|
T1831 |
StemRegenin 1
|
SR1 |
AhR
,
Aryl Hydrocarbon Receptor
|
|
StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor. |
|
T23383 |
SR11237
|
SR 11237 |
Others
,
RAR/RXR
|
|
SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element. |
|
T6082 |
SSR128129E
|
SSR |
FGFR
|
|
SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 μM), but not affecting other related RTKs. |
|
T23389 |
SR1664
|
SR 1664 |
PPAR
|
|
SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPAR... |
|
T4407 |
SR17018
|
|
Opioid Receptor
|
|
SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM. |
|
T60037 |
SR15006
|
|
DNA/RNA Synthesis
|
|
SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM). |
|
T6994 |
SR12813
|
SR-12813,SR 12813,GW 485801 |
HMG-CoA Reductase
,
Autophagy
|
|
SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist. |
|
T22429 |
SR18662
|
|
DNA/RNA Synthesis
|
|
SR18662, an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM, reduces the viability of multiple colorectal cancer cell lines and induces apoptosis. |
|
T16928 |
SR144528
|
|
Cannabinoid Receptor
|
|
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM). |
|
T5163 |
SR1001
|
|
ROR
|
|
SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM). |
|
T28855 |
SSR126768A
|
SSR-126768A,SSR 126768A |
Oxytocin Receptor
|
|
SSR126768A is a novel and selective, orally active and potent oxytocin (OT) receptor antagonist with inhibitory effects on uterine contractions for the prevention of preterm labor. |
|
T12998 |
SR10067
|
|
Others
,
Autophagy
|
|
SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbα/β(IC50 of 160 and 170 nM for Rev-Erbβ and Rev-Erbα, respectively),has anxiolytic activity. |
|
T4594 |
SR1078
|
SR 1078 |
ROR
|
|
SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ. |
|
T28856 |
SSR180711 hydrochloride
|
SSR-180711A HCl,SSR-180711C HCl,SR-180711 HCl |
AChR
|
|
SSR180711 hydrochloride (SSR-180711A HCl) is a selective Alpha7 nicotinic acetylcholine partial agonist for the study of neurodegenerative and cognitive disorders. |
|
T24828 |
SR14150
|
SR-14150,SR 14150 |
|
|
SR14150 is a partial agonist of high-affinity NOP receptor. |
|
T28846 |
SR16835
|
AT-202,AT202,SR 16835,SR-16835 |
|
|
SR16835 is a NOP receptor agonist, with low-affinity bifunctional activity at the μ opioid receptor. |
|
T63206 |
SR12418
|
|
|
|
SR12418 is a specific REV-ERB synthetic ligand that acts on REV-ERBα (IC50: 68 nM) and REV-ERBβ (IC50: 119 nM) and can be used to study experimental autoimmune encephalomyelitis (EAE) and colitis. |
|
T13003 |
SSR128129E free acid
|
SSR free acid |
FGFR
|
|
SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1). |
|
T28845 |
SR142948A HCl
|
SR142948A,SR 142948A,SR-142948A,SR142948A hydrochloride |
|
|
SR 142948A is a non-peptide antagonist of neurotensin receptor. SR 142948A affects the expression of c-Fos and has properties of antipsychotic agent. SR 142948A blocks hypothermia and analgesia induced by neurotensin. It... |
|
T26223 |
SR1555 HCl
|
SR-1555,SR1555,SR 1555 |
|
|
SR1555 is a selective RORγ inverse agonist that inhibits the development and function of TH17 cells, a subset of T cells that have been involved in the pathology of several autoimmune diseases such as rheumatoid arthriti... |
|
T69671 |
SR1903 TFA
|
|
|
|
SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated rec... |
|
T12999 |
SR121566A
|
|
Others
|
|
SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa). |
|
T62239 |
HSR1304
|
|
|
|
HSR1304 (Compound 5d) is a potent inhibitor of NFκB, a multifunctional transcription factor involved in a wide range of human diseases (e.g. cancer, chronic inflammation). HSR1304 has potential for research in cancer dis... |
