Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約5 days | ¥ 21,500 |
5 mg | 約5 days | ¥ 45,000 |
10 mg | 約5 days | ¥ 75,500 |
25 mg | 約5 days | ¥ 130,000 |
50 mg | 約5 days | ¥ 182,000 |
説明 | Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR. |
ターゲット&IC50 | EGFR (T790M):0.37 nM (IC50), EGFR (del19/T790M):0.214 nM (IC50), EGFR (L858R/T790M):0.29 mM (IC50) |
In vitro | HS-10296 hydrochloride is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC[1]. |
別名 | HS-10296 hydrochloride |
分子量 | 562.1 |
分子式 | C30H36ClN7O2 |
CAS No. | 2134096-03-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (148.25 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Almonertinib hydrochloride 2134096-03-8 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR HS10296 non-small inhibit oral cancer lung HS-10296 hydrochloride del19 antineoplastic HS-10296 mutations Epidermal growth factor receptor L861Q HS 10296 Hydrochloride G719X Inhibitor NSCLC HS-10296 Hydrochloride Almonertinib Hydrochloride ErbB-1 HS10296 Hydrochloride L858R cell Almonertinib HS 10296 HER1 inhibitor