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T11723L |
JNJ-39758979
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Histamine Receptor
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JNJ-39758979 is a selective and high-affinity histamine H4 receptor antagonist (Kis: 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively). JNJ-39758979 functionally antagonizes histamine... |
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T1278 |
Astemizole
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Laridal,Histaminos,Paralergin |
Potassium Channel
,
Histamine Receptor
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Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to re... |
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T0370 |
Pheniramine maleate
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Daneral,Inhiston,Trimetose |
5-HT Receptor
,
Histamine Receptor
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Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re... |
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T21014 |
Thonzylamine hydrochloride
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Resistab,Thonzylamine HCl,Novohetramin,Neohetramine hydrochloride,Anahist |
AChR
,
Histamine Receptor
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Thonzylamine hydrochloride (Resistab) is an anticholinergic and antihistamine used as an antipruritic. |
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T21443 |
Prednicarbate
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Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D |
Others
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Prednicarbate (Hoe 777) is a Corticosteroid Hormone Receptor Agonist. Prednicarbate has antipruritic, anti-inflammatory, and vasoconstrictive properties. It also decreases the number of circulating lymphocytes by inhibit... |
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T0276 |
Hydrocortisone Valerate
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Westcort |
Glucocorticoid Receptor
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Hydrocortisone Valerate (Westcort) has anti-inflammatory, antipruritic and vasoconstrictive properties. |
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T7564 |
Chlorphenoxamine
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Contristamine |
Histamine Receptor
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Chlorphenoxamine (Contristamine) is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent. |
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T0270 |
Hydrocortisone 17-butyrate
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Cortisol 17-butyrate,Hydrocortisone butyrate |
Glucocorticoid Receptor
,
Annexin A
,
Adrenergic Receptor
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Hydrocortisone 17-butyrate (Cortisol 17-butyrate) is a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects. |
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T0460 |
Pramocaine hydrochloride
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Pramoxine hydrochloride,Pramoxine HCl |
Sodium Channel
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Pramocaine hydrochloride (Pramoxine HCl), a topical anesthetic, is served as an antipruritic. |
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T20802 |
Flumethasone pivalate
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Locacorten,NSC-107680,Lorinden,NSC 107680,NSC107680,Locorten |
Others
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Flumethasone pivalate (Locorten) has antipruritic, anti-inflammatory, and vasoconstrictive properties and can be used in studies about adrenocortical suppression, cutaneous atrophy, plasma transcortin binding, and telang... |
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T21361 |
Alclometasone dipropionate
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Vaderm,Sch 22219,Aclovate,Delonal |
Others
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Alclometasone dipropionate （Sch 22219） is a synthetic glucocorticoid, a steroidal compound with antiproliferative, anti-inflammatory, anti-allergic, antipruritic, and vasoconstrictive properties, which is used in the stu... |
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T1124 |
Flumethasone
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Flumetasone,RS-2177,NSC-54702 |
Glucocorticoid Receptor
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Flumethasone (RS-2177) is a glucocorticoid receptor agonist, with anti-inflammatory, antipruritic and vasoconstrictive properties. |
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T3282 |
Alimemazine hemitartrate
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Alimemazine Tartrate,Methylpromazine Tartrate,Trimeprazine tartrate,Trimeprazine hemitartrate |
Others
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Alimemazine hemitartrate (Trimeprazine hemitartrate) is aphenothiazine derivative that is used as an antipruritic. It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. |
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T0376 |
Crotamiton
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Eurax,Crotamitone,Veteusan |
Parasite
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Crotamiton (Eurax) is an antipruritic and a scabicidal agent available as a lotion or cream for topical use only. It is a colorless to slightly yellowish oil with a faint amine-like odor. It is miscible with methanol and... |
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T1198 |
Tetracaine hydrochloride
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Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl |
Calcium Channel
,
Sodium Channel
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Tetracaine hydrochloride (Amethocalne HCl) (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmology, and it has been use... |
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T1561 |
Clobetasol propionate
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Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,CCl 4725 |
Glucocorticoid Receptor
,
P450
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Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expression. This results in the synthesis of certain a... |
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T6529 |
Halobetasol propionate
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Halobetasol Propionate,Ulobetasol propionate,BMY-30056,CGP-14458 |
Phospholipase
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Halobetasol propionate (BMY-30056) is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses acr... |
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T23944 |
DA 5018
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DA-5018,DA5018 |
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DA 5018 is a capsaicin derivative and is also a new non-narcotic analgesic. It has an antipruritic effect. |
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T10281 |
Alimemazine
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Trimeprazine |
Others
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Alimemazine (Trimeprazine) is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist. Alimemazine also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. |
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T69516 |
Thenalidine tartrate
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Thenalidine is an antihistamine with anticholinergic properties used as an antipruritic drug. It was withdrawn from the US, Canadian, and UK markets due to a risk of neutropenia. Thenalidine is an antagonist of the H1-re... |
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T62460 |
INCB38579
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|
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INCB38579 is a selective, orally active, histamine H4 receptor (HH4R) antagonist that crosses the blood-brain barrier and acts on hH4R (IC50: 4.8 nM), mH4R (IC50: 42 nM), and rH4R (IC50: 32 nM). INCB38579 has anti-inflam... |
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T38323 |
A-943931 (hydrochloride hydrate)
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|
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A-943931 is a histamine H4receptor antagonist (Ki= 3.8 nM).1In vivo, A-943931 inhibits scratching induced by clobenpropit in mice (ED50= 26 μmoles/kg, i.p.).
1.Milicic, I., Witte, D.G., Miller, T.L., et al.Identification... |
