ペプチド
抗体
色素試薬
PROTAC
バーチャルスクリーニング
TargetMolキット
Cell Counting Kit-8 (CCK-8)
Inhibitor Cocktails
天然化合物
フェノール類
アルカロイド類
フラボノイド類
阻害剤
血管新生
アポトーシス
オートファジー
細胞周期・チェックポイント
クロマチン・エピジェネティック
細胞骨格シグナル
DNA損傷・DNA修復
内分泌・ホルモン
GPCR/Gタンパク質
免疫・炎症
JAK・STATシグナル
| Cat. No. | 製品名 | CAS No. | Purity | Chemical Structure |
|---|---|---|---|---|
| T2083 | PI-3065 | 955977-50-1 | 98% |
|
| PI-3065 is a novel potent and selective PI3K p110δ inhibitor. | ||||
| T8637 | DMNB | 20357-25-9 | 98% |
|
| 6-Nitroveratraldehyde is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) pathway ... | ||||
| T6276 | KU-57788 | 503468-95-9 | 98% |
|
| NU7441 (KU-57788) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM). | ||||
| T3541 | CC-115 | 1228013-15-7 | 98% |
|
| CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). | ||||
| T1826 | PI3K-IN-1 | 1349796-36-6 | 98% |
|
| Voxtalisib (SAR245409, XL765)Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR. | ||||
| T13017 | STL127705 | 1326852-06-5 | 98% |
|
| STL127705 is a inhibitor of Ku 70/80 heterodimer protein(Ku70/80-DNA interaction, with an IC50 of 3.5 μM). STL127705 also inhibits Ku-dependent activation of DNA... | ||||
| T11067 | VX-984 | 1476074-39-1 | 98% |
|
| VX-984 is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted ... | ||||
| T7122 | AZD-7648 | 2230820-11-6 | 98% |
|
| AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity. | ||||
| T6319 | OSI-027 | 936890-98-1 | 98% |
|
| OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3... | ||||
| T2461 | PIK-90 | 677338-12-4 | 98% |
|
| PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) . | ||||
| T2287 | PIK-75 hydrochloride | 372196-77-5 | 98% |
|
| PIK-75 Hydrochloride is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibits... | ||||
| T3986 | SF2523 | 1174428-47-7 | 98% |
|
| SF2523 is a highly selective and potent inhibitor. | ||||
| T2667 | PIK-75 | 372196-67-3 | 98% |
|
| PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM). | ||||
| T25399 | ETP-45658 | 1198357-79-7 | 98% |
|
| ETP-45658 is an inhibitor of PI3-kinase, also inhibiting DNA-PK and mTOR. | ||||
| T6557 | KU-0060648 | 881375-00-4 | 98% |
|
| KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of... | ||||
| T6143 | PI-103 | 371935-74-9 | 98% |
|
| PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK). | ||||
| T9498 | BAY-8400 | T9498 | 98% |
|
| BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in combinat... | ||||
| T9760 | IC 86621 | 404009-40-1 | 98% |
|
| IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitu... | ||||
| T7014 | Voxtalisib | 934493-76-2 | 98% |
|
| Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2. | ||||
| T6045 | Torin 1 | 1222998-36-8 | 98% |
|
| Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K. | ||||
