| T60220 |
ROS kinases-IN-1
|
370096-57-4
|
97.36%
|
|
|
ROS kinases-IN-1 is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity.
|
| T11254 |
F-1
|
2244775-31-1
|
97.66%
|
|
|
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppress...
|
| T1661 |
Crizotinib
|
877399-52-5
|
99.35%
|
|
|
Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
|
| T3455 |
Merestinib
|
1206799-15-6
|
99.56%
|
|
|
Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. Merestinib...
|
| T3678 |
Entrectinib
|
1108743-60-7
|
99.61%
|
|
|
Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1....
|
| T74671 |
ROS kinases-IN-2
|
687576-28-9
|
99.66%
|
|
|
ROS kinases-IN-2 is a potent ROS kinase inhibitor with an inhibition rate of 21.53% measured at 10 μM.ROS kinases-IN-2 has potential anticancer activity and can ...
|
| T8399 |
Crizotinib hydrochloride
|
1415560-69-8
|
99.67%
|
|
|
Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
|
| T77762 |
ROS-generating agent 1
|
2369030-41-9
|
99.67%
|
|
|
Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR. ROS-generating agent 1 reduces intracellular T...
|
| TMS1743 |
Salvigenin
|
19103-54-9
|
99.67%
|
|
|
Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects.
|
| T4071 |
Repotrectinib
|
1802220-02-5
|
99.86%
|
|
|
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respec...
|
| T38995 |
Taletrectinib free base
|
1505514-27-1
|
99.87%
|
|
|
Taletrectinib free base (AB-106 free base) is a novel potent, selective and orally active ROS1/NTRK inhibitor.Taletrectinib free base has potent inhibitory effec...
|
| T3061 |
Lorlatinib
|
1454846-35-5
|
99.93%
|
|
|
Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1...
|
| T21482 |
Uniconazole
|
83657-22-1
|
99.94%
|
|
|
Uniconazole is a plant growth regulator that inhibit cytochrome P450 707As (Ki=68 nM). CYP707As is a major ABA catabolic enzyme that catabolize Abscisic acid, ac...
|
| T22318 |
Taletrectinib
|
1505515-69-4
|
99.96%
|
|
|
Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980...
|
| T83048 |
Anti-inflammatory agent 64
|
|
98%
|
|
|
Anti-inflammatory agent 64 (compound 4b) exhibits antioxidant and anti-inflammatory activities, effectively inhibiting the secretion of IL-6 and TNF-α while also...
|
| T82171 |
HS-291
|
|
98%
|
|
|
HS-291 is a HtpG inhibitor targeting Borrelia burgdorferi (Bb), composed of BX-2819 (high affinity for Bb HtpG), a PEG linker, and Verteporfin (a photoactive tox...
|
| T79363 |
APG-2449
|
2196186-84-0
|
98%
|
|
|
APG-2449 is an orally active inhibitor targeting ALK, ROS1, and FAK, demonstrating antitumor efficacy in mouse models of non-small cell lung cancer (NSCLC) [1].
|
| T79159 |
Methyl 12-methyltridecanoate
|
5129-58-8
|
98%
|
|
|
Methyl 12-methyltridecanoate ((R)-betaxolol hydrochloride), a biosurfactant derived from Brevibacterium casei LS14, enhances the biocompatibility of functionaliz...
|
