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T38961 |
DP-1
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DP-1, a Ganetespib degradation product, represents a fragment derived from SDC-TRAP-0063. Ganetespib itself functions as an inhibitor of heat shock protein 90 (HSP90), exhibiting notable anti-tumor properties. |
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T38961L |
DP-1 hydrochloride
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DP-1 hydrochloride(1472616-61-7 Free base) |
Drug Metabolite
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DP-1 hydrochloride is a degradation product of SDC-TRAP-0063, a fragment of Ganetespib, a heat shock protein 90 (HSP90) inhibitor with antitumor activity. |
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T4297 |
Flibanserin
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BIMT-17BS,Girosa,BIMT-17 |
Dopamine Receptor
,
5-HT Receptor
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Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n... |
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T78033 |
SDP116
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SDP116, a synthetic peptide derivative of the GPR116 Stachel sequence, exhibits ADGRF5 agonistic activity [1]. |
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T76219 |
MDP1
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MDP1, derived from Melittin, disrupts the membrane integrity of both Gram-positive and Gram-negative bacteria, leading to bacterial death through membrane damage. This compound exhibits potent antibacterial activity agai... |
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T76219L |
MDP1 acetate
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MDP1 acetate, a derivative of Melittin, compromises the membrane integrity of both Gram-positive and Gram-negative bacteria leading to bacterial death through membrane damage. It exhibits potent antibacterial activity ag... |
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T62965 |
TDP1 Inhibitor-2
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TDP1 Inhibitor-2 is a potent inhibitor of TDP1 (tyrosyl-DNA phosphodiesterase 1) (IC50: 99 nM) and inhibits SCAN1 (spinal cerebellar ataxia syndrome with axonal neuropathy) (IC50: 3.5 μM). |
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T13109 |
TDP1 Inhibitor-1
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Others
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TDP1 Inhibitor-1 is a potent inhibitor of Tyrosyl-DNA Phosphodiesterase 1 (TDP1) (IC50 of 7 μM). |
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T5386 |
Asapiprant
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Prostaglandin Receptor
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Asapiprant (S-555739) is a potent and selective DP1 receptor antagonist (Ki: 0.44 nM). It exhibited high affinity and selectivity for the DP1 receptor. |
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T5150 |
Treprostinil
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LRX-15,Orenitram,Remodulin |
Prostaglandin Receptor
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Treprostinil (Orenitram) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM). |
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T14842 |
BW 245C
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BW245C |
Prostaglandin Receptor
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BW 245C is a selective prostaglandin-like DP receptor (DP1) agonist, a prostaglandin analogue with inhibitory effects on the aggregation response of collagen, which can be used to study diseases such as stroke. |
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T15712 |
Laropiprant
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MK-0524 |
Prostaglandin Receptor
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Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM). |
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T4635 |
Ralinepag
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APD811 |
Others
,
Prostaglandin Receptor
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Ralinepag (APD811) is a potent, orally bioavailable agonist of non-prostanoid prostacyclin (IP) receptor, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively. |
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T5171 |
Treprostinil Sodium
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UT-15 |
VEGFR
,
c-RET
,
Prostaglandin Receptor
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Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM). |
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T63349 |
Treprostinil diethanolamine
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UT-15C |
Prostaglandin Receptor
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Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FPKi, respectively. Treprostinil diethanolamine i... |
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T5482 |
TG4-155
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Prostaglandin Receptor
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TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channels |
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T7359 |
CAY10471 Racemate
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TM30089 Racemate |
GPR
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Prostaglandin Receptor
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CAY10471 Racemate (TM30089 Racemate) is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 Racemate binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and >10,000 nM,respectivel... |
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T6399 |
AZD1981
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GPR
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Prostaglandin Receptor
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AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. AZD1981 has been used in trials studying th... |
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T3306 |
PF-04418948
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PF 04418948,PF04418948 |
Prostaglandin Receptor
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PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a divers... |
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T15829 |
L 888607 Racemate
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Aurora Kinase
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L 888607 Racemate is a selective antagonist of prostaglandin D2 receptor subtype 1 (DP1) (Kis: 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively). |
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T28651 |
S-5751
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S 5751 |
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S-5751, a prostanoid DP (DP1) antagonist, is used potentially for the treatment of bronchial asthma. |
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T69967 |
Laropiprant analog
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Laropiprant analog is an antagonist of the prostaglandin PGD2 receptor DP1. |
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T39165 |
Treprostinil palmitil
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Treprostinil palmitil,INS-1009 |
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Treprostinil Palmitil (TP), a prodrug of the DP1 and EP2 agonist Treprostinil (UT-15), exhibits EC50 values of 0.6 and 6.2 nM, respectively. It is a pure prodrug without any inherent binding affinity for G-protein couple... |
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T4981 |
Anisotropine Methylbromide
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Prostaglandin Receptor
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AChR
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Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion. |
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T36545 |
Prostaglandin D2 methyl ester
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Prostaglandin D2 methyl ester |
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Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypoten... |
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T38365 |
CAY10597
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The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and... |
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T10891 |
CRTH2-IN-1
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Ramatroban analog |
P450
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CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay. |
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T15828 |
L 888607
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Others
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L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM). |
