Powder: -20°C for 3 years | In solvent: -80°C for 1 year
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 7,500 | |||
5 mg | 在庫あり | ¥ 15,500 | |||
10 mg | 在庫あり | ¥ 27,000 | |||
25 mg | 在庫あり | ¥ 45,000 | |||
50 mg | 在庫あり | ¥ 66,500 | |||
100 mg | 在庫あり | ¥ 98,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 17,000 |
説明 | iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity). |
ターゲット&IC50 | Wnt responsive STF16 luciferase:40.3 nM |
In vitro | iCRT14 can interfere with TCF binding to DNA in addition to its ability to influence TCF-β-cat interaction. iCRT14 (10, 25, 50 μM) effectively inhibits cell proliferation in BT-549 cells in a dose- and time-dependent manner but is still less potent than iCRT3. |
In vivo | CRT14 (50 mg/kg, i.p.) markedly decreases CycD1, proliferation of the tumors in HCT116 xenografts. |
分子量 | 375.44 |
分子式 | C21H17N3O2S |
CAS No. | 677331-12-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 28 mg/mL (74.6 mM)
You can also refer to dose conversion for different animals. 詳細
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iCRT 14 677331-12-3 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin iCRT14 iCRT-14 Wnt Inhibitor inhibit inhibitor