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T24778 |
sEH-IN-12
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sEH inhibitor 12,sEH-inhibitor-12 |
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sEH-IN-12 is an effective inhibitor of the enzyme soluble epoxide hydrolase (sEH). |
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T60358 |
sEH inhibitor-7
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Epoxide Hydrolase
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sEH inhibitor-7 is a soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in human and mouse with IC 50 s of 6.2 μM and 0.15 μM, respectively. sEH inhibitor-7 is associated with anti-inflammatory active molecules. |
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T38367 |
CAY10640
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sEH inhibitor-1 |
Epoxide Hydrolase
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CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4 and 5.3 nM, respectively. |
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T63536 |
Dual FAAH/sEH-IN-1
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FAAH
,
Epoxide Hydrolase
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Dual FAAH/sEH-IN-1 is a dual inhibitor of sEH (soluble epoxide hydrolase) (IC50: 9.6 nM) and FAAH (fatty acid amide hydrolase) (IC50: 7 nM) with high affinity and anti-inflammatory activity. |
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T63700 |
sEH inhibitor-4
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sEH inhibitor-4 (compound B15) has been identified as a potent soluble epoxide hydrolase (SEH) inhibitor with a remarkable inhibitory potency of 0.03 ± 0.01 nm. Intensive structural modification efforts led to the discov... |
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T64291 |
sEH inhibitor-1
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sEH inhibitor-1 (compound TCPU) is a potent, orally active inhibitor of soluble epoxide hydrolase (sEH) with IC50 values of 0.4 and 5.3 nM for human and murine she, respectively. |
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T79258 |
sEH inhibitor-16
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Epoxide Hydrolase
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sEH Inhibitor-16, a potent soluble epoxide hydrolase (sEH) inhibitor, exhibits an IC50 of 2 nM. It diminishes inflammatory damage associated with cerulein-induced acute pancreatitis (AP) in mice, making it suitable for i... |
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T62425 |
sEH inhibitor-3
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sEH inhibitor-3 (compound 35) is a potent, orally active inhibitor of soluble epoxide hydrolase (sEH) that acts on human sEH (Ki: 0.75 nM). |
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T61541 |
sEH inhibitor-6
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sEH inhibitor-6 (Compound 3g) is a highly potent soluble epoxide hydrolase (sEH) inhibitor, exhibiting an IC 50 value of 0.5 nM [1]. |
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T64136 |
sEH inhibitor-5
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sEH inhibitor-5 is a potent inhibitor of sEH (soluble epoxide hydrolase) (IC50: 0.1 nM). |
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T61894 |
sEH inhibitor-2
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SEH inhibitor-2 (compound 5l) is a soluble epoxide hydrolase (sEH) inhibitor with oral activity (IC50=0.9 nM), and the predicted oral absorption percentage is 71.2-88.4%. SEH inhibitor-2 can maintain a high concentration... |
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T72698 |
sEH inhibitor-14
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sEH inhibitor-14, a benzoxazolone-5-urea analogue, acts as an efficient soluble Epoxide Hydrolase (sEH) inhibitor, demonstrating significant activity with an IC50 value of 0.39 nM. |
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T72874 |
sEH/AChE-IN-2
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sEH/AChE-IN-2 and acetylcholinesterase ( AChE ). sEH/AChE-IN-2 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-2 has the potential for the research of Alzheimer's disease (AD) . |
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T72875 |
sEH/AChE-IN-3
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sEH/AChE-IN-3 (15) serves as a dual inhibitor targeting both soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE), demonstrating potent activity and the ability to cross the blood-brain barrier (BBB). It exhib... |
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T64181 |
sEH/AChE-IN-1
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sEH/AChE-IN-1 (Compound 12a) is a dual inhibitor of soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-1 has a cumulative effect against neuroinflammation and memory impairment. sEH/AChE-IN-1 ha... |
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T81181 |
sEH/FLAP-IN-1
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FLAP
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sEH/FLAP-IN-1 (Compound 46A) serves as a dual inhibitor targeting both sEH and FLAP. It effectively suppresses 5-LOX product formation with an EC50 of 11 nM in SACM-stimulated PBMCs and also inhibits sEH activity (EC50: ... |
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T72876 |
sEH/AChE-IN-4
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sEH/AChE-IN-4 -15 is a potent, blood-brain barrier-penetrating dual inhibitor targeting soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). It demonstrates notable inhibition efficacy, with IC50 values of 3.... |
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T63398 |
COX-2/sEH-IN-1
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COX-2/sEH-IN-1 is an orally active dual inhibitor of COX-2 (IC50: 1.24 μM) and sEH (IC50: 0.40 μM), a soluble epoxide hydrolase. COX-2/sEH-IN-1 increases anti-inflammatory effects and significantly reduces cardiovascular... |
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T83857 |
Soluble Epoxide Hydrolase PROTAC 1a
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sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a |
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Soluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) comprising a cereblon ligand linked to the sEH inhibitor t-TUCB via a linker, promoting selective sEH degradation and inhibiting its h... |
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T7898 |
AUDA
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Epoxide Hydrolase
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AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively) |
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T17158 |
Trans-AUCB
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t-AUCB |
Epoxide Hydrolase
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trans-AUCB (t-AUCB) is an effective and selective soluble epoxide hydrolase inhibitor (IC50s: 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively). |
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T10900 |
CUDA
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PPAR
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Epoxide Hydrolase
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CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR... |
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T11147 |
EC5026
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BPN-19186 |
Epoxide Hydrolase
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EC5026 (BPN-19186) has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators. |
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T82929 |
AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG
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The compound AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG facilitates bone ossification and has potential applications in the study of conditions associated with osteogenic insufficiency or diminished bone mineral densi... |
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T124894 |
Bursehernin
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Bursehernin is a useful organic compound for research related to life sciences and the catalog number is T124894. |
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T12580 |
PTUPB
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COX
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Epoxide Hydrolase
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PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively). |
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T15430 |
GSK2256294A
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GSK 2256294 |
Others
,
Epoxide Hydrolase
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GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively. |
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T7199 |
TPPU
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Epoxide Hydrolase
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TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8 nM, respectively) |
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T77594 |
VU534
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FAAH
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Phospholipase
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Epoxide Hydrolase
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VU534 is a NAPE-PLD agonist with an EC50 of 0.30 μM.VU534 is a dual inhibitor of FAAH and sEH, with an IC50 of 1.2 μM for sEH.VU534 is used in diseases related to cardiometabolism. |
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T23044 |
N,N'-Dicyclohexylurea
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DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582 |
Epoxide Hydrolase
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N,N'-Dicyclohexylurea (AURORA KA-3582) is a soluble epoxide hydrolase (sEH) inhibitor. |
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T8315 |
1-Cyclohexyl-3-dodecyl urea
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CDU,N-Cyclohexyl-N-dodecyl urea,NCND |
Epoxide Hydrolase
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1-Cyclohexyl-3-dodecyl urea (NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. |
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T8844 |
Diflapolin
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Others
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FLAP
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Epoxide Hydrolase
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Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. |
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T14557 |
BI-1935
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Epoxide Hydrolase
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BI-1935 is an inhibitor of soluble epoxide hydrolase (sEH). For diseases related to cardiovascular disease. |
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T9832 |
(Rac)-EC5026
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Urea, N-[3-fluoro-4-(trifluoromethoxy)phenyl]-N'-[1-(2-methyl-1-oxobutyl)-4-piperidinyl]- |
Epoxide Hydrolase
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(Rac)-EC5026 ((Rac)-BPN-19186) is a potent piperidine inhibitor of soluble epoxide hydrolase (sEH) with Ki of 0.06 nM. (Rac)-EC5026 can be used for the research of Parkinson's disease and dementia with Lewy Bodies (DLB) ... |
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T12974 |
Soluble epoxide hydrolase inhibitor
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Others
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Soluble epoxide hydrolase inhibitor is a soluble epoxide hydrolase inhibitor (human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4). |
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T13042 |
SWE101
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Others
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SWE101 is a potent human and rat soluble epoxide hydrolase (sEH)-P inhibitor(IC50s of 4 μM and 2.8 μM, respectively). |
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T82452 |
Epoxy Fluor 7
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Epoxy Fluor 7, a fluorescent substrate specific to soluble epoxide hydrolase (sEH), is utilized in the measurement of sEH activity through its hydrolysis-induced fluorescence in both human and mouse enzymes. |
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T36074 |
S-NEPC
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Cytochrome P450 metabolites of arachidonic acid, such as 11(12)-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) cata... |
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T70329 |
SH-11037
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SH-11037 is a novel potent seh inhibitor, effectively blocking key angiogenic properties of human retinal endothelial cells (hrecs), inhibiting choroidal sprouting and significantly suppressing cnv lesion volume |
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T35457 |
(±)12(13)-DiHOME
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(±)12(13)-DiHOME,Isoleukotoxin diol |
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(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME , a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin. [1] It is formed from 12(13)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils... |
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T83773 |
Prostaglandin E2 Inhibitor 3
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PGE2 Inhibitor 3 |
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Prostaglandin E2 (PGE2) inhibitor 3 is a selective inhibitor targeting microsomal prostaglandin E synthase-1 (mPGES-1; IC50 = 0.2 µM), demonstrating greater selectivity for mPGES-1 over COX-1, COX-2, 5-lipoxygenase (5-LO... |
