|
T7530 |
PD146176
|
NSC168807 |
Ferroptosis
,
Lipoxygenase
,
Autophagy
|
|
PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology... |
|
T14690 |
BMS 433796
|
BMS-289948,BMS-299897 |
Beta Amyloid
|
|
BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease. |
|
T9253 |
CPFX4158
|
|
Antibacterial
|
|
CPFX4158 is a mannose deriviative and an antibacterial agent that is potentially useful in transgenic humanized- CEACAM6 mouse. |
|
T60086 |
TTBK1-IN-2
|
N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
Microtubule Associated
|
|
TTBK1-IN-2 (N-[4-(4-chlorophenoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine) is an inhibitor of Tau-Tubulin kinase (TTBK1) with IC50s of 0.24 and 4.22 µM. TTBK1-IN-2 reduces TDP-43 phosphorylation both in cell cultures ... |
|
T77342 |
GSK-3 inhibitor 3
|
|
GSK-3
,
Microtubule Associated
|
|
GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively.GSK-3 inhibitor 3 reduces the phosphorylation level of tau ... |
|
T11016 |
DGAT-1 inhibitor 2
|
|
Transferase
|
|
DGAT-1 inhibitor 2 is an effective DGAT-1 inhibitor; anti-obesity drug. Objective: DGAT-1 acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step of triglyceride s... |
|
T9518 |
Inarigivir ammonium
|
ORI-9020 ammonium,SB-9200 ammonium |
HBV
|
|
Inarigivir ammonium (SB-9200 ammonium) is a dinucleotide antiviral compound that significantly reduces HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir is an agonist of retinoic acid-inducible gene-I (... |
|
TP1541L |
BDC2.5 mimotope 1040-31 acetate
|
BDC2.5 mimotope 1040-31 acetate(329696-49-3 free base) |
Others
|
|
BDC2.5 mimotope 1040-31 acetate is a effectively agonistic peptide (mimotope) for diabetogenic T cell clone BDC2.5. It can stimulate BDC2.5 cells with cells showing good response to this mimotope. 1040-31 peptide is spec... |
|
T9901A-001 |
Relatlimab
|
BMS-986016 |
Others
|
|
Relatlimab(BMS-986016) is a monoclonal antibody targeting human anti-LAG-3, generated by immunization of transgenic mice with human immunoglobulin carrying recombinant LAG-3 protein.Relatlimab has a blocking effect, bloc... |
|
T35689 |
MTP 131 acetate
|
|
Others
|
|
MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... |
|
T32330 |
JWB1-84-1 3HCl
|
JWB1 84 1 3HCl,JWB1 84 1 trihydrochloride,JWB1-84-1 trihydrochloride,JWB1841 trihydrochloride |
|
|
JWB1-84-1 3HCl, as a neuroprotective agent, can act by improving cognitive performances in a transgenic mouse model of AD. |
|
T69664 |
Umibecestat HCl
|
|
|
|
Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD... |
|
T69540 |
MI-30
|
|
|
|
MI-30 is a SARS-CoV-2 Protease inhibitor (IC50 = 17.2 nM). In a transgenic mouse model of SARS-CoV-2 infection, oral or intraperitoneal treatment, MI-30 significantly reduced lung viral loads and lung lesions. |
|
T38279 |
C2-8
|
C2-8 |
|
|
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isola... |
|
T62198 |
AR524
|
|
|
|
AR524 is a transgenic inhibitor with higher inhibitory activity than the known transgenic inhibitor kifunensine. AR524 inhibits the formation of human malignant cell spheroids at low concentrations (10 μM). |
|
T32276 |
JAY2-22-33
|
JAY-2-22-33,JAY 2 22 33 |
|
|
JAY2-22-33, as a neuroprotective agent, can act by significantly reducing Aβ toxicity by delaying paralysis and improving cognitive performances in a transgenic mouse model of AD. |
|
T70059 |
ALT-946 HCl
|
|
|
|
ALT-946 HCl is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat. |
|
T78807 |
YIAD-0205
|
|
|
|
YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familial AD mutations [1]. |
|
T68794 |
ALT-946 free base
|
|
|
|
ALT-946 free base is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat. |
|
TP1541 |
BDC2.5 mimotope 1040-31
|
|
|
|
This is a effectively agonistic peptide (mimotope) for diabetogenic T cell clone BDC2.5. It can stimulate BDC2.5 cells with cells showing good response to this mimotope. 1040-31 peptide is specific for BDC2.5 TCR Tg+ (tr... |
|
TP1855 |
Moth Cytochrome C (MCC) (88-103)
|
Moth Cytochrome C (MCC) 88-103 |
|
|
Moth Cytochrome C (MCC) (88-103), derived from the carboxyl terminus of moth cytochrome c, induces positive selection of TCR transgenic thymocytes.This peptide is derived from the carboxyl terminus of moth cytochrome c. ... |
|
T69524 |
MI-09
|
|
|
|
MI-09 is a SARS-CoV-2 Protease inhibitor (IC50 = 15.2 nM). In a transgenic mouse model of SARS-CoV-2 infection, oral or intraperitoneal treatment with MI-09 significantly reduced lung viral loads and lung lesions. |
|
T70151 |
MeTC7
|
|
|
|
MeTC7 is a VDR antagonist, which can be synthesized from 7-dehydrocholesterol (6) in two steps, inhibits VDR selectively, suppresses the viability of cancer cell-lines, and reduces the growth of the spontaneous transgen... |
|
T40132 |
Insulin β Chain Peptide (15-23)
|
|
|
|
Insulin β Chain Peptide (15-23), also referred to as INS, is an insulin-derived peptide that is specifically recognized by islet-associated T cells. The tetramer of Insulin β Chain Peptide (15-23) effectively stained the... |
|
T74065 |
Nifurpirinol
|
|
|
|
Nifurpirinol (P-7138), a nitroaromatic antibiotic, functions as a novel substrate for the bacterial nitroreductase (NTR) enzyme. Compared to Metronidazole, it serves as a more potent proagent for initiating cell ablation... |
|
TP1954 |
PHM-27 (human)
|
|
|
|
Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets di... |
|
T40059 |
Nicotinamide riboside tartrate
|
|
|
|
Nicotinamide riboside tartrate (NRT) is an oral NAD+ precursor that raises NAD+ levels, activates SIRT1 and SIRT3, and serves as a vitamin B3 (niacin) source. NRT also improves oxidative metabolism and protects against m... |
|
T82908 |
BDC2.5 mimotope 1040-31 TFA
|
|
|
|
BDC2.5 mimotope 1040-31 TFA, a specific agonistic peptide for the diabetogenic T cell clone BDC2.5, exhibits strong reactivity with BDC2.5 T-cell receptor (TCR) transgenic (Tg)+ T cells [1] [2]. |
|
T71174 |
PBT434 HBr
|
|
|
|
PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neur... |
|
T78426 |
MCAAD-3
|
|
|
|
MCAAD-3, a near-infrared Aβ imaging probe, exhibits blood-brain barrier permeability and strong affinity for Aβ polymers (Ki >106 nM). It successfully labels Aβ plaques in the brains of transgenic mice [1]. |
|
T37367 |
Amyloid-β (1-42) Peptide (trifluoroacetate salt)
|
|
|
|
Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of ne... |
|
T36234 |
5(Z),11(Z),14(Z)-Eicosatrienoic Acid
|
|
|
|
5(Z),11(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid found in various natural sources including maritime pine (Pinus pinaster) seed oil (MPSO), gymnospermae leaves and seeds, and freshwater gastropods. A ... |
|
TP1752 |
GP(33-41)
|
|
|
|
GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2Db molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM. GP33-41 Epitop... |
|
T33766 |
OAB-14
|
OAB 14,OAB14 |
|
|
OAB-14 is a Bexarotene derivative that improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. OAB-14 effectively ameliorates the dysfunction of the e... |
|
T71327 |
Paraxanthine-d6
|
|
|
|
Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the c... |
|
T71211 |
Rizatriptan-d6 benzoate salt
|
|
|
|
Rizatriptan-d6 is intended for use as an internal standard for the quantification of rizatriptan by GC- or LC-MS. Rizatriptan is an agonist of the serotonin
receptor subtypes 5-HT1B and 5-HT1D. It is selective for 5-H... |
|
T82907 |
BDC2.5 Mimotope 1040-63
|
|
|
|
BDC2.5 Mimotope 1040-63 is a biologically active peptide employed in the investigation of type 1 diabetes (T1D), an autoimmune disease where T cells induce destruction of pancreatic islet β cells. This mimotope, originat... |
|
T38204 |
GAT229
|
|
|
|
GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) and the S-(-) enantiomer of the CB1 modulator GAT211. It does not activate the receptor on its own but enhances the binding and activity of CB ago... |
|
T35813 |
CAY10592
|
|
|
|
Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharm... |
|
T35633 |
Pinolenic Acid ethyl ester
|
|
|
|
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime... |
|
T35632 |
Pinolenic Acid
|
|
|
|
Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime... |
|
T63902 |
XP-524
|
|
|
|
XP-524 is a potent inhibitor of BET and EP300. XP-524 has significant tumouricidal effects in vivo, preventing KRAS-induced tumour transformation in vivo and prolonging survival in two aggressive PDAC transgenic mouse mo... |
|
T36639 |
Donecopride (fumarate hydrate)
|
|
|
|
Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= ... |
|
T36499 |
CuATSM
|
|
|
|
The metallo-protein Cu/Zn-superoxide dismutase (SOD1) is a ubiquitous enzyme responsible for scavenging superoxide radicals. Mutations in SOD1, which alter its metal binding capacity and can result in protein misfolding ... |
|
T35855 |
AAA
|
|
|
|
AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-... |
|
T36188 |
Ceramide Phosphoethanolamines (bovine)
|
|
|
|
Ceramide phosphoethanolamine (CPE) is an analog of sphingomyelin that contains ethanolamine rather than choline as the head group. It is the principal membrane phospholipid in invertebrates such as Drosophila, which lack... |
|
T38218 |
1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
|
|
|
|
1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC is a phospholipid in biological membranes containing stearic acid and docosahexaenoic acid at the sn-1 and sn-2 positions, respectively. It has been used to study the organiza... |
|
T37791 |
A-971432
|
|
|
|
A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively). It inhibits forskolin-induced cAMP production in CHO cel... |
|
T36521 |
Alaproclate (hydrochloride)
|
|
|
|
Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s =... |
|
T83955 |
MOMBA
|
|
|
|
MOMBA is a selective orthosteric agonist specifically targeting engineered human free fatty acid 2 (hFFA2) receptors, particularly those modified as designer receptors activated by designer drugs (DREADD). It demonstrate... |
