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T1476 |
Pramipexole
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SND 919 |
Dopamine Receptor
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|
Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not... |
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T23146 |
PHA 568487 free base
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PHA 568487 |
AChR
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The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia... |
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T6951 |
Pramipexole dihydrochloride hydrate
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Pramipexole 2HCl Monohydrate,Mirapex |
Dopamine Receptor
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|
Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and su... |
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T8498 |
EIDD-1931
|
Beta-d-N4-hydroxycytidine |
Virus Protease
,
HCV Protease
,
SARS-CoV
,
Topoisomerase
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|
EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity.It inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in Vero 76 cells, Middle East respiratory syndr... |
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T70540 |
Pinokalant
|
LOE-908 |
SARS-CoV
,
TRP/TRPV Channel
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Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischem... |
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T35689 |
MTP 131 acetate
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Others
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MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... |
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T16902 |
SMND-309
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Others
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SMND-309 is a metabolite of salvianolic acid B. It also shows neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats. |
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T70451 |
Blancoxanthone
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|
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Blancoxanthone is a molecule isolated from plants could also be potential drug candidates against COVID-19. Moreover, these could also show promising inhibitory effects against influenza-parainfluenza viruses, respirator... |
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T28414 |
Piclozotan
|
SUN-N-4057,SUN4057,SUNN-4057,SUN-4057,SUNN4057 |
5-HT Receptor
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|
Piclozotan (anhydrous), a 5-HT1A receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) model, ameliorating motor complications in patients with advan... |
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T71211 |
Rizatriptan-d6 benzoate salt
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Rizatriptan-d6 is intended for use as an internal standard for the quantification of rizatriptan by GC- or LC-MS. Rizatriptan is an agonist of the serotonin
receptor subtypes 5-HT1B and 5-HT1D. It is selective for 5-H... |
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T83730 |
Tat-M2NX TFA
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|
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Tat-M2NX, a peptide antagonist of transient receptor potential melastatin 2 (TRPM2), blocks hydrogen peroxide-induced calcium influx in HEK293 cells expressing human TRPM2 at concentrations between 25 to 100 µM. In male ... |
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T83695 |
MOG Peptide (human, bovine) acetate
|
Myelin Oligodendrocyte Glycoprotein Peptide |
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|
Myelin oligodendrocyte glycoprotein (MOG) peptide, a truncated form of MOG located on the extracellular myelin sheath surface, interacts with antigen serotype HLA-DR2 to mitigate effects of ischemic stroke induced by mid... |
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T83777 |
LAU-0901
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|
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LAU-0901, a platelet-activating factor (PAF) receptor antagonist, demonstrates efficacy in reducing infarct volume and enhancing neurological function in rats subjected to middle cerebral artery occlusion (MCAO)-induced ... |
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T36570 |
KUS121
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|
|
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KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, ... |
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T82504 |
EE epitope
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|
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EE epitope, a biologically active peptide, is a fragment (314 to 319 amino acids) of the middle T antigen from mouse polyomavirus and is frequently utilized as an epitope tag. Pyroglutamyl (pGlu) peptides, which can aris... |
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T83729 |
Tat-CIRP TFA
|
Tat-Cold-inducible RNA Binding Protein |
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Tat-CIRP, a peptide inhibitor, impedes the protein-protein interaction between myeloid differentiation 2 (MD-2), also known as lymphocyte antigen 96 (LY96), and cold-inducible RNA binding protein (CIRP) by binding to MD-... |
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T83731 |
Tat-CBD3 TFA
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|
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Tat-CBD3 is a chemical compound inhibiting the interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2), as well as the interaction between CRMP2 and the NMDA ... |
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T83727 |
Tat-NTS Peptide TFA
|
Tat-Nuclear Translocation Signal Peptide |
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Tat-NTS peptide, a cell-penetrating compound, comprises the HIV-1 Tat protein transduction domain fused with a 10-amino acid sequence (residues 228-237) from the repeat III domain of annexin A1, serving as a nuclear tran... |
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T83825 |
Trofinetide acetate
|
NNZ-2566 |
|
|
Trofinetide, derived from the neuroprotective tripeptide Gly-Pro-Glu (an N-terminal sequence of insulin-like growth factor-1, IGF-1), shows promise in various neuroprotective models. At a concentration of 10 nM, it mitig... |
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T83682 |
Tat-Gap 19 TFA
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|
|
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Tat-Gap 19, a peptide inhibitor of connexin43 (Cx43) hemichannels, is derived from the HIV-1 Tat protein transduction domain fused with a nine-amino acid sequence from Cx43 residues 128-136. This compound, at a concentra... |
