|
T9152 |
2-(2-Hydroxyphenyl)-1H-benzimidazole
|
|
Others
|
|
2-(2-Hydroxyphenyl)-1H-benzimidazole has been used as a catalyst for the synthesis of polymers and other materials. |
|
T7478 |
2-Chloro-1-(4-fluorobenzyl)benzimidazole
|
|
Reductase
|
|
2-Chloro-1-(4-fluorobenzyl)benzimidazole is an inhibitor of aldose reductase (ALR2). |
|
T4239 |
1,3-dimethyl-2-oxobenzimidazole-5-carbaldehyde
|
1,3-DIMETHYL-2-OXO-2,3-DIHYDRO-1H-BENZIMIDAZOLE-5-CARBALDEHYDE |
Others
|
|
1,3-Dimethyl-2-oxobenzimidazole-5-carbaldehyde serves as an intermediate. |
|
T28754 |
Sepin-1
|
Sepin 1,Sepin1,2H-Benzimidazole, 2,2-dimethyl-5-nitro-, 1,3-dioxide |
Others
|
|
Sepin-1 is a noncompetitive inhibitor of separase (IC50 = 14.8 µM). Sepin-1 can inhibit the growth of breast cancer xenograft tumors in mice and human cancer cell lines by inhibiting cell proliferation and inducing apopt... |
|
T9016 |
AI-10-47
|
1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47 |
Others
|
|
AI-10-47 (1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47) is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM). |
|
T77512 |
1H-Benzimidazole-6-carboxamide, N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-
|
|
Others
|
|
1H-Benzimidazole-6-carboxamide, N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]- may have antitumor activity. |
|
Fr12535 |
2-(Trifluoromethyl)benzimidazole
|
|
|
|
Compound Fr12535 is a useful organic compound for research related to life sciences. The catalog number is Fr12535 and the CAS number is 312-73-2. |
|
T9579 |
GLP-1 receptor agonist 9
|
|
Glucagon Receptor
|
|
1H-Benzimidazole-6-carboxylic acid is a GLP-1 receptor agonist. |
|
T3979 |
Emedastine
|
LY188695,Emadine |
Histamine Receptor
|
|
Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its... |
|
T3124 |
Carbendazim
|
Bavistin,Carbendazole,Mercarzole |
Antifungal
|
|
Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspec... |
|
T0662 |
2-Hydroxybenzimidazole
|
2-Benzimidazolinone |
Others
|
|
2-Hydroxybenzimidazole (2-Benzimidazolinone) is used as an intermediate in industry. |
|
T21642 |
4,5,6,7-Tetrabromobenzimidazole
|
|
|
|
4,5,6,7-Tetrabromobenzimidazole is a selective and ATP-competitive inhibitor of protein kinase CK2 [1]. |
|
T67503 |
5-Methoxy-2-benzimidazolethiol
|
|
|
|
5-Methoxy-2-benzimidazolethiol is a useful organic compound for research related to life sciences. The catalog number is T67503 and the CAS number is 37052-78-1. |
|
T6944 |
Thiophanate-Methyl
|
|
Antifungal
|
|
Thiophanate-Methyl (TM), a methyl benzimidazole carbamate (MBC) fungicide, |
|
T1141 |
Fenbendazole
|
Fenbendazol,Phenbendasol,Panacur |
Others
,
HIF/HIF Prolyl-Hydroxylase
,
Antibiotic
,
Parasite
|
|
Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine. |
|
T0714 |
Oxfendazole
|
RS-8858 |
Glucokinase
,
Microtubule Associated
,
Parasite
|
|
Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms. |
|
T4057 |
Hoechst 33258 trihydrochloride
|
Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258 |
Parasite
|
|
Hoechst 33258 trihydrochloride (Bisbenzimide) is a benzimidazole anti-filarial agent. it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication. it also interfe... |
|
T61107 |
Tilomisole
|
Wy 18251 |
Others
|
|
Tilomisole (Wy 18251) is an orally available benzimidazole thiazole with anti-inflammatory activity and immunomodulatory activity.Tilomisole is used in the study of cancer and inflammation. |
|
T6623 |
Oxibendazole
|
|
Apoptosis
,
Parasite
|
|
Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets. |
|
T73577 |
TJ08
|
|
Apoptosis
|
|
TJ08 is a 1,2,5-trisubstituted benzimidazole derivative with anticancer properties that effectively induces G1/S phase blockade while promoting apoptotic effects in a variety of cancer cells. |
|
T5840 |
Hoechst 33342
|
HOE 33342,bisBenzimide H 33342 |
Autophagy
|
|
Hoechst 33342 (bisBenzimide H 33342), is a Benzimidazole fluorescent dye and a Cell permeable fluorescent DNA stain; binds minor groove of AT-rich regions. HOE 33342 trihydrochlorde is used to quantify DNA in viable cell... |
|
T17006 |
TC-I 2014
|
|
TRP/TRPV Channel
|
|
TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50: 0.8 nM, 3.0 nM, and 4.4 nM for canine,... |
|
T1021 |
(R)-Lansoprazole
|
Dexlansoprazole,T 168390,TAK 390,R-(+)-Lansoprazole |
Proton pump
|
|
(R)-Lansoprazole (T 168390) is the R-isomer of lansoprazole and a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity.Lansoprazole (AG 1749) is a potent brain penetrant neutra... |
|
T2162 |
Maribavir
|
BW1263W94,GW257406X,Benzimidavir,1263W94 |
Others
,
HCV Protease
|
|
Maribavir (GW257406X) is an orally available benzimidazole riboside compound with activity against cytomegalovirus (CMV). Maribavir is a selective ATP competitor of the viral UL97 kinase, which is involved in viral nucle... |
|
T6929 |
Pantoprazole sodium
|
Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc |
Apoptosis
,
Others
,
Proton pump
,
HIF
,
Autophagy
|
|
Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters... |
|
T1756 |
Ilaprazole sodium
|
IY-81149 sodium |
Proton pump
,
TOPK
|
|
Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus... |
|
T79088 |
Chlamydia pneumoniae-IN-1
|
|
|
|
Chlamydia pneumoniae-IN-1 (compound 55), a benzimidazole derivative, exhibits potent antibacterial activity, inhibiting 99% of C. pneumoniae growth at a concentration of 10 μM and maintaining 95% viability of the host ce... |
|
T38361 |
GSK717
|
|
IL Receptor
,
NOD
|
|
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretio... |
|
T27484 |
GSK579289A
|
GSK-579289A,GSK 579289A |
|
|
GSK579289A is an inhibitor of benzimidazole thiophene. |
|
T26957 |
CAY10575
|
CAY-10575,CAY 10575 |
|
|
CAY10575, a benzimidazole analog IKK-ε inhibitor, inhibits IKK-ε with an IC50 value of ~15.8 µM. |
|
T3124L |
Carbendazim HCl
|
Lignasan,Carbendazim hydrochloride,Sandomil P |
|
|
Carbendazim HCl is a widely used, broad-spectrum benzimidazole fungicide and a metabolite of benomyl. |
|
T26813 |
BI-L 45XX
|
BI-L-45 XX,BI L 45 XX,BIL45XX |
|
|
BI-L 45XX, an anti-inflammatory benzimidazole derivative, has inhibitory effects on neutrophil function. |
|
T60448 |
Diethofencarb
|
|
|
|
Diethofencarb is a fungicide that is highly active against Botrytis cinerea and Benzimidazole-resistant strains of Botryis spp. Diethofencarb acts as fungal agrochemicals [1]. |
|
T20960 |
Luxabendazole
|
HOE 216V |
|
|
Luxabendazole is a benzimidazole carbamate broad-spectrum anthelmintic agent. It has proved to be effective against immature and adult stages of the major gastrointestinal nematodes, cestodes, and trematodes. |
|
T25716L |
Liarozole HCl
|
R75251,Liarozole hydrochloride,R 75251,R-75251 |
|
|
Liarozole HCl is a benzimidazole derivative with antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits CYP450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, leading to an incr... |
|
T30538 |
BMS-695735
|
CHEMBL459729,DNC008930,BMS 695735,BMS695735,BDBM27888 |
|
|
BMS-695735, a benzimidazole inhibitor of insulin-like growth factor-1 receptor, has broad-spectrum antitumor activity in vivo. It was found that BMS-695735 had strong inhibition of CYP3A4, induction of CYP3A4 mediated by... |
|
T62967 |
Anti-inflammatory agent 10
|
|
|
|
Anti-inflammatory agent 10 is a tilomisole-based benzimidazole-thiazole derivative that is orally active. anti-inflammatory agent 10 is more active against COX-2 enzymes than COX-1. |
|
T39515 |
PAD2-IN-1
|
PAD2-IN-1 |
|
|
PAD2-IN-1, a benzimidazole-based derivative, is an efficacious and specific inhibitor of protein arginine deiminase 2 (PAD2). Demonstrating remarkable selectivity, PAD2-IN-1 exhibits a 95-fold higher affinity for PAD2 in... |
|
T63435 |
PTP1B-IN-16
|
|
|
|
PTP1B-IN-16 is a promising and selective benzimidazole derivative and an inhibitor of protein tyrosine phosphatase 1B (PTP1B) (Ki: 12.6 μM).PTP1B-IN-16 can be used to study type 2 diabetes. |
|
T63023 |
PTP1B-IN-19
|
|
|
|
PTP1B-IN-19 (Compound 43) is a promising selective benzimidazole derivative as a protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 23.3 μM).PTP1B-IN-17 can be used to study type 2 diabetes. |
|
T63601 |
PAD2-IN-1 hydrochloride
|
|
|
|
PAD2-IN-1 hydrochloride is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor with superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold), and is a benzimidazole-based derivative. |
|
T72812 |
(R)-Tegoprazan
|
|
|
|
(R)-Tegoprazan, a benzimidazole derivative, serves as a potent inhibitor of kidney H+/K+-ATPase, demonstrating significant efficacy with an IC50 of 98 nM against canine kidney Na+/K+-ATPase. This compound shows promise f... |
|
T63021 |
PTP1B-IN-17
|
|
|
|
PTP1B-IN-17 (Compound 45) is a selective benzimidazole derivative with potential as a protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 30.2 μM).PTP1B-IN-17 can be used in the study of type 2 diabetes. |
|
T74845 |
Antimalarial agent 23
|
|
|
|
Antimalarial agent 23, a benzimidazole-based compound, exhibits potent antimalarial activity, demonstrated by its low IC50 values of 0.08 μM for PfNF54 and 0.10 μM for PfK1, respectively. This compound effectively inhibi... |
|
T79858 |
TIE-2/VEGFR-2 kinase-IN-3
|
|
|
|
TIE-2/VEGFR-2 kinase-IN-3, a benzimidazole derivative, serves as a potent inhibitor of the tyrosine kinase receptors TIE-2 and VEGFR-2, exhibiting IC50 values of 6.9 nM and 3.5 nM, respectively. This compound is useful f... |
|
T79859 |
TIE-2/VEGFR-2 kinase-IN-4
|
|
|
|
TIE-2/VEGFR-2 kinase-IN-4, a benzimidazole derivative, serves as a potent inhibitor of the tyrosine kinase receptors TIE-2 and VEGFR-2, exhibiting inhibitory concentration (IC50) values of 5.2 nM and 5.1 nM, respectively... |
|
TMIH-0187 |
Dexlansoprazole-d4
|
(R)-Lansoprazole-d4 |
|
|
Dexlansoprazole-d4 is a deuterated compound of Dexlansoprazole. Dexlansoprazole has a CAS number of 138530-94-6. Dexlansoprazole is the R-isomer of lansoprazole and a substituted benzimidazole prodrug with selective and ... |
|
T68225 |
Fc 11a-2
|
|
|
|
Fc 11a-2, a benzimidazole compound, functions as an orally active, potent inhibitor of the NLRP3 inflammasome. It effectively hinders the NLRP3 inflammasome formation by blocking caspase-1 activation and consequently the... |
|
T71055 |
Albendazole-d7
|
|
|
|
Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helmi... |
