|
T1792L |
Regorafenib monohydrate
|
|
Raf
,
VEGFR
,
c-RET
,
PDGFR
,
c-Kit
,
Autophagy
|
|
Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respect... |
|
T1792 |
Regorafenib
|
BAY 73-4506,Fluoro-Sorafenib |
Raf
,
VEGFR
,
c-RET
,
PDGFR
,
c-Kit
,
Autophagy
|
|
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active. Regorafenib has antitumor and anti-angiogenic activity. |
|
T21312 |
Afatinib
|
Afatinib free base,BIBW 2992 |
EGFR
,
Autophagy
|
|
Afatinib (BIBW 2992) is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM , respectively). |
|
T1773 |
Afatinib Dimaleate
|
BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate |
EGFR
,
HER
,
Autophagy
|
|
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act... |
|
T72310 |
Antibacterial agent 132
|
|
Antifungal
|
|
Antibacterial agent 132 showed antimicrobial activity against C. parapsilosis (ATCC 22019) and C. krusei (ATCC 6258) with MIC90 values of <0.06 μg/mL and 62.50 μg/mL, respectively. Antibacterial agent 132 inhibited aroma... |
|
T36821 |
FQI 1
|
|
|
|
FQI 1 is an SV40 factor (LSF) inhibitor. FQI 1 inhibits cell proliferation, with IC50s of 3, 0.79, and 6.3 μM for NIH/3T3, HeLa, and A549 cells, respectively. FQI1 could be used in cancer research. |
|
T10849 |
CMLD012612
|
|
Others
|
|
|
|
T10848 |
CMLD012073
|
|
Others
|
|
|
|
T36542 |
Prostaglandin A2
|
Medullin |
|
|
PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some anti... |
|
T69618 |
XR3054
|
|
|
|
XR3054 is a novel inhibitor of farnesyl protein transferase (FPTase). XR3054 inhibited the proliferation of the prostatic cancer cell lines LnCAP and PC3 and the colon carcinoma SW480 and HT1080 (IC50 values of 12.4, 12.... |
