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T8527 |
CPYPP
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Others
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|
CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 µM). CPY... |
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T15485 |
HJC0197
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|
cAMP
,
Ras
|
|
HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2). |
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T15247 |
ESI-05
|
NSC 116966 |
cAMP
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|
ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation. |
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T16369 |
O-Desmethyl gefitinib
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|
EGFR
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O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 acti... |
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T7099 |
Gefarnate
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Others
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Gefarnate is a synthetic compound used for the treatment of gastric ulcers,and also used in the treatment of dry eye syndrome. |
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T5099 |
Gefapixant
|
RO 4926219,AF219,MK-7264 |
P2X Receptor
|
|
Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. |
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T65550 |
Gefitinib analog III
|
4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate |
Others
|
|
Gefitinib analog III (4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate) has potential anti-inflammatory and anti-tumor activity and can be used to study its interactions and activity in organisms. |
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T5437 |
Gefitinib-based PROTAC 3
|
|
EGFR
,
PROTACs
|
|
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectivel... |
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T63846 |
Gefapixant citrate
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|
|
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Gefapixant citrate is an orally active P2X3 receptor (P2X3R) antagonist that acts on human homologous recombinant hP2X3 (IC50: ~30 nM) and hP2X2/3 (IC50: 100-200 nM). gefapixant citrate can be used to study chronic cough... |
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T40785 |
Gefitinib impurity 1
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|
|
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Gefitinib impurity 1 is a compound derived from Gefitinib, a potent and selective EGFR tyrosine kinase inhibitor (IC 50 = 33 nM). This orally active compound selectively inhibits tumor cell growth stimulated by EGF (IC 5... |
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TMIH-0250 |
Gefapixant-d3
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|
|
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Gefapixant-d3 is a deuterated compound of Gefapixant. Gefapixant has a CAS number of 1015787-98-0. Gefapixant is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at h... |
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T19489 |
O-Desmethyl gefitinib D8
|
|
EGFR
|
|
O-Desmethyl gefitinib D8 is a deuterium labeled O-Desmethyl gefitinib that is an active metabolite of Gefitinib in human plasma. |
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T67092 |
Gefitinib impurity 2
|
|
|
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Gefitinib impurity 2 is a useful organic compound for research related to life sciences and the catalog number is T67092. |
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T73627 |
Gefitinib N-oxide hydrochloride
|
|
|
|
Gefitinib N-oxide hydrochloride, an N-oxide derivative of Gefitinib, acts as an EGFR tyrosine kinase inhibitor. Demonstrating an IC50 range of 2-37 nM in NR6wtEGFR cells, it emphasizes its efficacy in inhibiting the enzy... |
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T11385 |
Gefitinib N-oxide
|
|
Others
|
|
Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib. |
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T63630 |
Gefitinib dihydrochloride
|
|
|
|
Gefitinib dihydrochloride is a potent, selective, orally active EGFR tyrosine kinase inhibitor (IC50: 33 nM). Gefitinib dihydrochloride selectively inhibits EGF-stimulated tumor cell growth with an IC50 value of 54 nM an... |
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T1181L |
Gefitinib hydrochloride
|
|
|
|
Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent and orally active EGFR tyrosine kinase inhibitor (EGFR-TKI) (IC 50 = 33 nM) that selectively inhibits EGF-stimulated tumor cell growth (IC 50 = 54 nM) and that b... |
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T81714 |
N3-PEG8-Phe-Lys-PABC-Gefitinib
|
|
|
|
N3-PEG8-Phe-Lys-PABC-Gefitinib is an antibody-drug conjugate (ADC) agent-linker complex exhibiting potent antitumor activity. It incorporates the orally active EGFR tyrosine kinase inhibitor Gefitinib, tethered by the cl... |
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T76375 |
Targefrin
|
|
|
|
Targefrin is a potent antagonist targeting EphA2, exhibiting a dissociation constant of 21 nM and an IC50 value of 10.8 nM for the EphA2-LBD. It promotes receptor internalization and degradation across multiple pancreati... |
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TMIH-0402 |
O-Desmethyl Gefitinib-d8
|
|
|
|
O-Desmethyl Gefitinib-d8 is a deuterated compound of O-Desmethyl Gefitinib. O-Desmethyl Gefitinib has a CAS number of 847949-49-9. O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma,... |
|
T11384 |
Gefitinib-d8
|
ZD1839 D8,Gefitinib D8 |
Others
|
|
Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib. |
|
T77022 |
Gefurulimab
|
|
|
|
Gefurulimab (ALXN-1720) is a bispecific antibody derived from humans, targeting complement C5 and albumin. It specifically binds to C5, inhibiting its activation [1]. |
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T18316 |
MC-Sq-Cit-PAB-Gefitinib
|
|
Others
|
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MC-Sq-Cit-PAB-Gefitinib is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), utilizing Gefitinib—an EGFR tyrosine kinase inhibitor—connected through the MC-Sq-Cit-PAB ADC linker. |
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T77875 |
Mc-Val-Cit-PAB-Gefitinib chloride
|
|
|
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Mc-Val-Cit-PAB-Gefitinib chloride is a conjugate agent-linker for antibody-drug conjugates (ADCs) that combines Gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, with the proprietary ADC li... |
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T65585 |
Gefitinib impurity 5
|
|
|
|
Gefitinib impurity 5 is a useful organic compound for research related to life sciences. The catalog number is T65585 and the CAS number is 199327-61-2. |
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TP2131L |
Rac1 Inhibitor W56 acetate(1095179-01-3 free base)
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|
Rho
|
|
Rac1 Inhibitor W56 acetate(1095179-01-3 free base) is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1. Rac1 Inhibitor W56 acetate(1095179-01-3 free ... |
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T16745 |
Rhosin hydrochloride
|
|
Apoptosis
,
Rho
,
Ras
|
|
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 o... |
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T6342 |
NSC 23766 trihydrochloride
|
Rac1 Inhibitor,NSC 23766 |
Apoptosis
,
Rho
,
Ras
|
|
NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42. |
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T16746 |
Rhosin
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|
Rho
|
|
Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin does not interact with Cdc42 or Rac1, nor the GEF, LARG. R... |
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TP2131 |
Rac1 Inhibitor W56
|
|
|
|
Rac1 Inhibitor W56 is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1. Rac1 Inhibitor W56 selectively inhibits Rac1 interaction with Rac1-specific G... |
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T24554 |
NSC-658497
|
NSC658497 |
|
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NSC-658497 is a SOS1-Ras interaction inhibitor that acts by dose-dependently inhibiting SOS1 GEF activity. |
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T75932 |
Rac1 Inhibitor W56 TFA
|
|
|
|
Rac1 Inhibitor W56 TFA, a peptide comprised of residues 45-60 of Rac1, selectively obstructs Rac1's interaction with the guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam [1]. |
|
TP2130L |
Rac1 Inhibitor F56, control peptide acetate
|
Rac1 Inhibitor F56, control peptide acetate(1315378-77-8 free base) |
Rho
|
|
Rac1 Inhibitor F56, control peptide acetate is a control peptide version of Rac1 Inhibitor; comprises residues 45-60 of Rac1 with Trp56 replaced by Phe. Does not affect GEF-Rac1 interaction. |
|
TP2130 |
Rac1 Inhibitor F56, control peptide
|
|
|
|
Control peptide version of Rac1 Inhibitor; comprises residues 45-60 of Rac1 with Trp56 replaced by Phe. Does not affect GEF-Rac1 interaction. |
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T37422 |
Ras Inhibitory Peptide
|
|
|
|
Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to t... |
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T83813 |
8-Azidoadenosine-5'-O-diphosphate sodium
|
8-azido-ADP,Click Tag™ 8-Azidoadenosine-5'-O-diphosphate |
|
|
8-Azidoadenosine-5'-O-diphosphate (8-azido-ADP), a clickable variant of the ATP precursor and purinergic receptor ligand ADP, serves as a photoaffinity label for proteins including glutamate dehydrogenase (GDH) isoprotei... |
