del19 | TargetMol

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カタログ番号	製品名	別名	ターゲット
T5462	Almonertinib	HS-10296	EGFR
	Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.		EGFR
T5675	Almonertinib hydrochloride	HS-10296 hydrochloride	EGFR
	Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.		EGFR
T10534	BI-4020		EGFR
			EGFR
T4485	Lazertinib	Lazertinib (YH25448),GNS-1480,YH25448	EGFR
	Lazertinib (GNS-1480) is an effective, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild type EGFR respectively...		EGFR
T64255	EGFR-IN-48
	EGFR-IN-48 is a potent, orally active EGFR inhibitor that acts on EGFRd19/TM/CS (IC50: 0.193 nM), EGFRLR/TM/CS (IC50: 0.251 nM), EGFRWT (IC50: 10.4 nM). EGFR-IN-48 is also able to inhibit EGFR-IN-48 also inhibits the pro...
T73165	EGFR-IN-73		EGFR
	EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].		EGFR
T63857	EGFR-IN-24
	EGFR-IN-24 is a potent inhibitor of EGFR and inhibits EGFR (del19/T790M/C797S) and EGFR (L858R/T790M/C797S).
T73101	EGFR-IN-25
	EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.
T73104	EGFR-IN-23
	EGFR-IN-23, identified as compound 8 in WO2021244502A1, is a potent EGFR tyrosine kinase inhibitor (TKI) demonstrating an inhibitory concentration (IC50) of 8.05 nM against the BaF3/EGFR-DEL19/T790M/C797S cell line.
T79775	EGFR-IN-89		EGFR
	EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM against Del19/T790M/C797S mutations, and demonstrating greater selectivi...		EGFR
T35334	CH7233163		EGFR
	CH7233163 is a useful organic compound for research related to life sciences and the catalog number is T35334.		EGFR
T74524	PROTAC EGFR degrader 5
	PROTAC EGFR Degrader 5 (Compound 10), a potent degrader of EGFR Del19 in HCC827 cells, achieves this with a DC50 of 34.8 nM. This compound effectively induces apoptosis in HCC827 cells and causes cell cycle arrest in the...
T74525	PROTAC EGFR degrader 6
	PROTAC EGFR degrader 6 is a potent PROTAC EGFR degrader that effectively reduces EGFR Del19 levels in HCC827 cells, exhibiting a DC50 of 45.2 nM. It notably promotes apoptosis and induces G1 phase arrest in HCC827 cells ...
TQ0255	Olafertinib	CK-101,EGFR-IN-3,RX-518	EGFR
	Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.		EGFR
T9865	Almonertinib mesylate		EGFR
	Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer st...		EGFR
T3621	Brigatinib	AP-26113	EGFR , FLT , ROS , IGF-1R , ALK
	Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.		EGFR , FLT , ROS , IGF-1R , ALK
T74515	PROTAC EGFR degrader 4
	PROTAC EGFR degrader 4 is a potent molecule designed to target and degrade mutant EGFR, showcasing its effectiveness by inducing degradation of EGFR del19 and EGFR L858R/T790M with DC50 values of 0.51 nM and 126 nM, resp...
T78788	EGFR-IN-82		EGFR
	EGFR-IN-82 (Compound 8a) is a potent, orally active inhibitor of EGFR, exhibiting IC50 values of 0.09 nM for EGFR L858R/T790M/C797S and 0.06 nM for EGFR Del19/T790M/C797S. It lacks significant inhibitory effects on EGFR ...		EGFR