DUB

Deubiquitinating enzymes (DUBs), also known as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolases, ubiquitin isopeptidases, are a large group of proteases that cleave ubiquitin from proteins and other molecules. Ubiquitin is attached to proteins in order to regulate the degradation of proteins via the proteasome and lysosome; coordinate the cellular localisation of proteins; activate and inactivate proteins; and modulate protein-protein interactions.DUBs can reverse these effects by cleaving the peptide or isopeptide bond between ubiquitin and its substrate protein. In humans there are nearly 100 DUB genes, which can be classified into two main classes: cysteine proteases and metalloproteases. The cysteine proteases comprise ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), Machado-Josephin domain proteases (MJDs) and ovarian tumour proteases (OTU). The metalloprotease group contains only the Jab1/Mov34/Mpr1 Pad1 N-terminal+ (MPN+) (JAMM) domain proteases.

Cat. No.	製品名	CAS No.	Purity
T8464	RA-9	919091-63-7	98%
T8464	RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 ...
T9217	USP7-IN-8	2009273-60-1	98%
T9217	Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. US...
T4634	GNE-6776	2009273-71-4	98%
T4634	GNE-6776 is a selective USP7 inhibitor.
T7685	USP25/28 inhibitor AZ1	2165322-94-9	98%
T7685	USP25/28 inhibitor AZ1 (AZ1) is an inhibitor of ubiquitin specific protease (USP) 25/28
T12024	MF-094	2241025-68-1	98%
T12024	MF-094 is a potent and selective inhibitor of USP30 (IC50 of 120 nM).
T11110	DUB-IN-1	924296-18-4	98%
T11110	DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
T9375	IU1-248	2307472-03-1	98%
T9375	IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].
T11112	DUB-IN-3	924296-17-3	98%
T11112	DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c. The IC50 for USP8 is 0.56 μM.
T3555	ML364	1991986-30-1	98%
T3555	ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.
T15729	LDN-91946	439946-22-2	98%
T15729	LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).
T6697	TCID	30675-13-9	98%
T6697	TCID(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
T14852	C527	192718-06-2	98%
T14852	C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
T1924	LDN-57444	668467-91-2	98%
T1924	LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) .
T1902	BAY 11-7082	19542-67-7	98%
T1902	BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21.
T1932	B-AP15	1009817-63-3	98%
T1932	B-AP15(NSC687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the ...
T6107	IU1	314245-33-5	98%
T6107	IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.
T3088	N-Ethylmaleimide	128-53-0	98%
T3088	N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies.
T11485	GSK2643943A	2449301-27-1	98%
T11485	GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.
T11209	EOAI3402143	1699750-95-2	98%
T11209	EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp5/Usp24 andUsp9x.
T3089	6-Thioguanine	154-42-7	98%
T3089	Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.