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Search Results for " Squalene "

阻害剤

天然化合物

カタログ番号	製品名	別名	ターゲット
T81109	Squalene synthase-IN-1
	Squalene synthase-IN-1 (compound 1) is a potent antihyperlipidemic agent that inhibits Squalene Synthase and demonstrates exceptional antioxidant and anti-inflammatory activities. It significantly reduces both glucose an...
T4066	FIN56		Ferroptosis
	FIN56 is a specific inducer of ferroptosis.		Ferroptosis
T1497	Liranaftate	Piritetrate,M-732	Antifungal
	Liranaftate (Piritetrate) is a thiocarbamate and squalene epoxidase inhibitor with antifungal activity. Liranaftate inhibits fungal squalene epoxidase, an enzyme that plays a key role in the synthesis of sterol which is ...		Antifungal
T1217	Butenafine hydrochloride	KP363 (Hydrochloride),Butenafine HCl,KP-363	Antibiotic , Antifungal
	Butenafine hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, inhibiting the synthesis of sterols by inhibiting squalene epoxidase.		Antibiotic , Antifungal
TQ0115	NB-598		Antifungal
	NB-598 is an effective and competitive inhibitor of squalene epoxidase. It suppresses triglyceride biosynthesis through the farnesol pathway.		Antifungal
T11321	FR194738 free base		Antifungal
	FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.		Antifungal
T1543	Naftifine hydrochloride	Naftifungin,Naftifine HCl,Naftin,Exoderil	Hedgehog/Smoothened , Antibiotic , Antifungal
	Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its...		Hedgehog/Smoothened , Antibiotic , Antifungal
T83658	SQLE-IN-1		Antifungal
	SQLE-IN-1 is a squalene epoxidase (SQLE) inhibitor with anti-tumor activity. It can inhibit the proliferation and migration of liver cancer cell line Huh7, inhibit the production of cellular cholesterol, and increase the...		Antifungal
T12765	RPR107393 free base		Others
			Others
T25317	DF-461	DF 461
	DF-461 is an inhibitor of squalene synthase.
T24825	Squalestatin 2
	Squalestatin 2 is an inhibitor of squalene synthase.
T24710	Zaragozic acid C	L697350,L-697,350,L 697,350,L 697350,L-697350
	Zaragozic acid C is an effective inhibitor of squalene synthase.
T29189	YM-75440	YM75440
	YM-75440 is an squalene synthase inhibitor with oral activity.
T70435	BMS-187745
	BMS-187745 is a squalene synthase inhibitor.
T15709	Lapaquistat acetate	TAK-475	Others
	Lapaquistat acetate is a squalene synthase inhibitor. It also blocks the conversion of farnesyl diphosphate (FPP) to squalene. Lapaquistat acetate is used to Mevalonate Kinase Deficiency (MKD), it is effective at lowerin...		Others
T13371	YM-53601 free base		AMPK
	YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.		AMPK
T27646	J-104118	J 104118
	J-104118 potentially inhibits squalene synthase.
T24826	Squalestatin 3
	Squalestatin 3 is an inhibitor of squalene synthase.
T27231	E5700	E 5700,E-5700
	E5700 is a novel squalene synthase inhibitor with oral activity.
T12199L	NB-598 hydrochloride		Antifungal
	NB-598 hydrochloride is a competitive squalene epoxidase (SE) inhibitor.		Antifungal
T12199	NB-598 Maleate		Others
	NB-598 Maleate is a competitive squalene epoxidase (SE) inhibitor.		Others
T21365	Butenafine	KP363,KP 363,Mentax,KP-363,Butop
	Butenafine hydrochloride is a hydrochloride of butenafine, which inhibits squalene epoxidase to inhibit the synthesis of ergosterol, leading to the increased permeability of the cell membranes, allowing their contents to...
T30499	BMS-188494	UNII-F4W2579G7P
	BMS-188494 is a squalene synthase inhibitor used as an anti-cholesterol drug.
T23767	WC-9	WC 9
	WC-9 is a squalene synthase inhibitor. It acts by binding to TcSQS and HsSQS.
T11320	FR194738		Antifungal
			Antifungal
T26347	Zaragozic acid D
	Zaragozic acid D inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger.
T26345	YM-53601	YM53601
	YM-53601 is a squalene synthase activity inhibitor that acts by lowering cholesterol as well as triglycerides.
T26348	Zaragozic acid D(2)
	Zaragozic acid D(2) inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger.
T6702L	Terbinafine lactate	DRG-0286,Terbinafine hydrochloride,Lamisil Krem,SF 86-327 hydrochloride,Lamisil,Lamisil AT
	Terbinafine, a synthetic allylamine antifungal, inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway.
T35503	(±)-5,7-Dimethyltocol
	(±)-5,7-Dimethyltocol is a form of tocopherol. It has similar antioxidant activity to α-tocol, but lower activity than γ-tocol, in antioxidant assays using menhaden oil or squalene as substrates. It also increases microv...

Compounds

Squalene synthase-IN-1

Synonym: Piritetrate,M-732

Target: Antifungal

Butenafine hydrochloride

T1217

Synonym: KP363 (Hydrochloride),Butenafine HCl,KP-363

Target: Antibiotic, Antifungal

Naftifine hydrochloride

T1543

Synonym: Naftifungin,Naftifine HCl,Naftin,Exoderil

Target: Hedgehog/Smoothened, Antibiotic, Antifungal

Synonym: L697350,L-697,350,L 697,350,L 697350,L-697350

Synonym: E 5700,E-5700

Synonym: KP363,KP 363,Mentax,KP-363,Butop

Target:

BMS-188494

T30499

Synonym: UNII-F4W2579G7P

Synonym: DRG-0286,Terbinafine hydrochloride,Lamisil Krem,SF 86-327 hydrochloride,Lamisil,Lamisil AT

Target:

(±)-5,7-Dimethyltocol

T35503

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T4749	Squalene	Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene	Reactive Oxygen Species , Endogenous Metabolite , Antifungal
	Squalene (AddaVax) is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though there are botanical sources as well, including rice bran, wheat germ, and olives. All hi...
T75636	(E/Z)-Squalene	(E/Z)-Super Squalene,(E/Z)-AddaVax
	(E/Z)-Squalene ((E/Z)-AddaVax) regulates intracellular reactive oxidant species (ROS) production and induces apoptosis and necrosis in a concentration and time-dependent manner. (E/Z)-Squalene accumulates in the liver an...
TN5051	Squalene-2,3-diol		Others
	Squalene-2,3-diol is a natural product for research related to life sciences. The catalog number is TN5051 and the CAS number is 14031-37-9.		Others
TN1576	Diallyl disulfide		IL Receptor , NOS , NF-κB
	Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.		IL Receptor , NOS , NF-κB
T5613	Squalane	Dodecahydrosqualene,Perhydrosqualene	Others
	Squalane (Perhydrosqualene) is a naturally occurring lipid in both plants and animals. It is usually used as a moisturizer and emollient in cosmetics manufacturing.		Others
T6702	Terbinafine	Terbinex,SF 86-327,Lamisil,TDT 067	Antibacterial , Antibiotic , Antifungal
	Terbinafine (TDT 067) is a synthetic allylamine derivative with antifungal activity. Terbinafine exerts its effect through inhibition of squalene epoxidase, thereby blocking the biosynthesis of ergosterol, an important c...		Antibacterial , Antibiotic , Antifungal
T1411	Terbinafine hydrochloride	KWD 2019,Terbinafine HCl,TDT 067 hydrochloride	Antibacterial , Antibiotic , Antifungal
	Terbinafine hydrochloride (KWD 2019) is a synthetic allylamine derivative structurally related to naftifine. Terbinafine is active against dermatophytes.		Antibacterial , Antibiotic , Antifungal
TN5134	Tetrahydroxysqualene		Antifection
	Tetrahdroxysqualene shows antimycobacterial activity with an MIC of 10.0 microg/mL, while showing only modest cytotoxicity.		Antifection
T31520	Diplopterol
	Diplopterol is biosynthetic of squalene for use in acetobacter pasteurii in a cell-free system. It is a hopanoid and can be used as a substitute for sterols.