Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
説明 | Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM) |
ターゲット&IC50 | ALK:20 nM , c-Met:8 nM |
In vitro | Crizotinib hydrochloride(PF-2341066)potently inhibited NPM-ALK phosphorylation in Karpas299 or SU-DHL-1 ALCL cells (mean IC(50) value, 24 nmol/L).?In biochemical and cellular screens, PF-2341066 was shown to be selective for c-Met and ALK at pharmacologically relevant concentrations across a panel of >120 diverse kinases.?PF-2341066 potently inhibited cell proliferation, which was associated with G(1)-S-phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC(50) values, approximately 30 nmol/L) but not ALK-negative lymphoma cells[1]. |
別名 | PF-02341066 hydrochloride |
分子量 | 486.8 |
分子式 | C21H23Cl3FN5O |
CAS No. | 1415560-69-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.9 mg/mL (10.07 mM)
H2O: 50 mg/mL (102.71 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Crizotinib hydrochloride 1415560-69-8 Angiogenesis Autophagy Immunology/Inflammation Tyrosine Kinase/Adaptors c-Met/HGFR ROS ALK ROS Kinase Crizotinib Hydrochloride PF02341066 Hydrochloride CD246 PF-02341066 PF 02341066 Hydrochloride ALK tyrosine kinase receptor Anaplastic lymphoma kinase (ALK) PF02341066 PF 02341066 Crizotinib Cluster of differentiation 246 Inhibitor PF-02341066 Hydrochloride inhibit Anaplastic lymphoma kinase PF-02341066 hydrochloride inhibitor