|
T9235 |
GW604714X
|
2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- |
Mitochondrial Metabolism
|
|
GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitochondrial respiration supported by pyruvate |
|
T21659 |
AZ 11645373
|
3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE |
P2X Receptor
|
|
AZ 11645373 (3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE) is a highly selective and potent human P2X7 receptor antagonist that has no effect on mouse/rat P2X7 receptor. |
|
T9229 |
Pim-1/2 kinase inhibitor 1
|
|
Pim
|
|
Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim ... |
|
T22386 |
NSC 31206
|
2,4-Thiazolidinedione,5-[(4-hydroxy-3-methoxyphenyl)methylene]- |
Others
|
|
NSC 31206 is a bioactive chemical. |
|
T22708 |
Darglitazone
|
CP-86325 |
PPAR
|
|
Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions. Darglitazone is effective in controlling blood glucose and lipid metabolism. |
|
T2607 |
MSDC 0160
|
CAY10415,Mitoglitazone,MSDC0160,MSDC-0160 |
Others
,
IGF-1R
,
Mitochondrial Metabolism
|
|
MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease. |
|
T27841 |
Lobeglitazone Sulfate
|
CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang |
NOD
|
|
Lobeglitazone Sulfate（CKD-501 Sulfate） is a novel thiazolidinedione with anti-inflammatory activity that inhibits LPS-induced NLRP3 inflammasome activation and hepatic inflammation, and can be used in the study of type 2... |
|
T22387 |
NSC 55655
|
5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione |
Others
|
|
NSC 55655 (5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione) possesses antimicrobial and antioxidant activities and inhibits the proliferation of B. subtilis, S. aureus, K. pneumonia, E. coli, S. typhi , A. niger and C... |
|
T10561 |
BM-131246
|
|
Others
|
|
|
|
T0334 |
Rosiglitazone
|
BRL49653 |
Ferroptosis
,
TRP/TRPV Channel
,
PPAR
,
Autophagy
|
|
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer. |
|
T1622 |
Rosiglitazone maleate
|
BRL 49653C,BRL 49653 |
Ferroptosis
,
TRP/TRPV Channel
,
PPAR
,
Autophagy
|
|
Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. |
|
T38715 |
MSDC-0602K
|
MSDC-0602K,Azemiglitazone potassium |
PPAR
|
|
MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (... |
|
T8780 |
AMG131
|
INT-131,AMG-131,CHS 131 |
PPAR
|
|
AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin depende... |
|
T0214L |
Pioglitazone hydrochloride
|
U-72107E,AD 4833,U 72107A,Pioglitazone HCl |
Ferroptosis
,
PPAR
|
|
Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. |
|
T3989 |
SMI-16a
|
PIM1/2 Kinase Inhibitor VI |
Pim
|
|
SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM) while exhibiting little or no activity against... |
|
T0214 |
Pioglitazone
|
U 72107 |
Ferroptosis
,
PPAR
|
|
Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury. |
|
T0242 |
Sitagliptin
|
MK0431 |
Proteasome
,
DPP-4
,
Autophagy
|
|
Sitagliptin (MK0431), a new oral hypoglycemic (anti-diabetic drug), is a new dipeptidyl peptidase-4 (DPP-4) inhibitor. This enzyme-inhibiting drug is used either alone or in combination with metformin or thiazolidinedion... |
|
T61875 |
Rivoglitazone
|
|
|
|
Rivoglitazone is a thiazolidinedione-derivative PPARγ agonist for the treatment of type 2 diabetes mellitus. |
|
T30817 |
Cgp 19984
|
|
|
|
CGP 19984 is a thiazolidinedione derivative that inhibits luteinizing hormone secretion and has anti-tumor effects. |
|
T62576 |
Darglitazone Sodium
|
|
|
|
Darglitazone Sodium is a thiazolidinedione, a selective, orally active PPAR-γ (peroxisome proliferator-activated receptor) agonist, which can be used in the study of type II diabetes as it effectively controls glucose an... |
|
T69011 |
Lobeglitazone
|
|
|
|
Lobeglitazone, also known as CKD-501, is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat ce... |
|
T36180 |
Azelaoyl PAF
|
|
|
|
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ. One of these substances was recently isolated and pur... |
|
T37827 |
CAY10506
|
CAY10506 |
|
|
Anti-diabetic drugs of the thiazolidinedione (TZD) structural class as well as α-lipoic acid activate peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor that controls glucose metabolism ... |
|
T79621 |
TZ4M
|
|
|
|
TZ4M, a 2,4-thiazolidinedione (TZD)-based anti-ADV agent, exhibits neuroprotective effects and acetylcholinesterase (AChE) inhibition in human plasma. It enhances memory and cognitive function in adult rats within a scop... |
