store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride causes cell apoptosis.
説明 | Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride causes cell apoptosis. |
ターゲット&IC50 | RhoA:(kd)0.4 uM |
In vitro | Rhosin hydrochloride causes decreased size and reduced number of mammospheres in MCF7 cells. Rhosin hydrochloride dose-dependently reduces RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres (EC50: ~30-50 μM) [1]. |
分子量 | 431.318 |
分子式 | C20H20Cl2N6O |
CAS No. | 1281870-42-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (253.25 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Rhosin hydrochloride 1281870-42-5 Apoptosis Cell Cycle/Checkpoint GPCR/G Protein MAPK Rho Ras plasticity D1-MSN MCF7 hyperexcitability stress Rhosin selective inhibit cells Inhibitor resiliency Rhosin Hydrochloride inhibitor