/MALT1 ... |
|
T81696 |
NBI-961
|
|
|
|
NBI-961, a potent NEK2 inhibitor, suppresses proteasomal degradation and effectively induces G2/mitosis arrest and apoptosis within diffuse large B cell lymphoma (DLBCL) cells [1]. |
|
T82994 |
Anzurstobart
|
BMS-986351,CC-95251 |
|
|
Anzurstobart (CC-95251; BMS-986351), a fully human monoclonal anti-SIRPα antibody with high affinity, inhibits CD47-SIRPα interaction. It potentiates macrophage-mediated phagocytosis of DLBCL cell lines in co-culture ass... |
|
T77070 |
Loncastuximab
|
|
|
|
Loncastuximab (RB4v1.2), an anti-CD19 monoclonal antibody, exhibits antitumor properties and holds potential for treating non-Hodgkin's lymphoma (NHL), specifically diffuse large B-cell lymphoma (DLBCL) [1] [2]. |
|
T74664 |
KTX-582
|
|
PROTACs
|
|
KTX-582 is a potent IRAK4 degrader, exhibiting DC50 values of 4 nM for IRAK4 and 5 nM for Ikaros. It efficiently induces apoptosis in MYD88 MT DLBCL and has demonstrated effectiveness in inducing in vivo tumor regression... |
|
T84316 |
ARV-393
|
|
PROTACs
|
|
ARV-393 is a BCL6 PROTAC degrader with DC50 and GI50 values of <1 nM in both DLBCL and BL cell lines. ARV-393 inhibits tumor volume in multiple tumor xenograft models. |
|
T62403 |
DM-01
|
|
|
|
DM-01 is a potent and selective inhibitor of EZH2. DM-01 can be used to study diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and SNF5/INI-1/SMARCB1 gene-associated solid tumours. |
|
T61153 |
Mepazine hydrochloride
|
|
|
|
Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective inhibitor of the MALT1 protease, with IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 325-760. It enhances apoptosis and ... |
|
T63262 |
IRAK4-IN-15
|
|
|
|
IRAK4-IN-15 is a selective and potent IRAK4 inhibitor (IC50: 0.002 μM) with good human PK prediction and low intrinsic clearance.IRAK4-IN-15 in combination with Acalabrutinib exhibited potent synergistic in vitro activit... |
|
T79801 |
TCIP 1
|
|
Epigenetic Reader Domain
|
|
TCIP 1 is a small molecule in the category of transcriptional/epigenetic covalent inhibitor probes (TCIPs) that forms covalent bonds with molecules targeting BCL6 and BRD4. This compound facilitates cell death gene expre... |
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T63278 |
IRAK4-IN-14
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|
|
|
IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect. |
