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T22419 |
S-Methylisothiourea sulfate
|
(S)-Methylisothiourea sulfate |
NOS
,
NO Synthase
,
HSV
|
|
S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1]. |
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T37292 |
M62812
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|
TLR
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|
TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic sh... |
|
TP1412 |
RNAIII-inhibiting peptide TFA
|
RNAIII-inhibiting peptide(TFA) |
Antibacterial
|
|
RNAIII-inhibiting peptide TFA (RNAIII-inhibiting peptide(TFA))(228544-21-6 free base) inhibits S. aureus, effective in the diseases such as cellulitis, keratitis, septic arthritis, osteomylitis and mastitis. |
|
T76251L |
Ac-FEID-CMK TFA
|
|
Pyroptosis
|
|
Ac-FEID-CMK TFA is a selective zebrafish GSDMEb-derived peptide inhibitor that reduces mortality and renal injury in infectious shock.Ac-FEID-CMK TFA inhibits pyroptosis in vivo, attenuates septic AKI (acute kidney injur... |
|
T13920L |
Terlipressin Acetate
|
Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous |
Vasopressin Receptor
|
|
Terlipressin Acetate, a highly selective vasopressin V1 receptor agonist, on oxygen and glucose deprivation/re-oxygenation (OGD/R)-induced damage in intestinal epithelial cells (IEC-6).Terlipressin acetate exerts anti-in... |
|
T10492 |
BD-AcAc 2
|
Ketone Ester |
Reactive Oxygen Species
|
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|
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T21967 |
MEG hemisulfate
|
Mercaptoethylguanidine hemisulfate |
NOS
|
|
MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 μM for iNOS, 110 μM for ecNOS, and 60 μM for bNOS i... |
|
T28921 |
Tanogitran
|
BIBT 986,BIBT986,BIBT-986 |
|
|
Tanogitran, a coagulation factor Xa inhibitor, is used potentially for the treatment of septic shock. |
|
T70480 |
FPL-65447 hydrochloride
|
|
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FPL-65447 hydrochloride is a selective D1 receptor agonist that has potential for the acute treatment of renal and cardiac failure and of sepsis and septic shock. |
|
T76733 |
Enibarcimab
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|
|
|
Enibarcimab is a humanized murine monoclonal immunoglobulin G1 (IgG1) antibody, potentially applicable in the research of acute heart failure, COVID-19 infections, and septic shock [1]. |
|
T78802 |
SIRT5 inhibitor 6
|
|
Sirtuin
|
|
SIRT5 Inhibitor 6 is a potent, selective, and substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 3.0 μM, and demonstrates therapeutic potential for treating septic acute kidney injury (AKI) in vivo [1]. |
|
T73353 |
NOS-IN-3
|
|
|
|
NOS-IN-3 is a potent, selective, imidamide derived NOS inhibitor with an IC 50 against iNOS of 4.6 µM, without inhibiting eNOS . NOS-IN-3 has little toxicity and can be studied in the treatment of inducible isoform invo... |
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T78561 |
M62812 free base
|
|
|
|
M62812 (free base), a Toll-like receptor 4 (TLR4) signal transduction inhibitor, suppresses activation of endothelial cells and leukocytes and prevents lethal septic shock in mice. It is utilized in sepsis research [1]. |
|
T82621 |
D359-0396
|
|
NOD-like Receptor (NLR)
|
|
D359-0396 is an orally active NLRP3 inflammasome inhibitor that mitigates pyroptosis and reduces IL-1β release in macrophages by inhibiting the oligomerization of NLRP3, ASC, and the cleavage of GSDMD. This compound is e... |
|
T37302 |
PCTR3
|
|
|
|
Protein conjugates in tissue regeneration 3 (PCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutath... |
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T76251 |
Ac-FEID-CMK
|
|
|
|
Ac-FEID-CMK, a potent peptide inhibitor derived from zebrafish-specific GSDMEb, effectively reduces mortality and kidney injury during septic shock by inhibiting pyroptosis and mitigating acute kidney injury (AKI) in viv... |
|
T79733 |
NLRP3-IN-20
|
|
NOD-like Receptor (NLR)
|
|
NLRP3-IN-20 (compound 11) is an orally administered inhibitor targeting the NLRP3 inflammasome, exhibiting potent inhibition with an IC50 of 25 nM against IL-1β secretion. It possesses excellent pharmacokinetic propertie... |
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T35598 |
Neuromedin U-25 (human) (trifluoroacetate salt)
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Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-med... |
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T82189 |
HMGB1-IN-2
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|
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HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM in RAW264.7 cells. At a concentration of 30 μM, HMGB1-IN-2 reduces... |
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T35406 |
α-MSH TFA
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|
|
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α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocyt... |
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T38309 |
LL-37 amide (trifluoroacetate salt)
|
|
|
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LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D... |
