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T4661 |
PKG drug G1
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PKA
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PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism. |
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TP1523 |
PKG inhibitor peptide TFA (82801-73-8 free base)
|
PKG inhibitor peptide TFA |
PKA
|
|
PKG inhibitor peptide TFA (82801-73-8 free base) is an inhibitor of ATP-competitive cGMP-dependent protein kinase (PKG). |
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TP1787L |
PKG Substrate acetate（81187-14-6 free base)
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PKA
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PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = ... |
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TP1787 |
PKG Substrate
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|
|
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PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 µM) over PKG II (Km = 305 µM). |
|
TP1903 |
PKG inhibitor peptide
|
cGMP Dependent Kinase Inhibitor Peptide |
|
|
Competitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit pho... |
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T81448 |
PKG inhibitor peptide TFA
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|
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PKG inhibitor peptide TFA is an ATP-competitive antagonist of cGMP-dependent protein kinase (PKG), exhibiting a K_i value of 86 μM [1]. |
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T7648 |
HA-100
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Myosin
,
PKA
,
PKC
|
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HA-100 is an inhibitor of protein kinase |
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T63311 |
PfPKG-IN-1
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|
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PfPKG-IN-1, an imidazole-based inhibitor, targets the Plasmodium falciparum cyclic guanosine monophosphate-dependent protein kinase (PfPKG). |
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T63844 |
PKG1α activator 3
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PKG1α activator 3 is a PKG1α activator (EC50basal/partial=13/0.52 μM). PKG1α activator 3 is able to inhibit the proliferation of smooth muscle cells and can be used to study cardiovascular diseases. |
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T13807 |
OSIP-486823
|
CP248 |
Microtubule Associated
,
PKA
|
|
OSIP-486823（CP248） is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules. |
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T27525 |
HA-1004
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Serine/threonin kinase
,
PKA
,
PKC
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HA-1004 inhibits cGKI, MYLK, PKA, PKC, and calcium channel protein. |
|
T35328 |
H-1152 dihydrochloride
|
H-1152 2HCl,H-1152 dihydrochloride |
ROCK
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H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 ... |
|
T14064 |
8-Bromo-cGMP sodium
|
|
Calcium Channel
,
PKA
|
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8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimula... |
|
T24051 |
Exisulind
|
Sulindac sulfone,CP248 |
Apoptosis
,
PKA
|
|
Exisulind (CP248) induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth i... |
|
T6250 |
H-89 dihydrochloride
|
Protein kinase inhibitor H-89 dihydrochloride,H 89 2HCl,5-Isoquinolinesulfonamide |
PKA
,
S6 Kinase
,
Autophagy
|
|
H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM). |
|
T1606 |
Fasudil
|
HA-1077,AT877 |
ROCK
,
Serine/threonin kinase
,
Calcium Channel
,
PKA
,
PKC
,
Autophagy
|
|
Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK. |
|
T67755 |
Protein kinase G inhibitor-1
|
|
PKA
|
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Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM. |
|
T23252 |
Rp-8-Br-PET-cGMPS
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Others
|
|
cGMP-dependent protein kinase (PKG) inhibitor |
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T82525 |
DT-2
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DT-2 serves as a potent, selective inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 12.5 nM, effectively hindering PKG-catalyzed phosphorylation [1]. |
|
T11524 |
H-89
|
Protein kinase inhibitor H-89 |
Others
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T38842 |
HA-100 hydrochloride
|
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|
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HA-100 hydrochloride is a powerful protein kinase inhibitor, exhibiting IC50 values of 4 μM, 8 μM, 12 μM, and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC), a... |
|
T15670 |
KT5823
|
|
Apoptosis
,
PKA
|
|
KT5823 is a selective and potent cGMP-dependent protein kinase (PKG) inhibitor with inhibitory effects on PKA and PKC.KT5823 increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression and iodide ion ... |
|
T11038 |
Dibutyryl-cGMP sodium
|
Bt2cGMP sodium |
Others
|
|
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits [3H]-arachidonic acid release in ... |
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T61382 |
Fasudil dihydrochloride
|
|
|
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Fasudil dihydrochloride, also known as HA-1077 and AT877, is a nonspecific inhibitor of RhoA/ROCK. It exhibits inhibitory effects on protein kinases, including ROCK1 with a Ki value of 0.33 μM, as well as ROCK2, PKA, PKC... |
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T78007 |
Vasonatrin Peptide (VNP) TFA
|
|
|
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Vasonatrin Peptide (VNP) TFA, a chimeric compound derived from atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP), exhibits venodilating properties reminiscent of CNP, natriuretic effects akin to ANP, ... |
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T35459 |
Glycyl H-1152 hydrochloride
|
|
|
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Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and prol... |
