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T39008 |
PRMT5-IN-4
|
PRMT5-IN-4 |
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PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor. |
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T39809 |
PRMT5-IN-14
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PRMT5-IN-14 |
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PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations. |
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T40197 |
PRMT5-IN-11
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PRMT5-IN-11 |
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PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations. |
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T40202 |
PRMT5-IN-12
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PRMT5-IN-12 |
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PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 . |
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T39934 |
PRMT5-IN-13
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PRMT5-IN-13 |
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PRMT5-IN-13 is a selective inhibitor of protein arginine methyltransferase 5 (prmt5) . |
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T39993 |
PRMT5-IN-15
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PRMT5-IN-15 |
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PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM. |
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T40313 |
PRMT5-IN-9
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PRMT5-IN-9 |
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PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM. |
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T16577 |
PRMT5-IN-2
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Histone Methyltransferase
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PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5. |
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T12541 |
PRMT5-IN-1
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Histone Methyltransferase
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PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50). |
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T69430 |
PRMT5-IN-C17
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PRMT5-IN-C17 is a novel potent, selective, and cell active protein arginine methyltransferase 5 (PRMT5) inhibitor. |
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T62683 |
PRMT5-IN-3
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PRMT5-IN-3 is a PRMT5 inhibitor.PRMT5-IN-3 is a combined DNA damaging agent that is synthetically lethal to tumor cells. |
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T63103 |
PRMT5-IN-17
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PRMT5-IN-17 (Compound 6) is a PRMT5 inhibitor that exhibits antitumour activity. PRMT5, a protein arginine methyltransferase, is a novel anti-tumour target associated with epigenetic modifications. |
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T78152 |
PRMT5-IN-25
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Histone Methyltransferase
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PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1]. |
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T63860 |
PRMT5-IN-18
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PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours. |
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T61986 |
PRMT5-IN-21
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PRMT5-IN-21 (compound 1) is a potent inhibitor of cyclonucleoside PRMT5. |
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T60725 |
PRMT5-IN-10
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PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex. |
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T76413 |
PRMT5-IN-22
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PRMT5-IN-22 (compound 53), an inhibitor of protein arginine methyltransferase 5 (PRMT5), exhibits anti-tumor activity. As a protein arginine methyltransferase, PRMT5 represents a novel anti-tumor target associated with e... |
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T78172 |
PRMT5-IN-29
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Histone Methyltransferase
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PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1]. |
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T79035 |
PRMT5-IN-28
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Histone Methyltransferase
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PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processes including gene transcription, mRNA splicing, DNA repair, prot... |
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T63138 |
PRMT5-IN-16
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PRMT5-IN-16 (Compound 20) is a PRMT5 inhibitor with antitumour effects. PRMT5, a protein arginine methyltransferase, is a novel anti-tumour target associated with epigenetic modifications. |
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T72785 |
PRMT5:MEP50 PPI
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PRMT5:MEP50 PPI, a pioneering inhibitor of the PRMT5:MEP50 protein-protein interaction (PRMT5:MEP50 PPI), demonstrates anti-tumor and anti-proliferative effects in lung and prostate cancer cells. |
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T76414 |
PRMT5-IN-23
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PRMT5-IN-23 (compound 50), an inhibitor of protein arginine methyltransferase 5 (PRMT5), exhibits anti-tumor activity. As a novel anti-tumor target associated with epigenetic modification, PRMT5 belongs to the protein ar... |
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T61862 |
PRMT5-IN-19
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PRMT5-IN-19 (Compound 41) is a potent orally active PRMT5 inhibitor, exhibiting selectivity towards the SAM-binding pocket of PRMT5 with IC50 values of 23.9 nM (radioactive biochemical assay) and 47 nM (AlphaLISA assay).... |
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T79274 |
PRMT5-IN-31
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Histone Methyltransferase
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PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 and establishing key interactions with amino acid residues. It exhibits a... |
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T62815 |
PRMT5-IN-1 hydrochloride
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PRMT5 IN-1 hydrochloride (compound 9) is a hemiacetalamine, a potent inhibitor of the selective protein arginine methyltransferase 5 (PRMT5) with an inhibitory effect on PRMT5/MEP50 (IC50: 11 nM). PRMT5 IN-1 hydrochlorid... |
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T40254 |
MRTX-1719
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Histone Methyltransferase
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MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells. |
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T9575 |
MRTX9768
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Histone Methyltransferase
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MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors. |
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T14141 |
AGI-24512
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Others
,
Methionine Adenosyltransferase (MAT)
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AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in vitro. |
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T15767 |
LLY-283
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Histone Methyltransferase
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LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity. |
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T6076 |
EPZ015666
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GSK3235025 |
Histone Methyltransferase
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EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity. |
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T6857 |
HLCL-61 hydrochloride
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HLCL61,HLCL-61 HCL |
Apoptosis
,
Histone Methyltransferase
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HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. |
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T6853 |
GSK591
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GSK3203591,EPZ015866 |
Histone Methyltransferase
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GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM). |
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T5745 |
GSK3326595
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EPZ015938 |
Histone Methyltransferase
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GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.). |
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T9329 |
BRD0639
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Histone Methyltransferase
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BRD0639 is a pioneering inhibitor targeting the interaction between PRMT5 and its substrate adaptor. As a competitive inhibitor of the PRMT5 binding motif (PBM), BRD0639 facilitates the investigation of activities depend... |
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T11131 |
DW14800
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Histone Methyltransferase
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DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s. |
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T10850 |
CMP-5
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Others
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CMP-5 is an effective and selective small-molecule inhibitor of PRMT5. CMP-5 blocks EBV-driven B lymphocyte transformation and survival, but does not show this activity against PRMT1, PRMT4 and PRMT7 enzymes. During hist... |
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T40233 |
(Iso)-MS4322
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(Iso)-YS43-22,MS4322 (isomer),YS43-22 (isomer) |
Histone Methyltransferase
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(Iso)-MS4322 ((Iso)-YS43-22) is a selective and potent protein arginine methyltransferase 5 (PRMT5) degrader with potential anticancer activity that effectively reduces PRMT5 protein levels in MCF-7 cells and inhibits th... |
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T73494 |
TNG908
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TNG908, a MTAP-cooperative PRMT5 inhibitor capable of penetrating the blood-brain barrier, demonstrates 15-fold greater selectivity for MTAP cell lines over MTAP WT (wild type) cell lines. Its application is primarily in... |
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T67947 |
WDR5-0102
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Histone Methyltransferase
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WDR5-0102 is a compound that inhibits the WDR5-MLL1 interface (K dis = 7 μM, K d = 4 μM), selectively reducing MLL1 HMT activity without affecting the human H3K4 methyltransferase SETD7 or other HMTs, including G9a, EHMT... |
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T15624 |
JNJ-64619178
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Histone Methyltransferase
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JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer. |
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T19243 |
CMP-5 hydrochloride
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Others
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CMP-5 hydrochloride is a potent and selective PRMT5 inhibitor, while displays no activity against PRMT1/4/7 enzymes. It selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. |
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T28448 |
PR5-LL-CM01
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PR5-LL-CM01 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor in colorectal and pancreatic cancers. |
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T71767 |
WX2-43
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WX2-43 is a Novel potent PRMT5 specific inhibitor, specifically blocking KLF4-mediated transcription and cell survival, suppressing breast tumor progression. |
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T26836 |
BLL5 Maleate
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BLL5 Maleate is a first-in-class selective PRMT5 inhibitor, it blocks EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected. |
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T36981 |
GSK 591 dihydrochloride
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Potent and selective PRMT5 inhibitor (IC50 = 4 nM). Selective for PRMT5 over a panel of other PRMTs and lysine methyltransferases. Inhibits proliferation of mantle cell lymphoma (MCL) in vitro. To request the negative... |
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T36630 |
MRTX9768 hydrochloride
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MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor. MRTX9768 hydrochloride is a synthetic lethal-based inhibitor binding the PRMT5-MTA complex[1].
MRTX9768 inhibits SDMA and cell proliferation in HCT116 MT... |
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T15169 |
DS-437
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Others
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DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3. |
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T10967 |
DC_C66
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Others
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DC_C66 DC_C66 has good selectivity for CARM1, PRMT1 (IC50 = 21μM), PRMT6 (IC50 = 47μM) and PRMT5. It is a cell-permeable, selective co-activator related arginine methyltransferase 1 (CARM1) inhibitor with IC50 of 1.8 μM. |
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T79873 |
TNG-462
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Histone Methyltransferase
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TNG-462 (Compound 1143) is a PRMT5 inhibitor with oral activity, being investigated for use in MTAP-deficient and/or MTA-accumulating cancers [1]. |
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T70125 |
Pemrametostat succinate
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Pemrametostat succinate is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) that potently inhibits tumor growth in vitro and in vivo in animal models. |
