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T7530 |
PD146176
|
NSC168807 |
Ferroptosis
,
Lipoxygenase
,
Autophagy
|
|
PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology... |
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T0382 |
Eprodisate disodium
|
NC-503 |
Others
|
|
Eprodisate disodium (NC-503) is a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis. |
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T39740 |
Acoramidis hydrochloride
|
AG10 hydrochloride,Alxn2060 hydrochloride |
Others
|
|
Acoramidis hydrochloride (Alxn2060 hydrochloride) is an orally active and selective kinetic stabilizer of WT and V122I- TTR (transthyretin) . Acoramidis hydrochloride is used in the study for transthyretin amyloidosis. |
|
T9447 |
AG-10
|
Acoramidis |
Others
|
|
AG-10 (Acoramidis) is an orally active and selective kinetic stabilizer of TTR (transthyretin). AG-10 exhibits activity for WT and V122I-TTR. AG-10 is used in the study of transthyretin amyloidosis. |
|
T14283 |
Amyloid P-IN-1
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|
Beta Amyloid
|
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amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, and type 2 diabetes mellitus. |
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T111959 |
IFB-088 acetate
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|
|
|
IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein... |
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T38909 |
Inotersen sodium
|
ISIS-420915 sodium |
|
|
Inotersen sodium, also known as ISIS-420915 sodium, is a 2′-O-methoxyethyl-modified antisense oligonucleotide compound. It effectively inhibits transthyretin (TTR) protein production by targeting the TTR RNA transcript, ... |
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T39638 |
Eprodisate
|
|
|
|
Eprodisate is a novel compound specifically developed to disrupt the interactions between amyloidogenic proteins and glycosaminoglycans, effectively impeding the polymerization of amyloid fibrils and their deposition in ... |
|
T39304 |
Vutrisiran
|
ALN-TTRsc02 |
|
|
Vutrisiran (ALN-TTRsc02) is an investigational, liver-directed small interfering ribonucleic acid (siRNA) compound designed for research on transthyretin (TTR)-mediated amyloidosis. |
|
T38918 |
Revusiran
|
ALN-TTRSC |
|
|
Revusiran (ALN-TTRSC) is a first-generation short interfering RNA (siRNA) that specifically targets transthyretin (TTR) mRNA. It is utilized in TTR-mediated amyloidosis research. |
|
T79417 |
PITB
|
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|
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PITB, a selective and orally active transthyretin (TTR) aggregation inhibitor, is utilized in transthyretin amyloidosis (ATTR) disease research [1]. |
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T80801 |
WAY-612453
|
|
|
|
WAY-612453 is an active compound utilized in researching amyloid diseases and synucleinopathies. |
|
T78531 |
Anti-amyloid agent-1
|
|
|
|
Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1]. |
|
T76931 |
Birtamimab
|
|
|
|
Birtamimab (NEOD001) is a monoclonal antibody under investigation for its ability to selectively target and eliminate amyloid in the treatment of light chain amyloidosis [1]. |
|
T38804 |
Patisiran sodium
|
|
|
|
Patisiran sodium is a double-stranded small interfering RNA (siRNA) that selectively targets a specific sequence within the transthyretin (TTR) messenger RNA (mRNA). By doing so, it effectively blocks the hepatic synthes... |
|
T74645 |
Eplontersen
|
|
|
|
Eplontersen, a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide, targets transthyretin (TTR) mRNA to suppress the synthesis of both variant and wild-type TTR proteins. The accumulatio... |
|
TMIH-0552 |
Tauroursodeoxycholic Acid-d4 Sodium Salt
|
|
|
|
Tauroursodeoxycholic Acid-d4 Sodium Salt is a deuterated compound of Tauroursodeoxycholic Acid Sodium Salt. Tauroursodeoxycholic Acid Sodium Salt has a CAS number of 14605-22-2. Tauroursodeoxycholate, also known as ursod... |
