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Search Results for " FOXO1 "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	ターゲット
T78187	FOXO1-IN-3	Others
	FOXO1-IN-3 is a highly-selective, orally active inhibitor of FOXO1 that diminishes hepatic glucose production and enhances insulin sensitivity and glucose regulation in db/db mice, all without inducing weight gain [1].	Others
T9243	PFI-90	Histone Demethylase , Others
	PFI-90, a selective histone demethylase (KDM3B) inhibitor, targets PAX3-FOXO1 action and demonstrates potential antitumor activity. It induces apoptosis and myogenic differentiation, leading to increased cell death.	Histone Demethylase , Others
T6762	AS1842856	Autophagy , FOXO1
	AS1842856, a cell-permeable inhibitor, can block the transcription activity of Foxo1 (IC50: 33 nM). It can directly bind to the active Foxo1, but not the Ser256-phosphorylated form.	Autophagy , FOXO1
T73578	JY-2	FOXO1
	JY-2 is an orally active and selective forkhead transcription factor O1 (FoxO1) inhibitor with antidiabetic activity and inhibits FoxO1 transcription.JY-2 can be used to study psoriasis and diabetes.	FOXO1
T16077	MIR96-IN-1	MALT
	MIR96-IN-1 selectively inhibits biogenesis of microRNA-96, upregulating a protein target (FOXO1) and inducing apoptosis in cancer cells.	MALT
T26661	AS1708727
	AS1708727 is a Foxo1 inhibitor, exerting anti-hypertriglyceridemic and anti-diabetic effects by improving triglyceride and blood glucose metabolism at the gene expression level.
T76648	Acetyl-Exenatide
	Acetyl-Exenatide, an acetylated derivative of Exenatide, mirrors insulin's functionality and is utilized in type 2 diabetes research. It promotes Th17 differentiation, inhibits Tregs differentiation, and downregulates PI...

Compounds

Target: Histone Demethylase, Others

AS1842856

T6762

Synonym:

Target: Autophagy, FOXO1

カタログ番号	製品名	別名	ターゲット
T3773	Oxypaeoniflorin	Oxypaeoniflora	Others
	Oxypaeoniflorin (Oxypaeoniflora) is a natural product derived from Radix Paeoniae Rubra and Radix Paeoniae Alba.		Others
TN1911	Marein		transporter , Akt , HDAC , AMPK
	Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for ...		transporter , Akt , HDAC , AMPK
TN4390	Kihadanin B		Akt , PPAR , FOXO1
	Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.		Akt , PPAR , FOXO1
T27564	Hymenidin		5-HT Receptor
	Hymenidin, an alkaloid isolated from the Okinawan sponge Hymeniacidon sp. is a 5-hydroxytryptaminergic receptor antagonist and voltage-gated potassium channel inhibitor with potential antiprotozoal effects.It selectively...		5-HT Receptor

天然物製品

Oxypaeoniflorin

T3773

Synonym: Oxypaeoniflora

Target: transporter, Akt, HDAC, AMPK

Kihadanin B

TN4390

Synonym:

Target: Akt, PPAR, FOXO1

Hymenidin

T27564

Synonym:

Target: 5-HT Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPK-01034	SEMA4B Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling p...
TMPK-00368	MMP-9 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demon...
TMPK-00367	MMP-9 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demon...
TMPK-00503	MMP-9 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demon...
TMPH-02131	SKP2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle pr...
TMPH-01556	EIF2AK2 Protein, Human, Recombinant (His)	Human	Yeast
	IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to v...
TMPH-03274	ATF-4 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, an...