| T8637 |
DMNB
|
20357-25-9
|
|
|
|
DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 15 μM, an enzyme involved in the non-homologous end-joining (NHEJ) p...
|
| T2433 |
NU 7026
|
154447-35-5
|
100%
|
|
|
NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition aga...
|
| T3541 |
CC-115
|
1228013-15-7
|
86.79%
|
|
|
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
|
| T1826 |
PI3K-IN-1
|
1349796-36-6
|
97.07%
|
|
|
PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.
|
| T13017 |
STL127705
|
1326852-06-5
|
97.41%
|
|
|
STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor and inhibits Ku70/80-DNA interaction with IC50 of 3.5 μM. STL127705 inhibits the activa...
|
| T11067 |
VX-984
|
1476074-39-1
|
97.65%
|
|
|
VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ an...
|
| T7122 |
AZD-7648
|
2230820-11-6
|
98%
|
|
|
AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.
|
| T6319 |
OSI-027
|
936890-98-1
|
98%
|
|
|
OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTO...
|
| T2083 |
PI-3065
|
955977-50-1
|
98%
|
|
|
PI-3065 is a novel potent and selective PI3K p110δ inhibitor.
|
| T2461 |
PIK-90
|
677338-12-4
|
98%
|
|
|
PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
|
| T2287 |
PIK-75 hydrochloride
|
372196-77-5
|
98%
|
|
|
PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also pote...
|
| T3986 |
SF2523
|
1174428-47-7
|
98.06%
|
|
|
SF2523 is a highly selective and potent inhibitor.
|
| T25399 |
ETP-45658
|
1198357-79-7
|
99.13%
|
|
|
ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DN...
|
| T6557 |
KU-0060648
|
881375-00-4
|
99.21%
|
|
|
KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of...
|
| T6143 |
PI-103
|
371935-74-9
|
99.3%
|
|
|
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).
|
| T9498 |
BAY-8400
|
T9498
|
99.32%
|
|
|
BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in combinat...
|
| T9760 |
IC 86621
|
404009-40-1
|
99.33%
|
|
|
IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitu...
|
| T7014 |
Voxtalisib
|
934493-76-2
|
99.36%
|
|
|
Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
|
| T6045 |
Torin 1
|
1222998-36-8
|
99.38%
|
|
|
Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
|
| T3351 |
Onatasertib
|
1228013-30-6
|
99.41%
|
|
|
Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the i...
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