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T2470 |
MDL-28170
|
Calpain Inhibitor III |
Cysteine Protease
,
Proteasome
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MDL-28170 (Calpain Inhibitor III) is a Cysteine protease. |
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T38931 |
Calpain Inhibitor-1
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Calpain Inhibitor-1 (compound 36) is a highly potent and selective inhibitor of Calpain 1 (Cal1), which is a cysteine protease. It exhibits an IC50 value of 100 nM and a Ki value of 2.89 μM. |
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T6583 |
MG-101
|
ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101 |
Cysteine Protease
,
Proteasome
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MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins. |
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T21949 |
Calpain Inhibitor XII
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(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor targeting calpain I (μ-calpain) with a Ki value of 19 nM. It exhibits lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM)... |
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T72439 |
Calpain Inhibitor XI
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Calpain Inhibitor XI, a reversible covalent inhibitor of calpain-1, is utilized in the research of neurodegenerative disorders. |
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T80551 |
Calpain inhibitor V
|
Mu-Val-HPh-FMK |
Antibiotic
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Calpain Inhibitor V (Mu-Val-HPh-FMK) is a cell-permeable, irreversible calpain inhibitor with demonstrated anti-chlamydial activity [1]. |
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T63391 |
Calpain Inhibitor-2
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Calpain Inhibitor-2 is a lipophilic calpain inhibitor, and they showed moderate to good anti-proliferative effects in vitro compared to melanoma cell lines (A-375 and B-16F1) and PC-3 prostate cancer cells. was able to i... |
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T14187 |
ALLM
|
Calpain inhibitor II |
Others
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ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2]. |
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T63708 |
Calpain-2-IN-1
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Calpain-2-IN-1 is a selective calpain-2 inhibitor that prolongs ERK activation and thus enhances learning and memory. |
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T28786 |
SJA6017
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SJA-6017,Calpain Inhibitor VI,Calpain-In-4,SJA 6017,Calpain Inhibitor 4 |
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SJA6017 is a inhibitor of calpain-1 (IC50 = 7.5 nM) and calpain-2 ( IC50 = 78 nM). SJA6017 also inhibits cathepsins B (IC50s = 15 nM) and cathepsins L (IC50s = 1.6 nM). SJA6017 reduces apoptotic cell death, preserves spi... |
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T78632 |
Z-LLY-FMK
|
Calpain Inhibitor IV |
Proteasome
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Z-LLY-FMK (Calpain Inhibitor IV) serves as an inhibitor of calpain, a family of proteases implicated in the apoptosis of various cell systems. Specifically, this compound suppresses intestinal cell apoptosis following co... |
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T2154 |
MG-132
|
Z-LLL-al,Z-Leu-Leu-Leu-CHO |
Apoptosis
,
Proteasome
,
Autophagy
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MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induces apoptosis. |
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T9710 |
Dazcapistat
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Cysteine Protease
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Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively. |
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T2493 |
PD 151746
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Cysteine Protease
,
Proteasome
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PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calp... |
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T6432 |
Calpeptin
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Apoptosis
,
Cysteine Protease
,
Proteasome
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Calpeptin is a potent, cell-permeable calpain inhibitor. |
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TP2056L |
Acetyl-Calpastatin (184-210)(human) acetate
|
Acetyl-Calpastatin (184-210) (human) acetate(123714-50-1 Free base ) |
Cysteine Protease
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Acetyl-Calpastatin (184-210)(human) acetate is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively. |
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T60150 |
(1S,2R)-Alicapistat
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Cysteine Protease
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(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications for Alzheimer's disease (AD) therapy [1]. This compound ef... |
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T6040 |
Aloxistatin
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E64d,Loxistatin,E64c ethyl ester |
SARS-CoV
,
Cysteine Protease
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Aloxistatin (E64d) is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with... |
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T36352 |
Suc-Leu-Tyr-AMC
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Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease) that is used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; em... |
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T3525 |
PD150606
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Cysteine Protease
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PD150606 is a selective nonpeptide calpain inhibitor with neuroprotective activity that inhibits μ-calpains and m-calpains.
Inhibits erythrocyanine-induced Ca2+ efflux and interferes with excitotoxicity-dependent motor n... |
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T80103 |
Z-Leu-Tyr-Chloromethylketone
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Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1]. |
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TP2056 |
Acetyl-Calpastatin(184-210)(human)
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Acetyl-Calpastatin (184-210) (human) |
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Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio. |
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T68728 |
EP 459
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EP 459 is a thiol and calpain protease inhibitor. |
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T25011 |
AK-295
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CX295,CX 295,AK295,CX-295 |
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AK 295, also known as CX 295, is a dipeptide inhibitor of alpha-ketoamide calpain. |
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T36854 |
Pheleuin
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Pheleuin is a pyrazinone derivative synthesized from a dipeptide aldehyde. Although the biological activity of this compound has not been reported, similar diketopiperazines are known to inhibit calpain and/or regulate S... |
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T13486 |
Neurodegenerative Disorder-Targeting Compound 1
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Others
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Neurodegenerative Disorder-Targeting Compound 1 is an inhibitor of calpain [1]. |
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T23596 |
A-933548
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A933548,A 933548 |
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A-933548 is a potent Calpain inhibitor. A-933548 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays. |
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T25009 |
AK 275
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AK275,AK-275 |
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AK 275 is a calpain inhibitor that prevents degradation of cytoskeletal and myelin proteins in spinal cord in vitro. |
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T23598 |
A-953227
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A 953227,A953227 |
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A-953227 is a highly effective and selective inhibitor of calpain. A-953227 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays. |
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T83527 |
(Rac)-Neurodegenerative Disorder-Targeting Compound 1
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(Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor. |
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T75794 |
Acetyl-Calpastatin(184-210)(human) TFA
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Acetyl-Calpastatin(184-210)(human) TFA, a potent, selective, and reversible inhibitor of calpain, demonstrates Ki values of 0.2 nM for µ-calpain and 6 μM for cathepsin L, indicating high specificity and efficacy in inhib... |
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T80241 |
Calpastatin subdomain B
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Proteasome
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Calpastatin subdomain B is a bioactive peptide that inhibits calpain activity. |
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T76364 |
Ac-Leu-Leu-Norleucinol
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Ac-Leu-Leu-Norleucinol (ALLN), a calpain inhibitor, is employed in the research of Acetaminophen-induced acute liver damage. It effectively reduces levels of glutamic-oxalacetic transaminase (ALT) and glutamic-pyruvic tr... |
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T68547 |
SNJ-1945
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SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) ... |
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T83406 |
2,3-Diphospho-D-glyceric acid pentasodium salt
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2,3-DPG pentasodium salt |
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2,3-Diphospho-D-glyceric acid pentasodium salt is a highly anionic polyphosphorus compound located within the concave center of red blood cells, where it decreases oxygen affinity by binding to hemoglobin. This endogenou... |
