Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 24,500 | |||
5 mg | 在庫あり | ¥ 52,500 | |||
10 mg | 在庫あり | ¥ 85,500 | |||
25 mg | 在庫あり | ¥ 144,500 | |||
50 mg | 在庫あり | ¥ 206,000 | |||
100 mg | 在庫あり | ¥ 280,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 63,500 |
説明 | (Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer. |
ターゲット&IC50 | EGFR:0.26 nM |
In vitro | (Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M[1]. |
In vivo | The combination of osimertinib and JBJ-04-125-02 is a significantly more effective treatment approach than either agent alone[1]. |
動物実験 | Ba/F3, H1975, H3255GR and H3255DR cells were treated with increasing concentrations of inhibitors for 72 hours and growth or the inhibition of growth was assessed by MTS assay according to previously established methods. |
別名 | JBJ-04-125-02 |
分子量 | 543.61 |
分子式 | C29H26FN5O3S |
CAS No. | 2140807-05-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (101.17 mM)
You can also refer to dose conversion for different animals. 詳細
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(Rac)-JBJ-04-125-02 2140807-05-0 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR Allosteric anti-proliferation HER1 inhibit JBJ-04-125-02 ErbB-1 (Rac)JBJ0412502 Inhibitor racemate Epidermal growth factor receptor anti-tumor (Rac) JBJ 04 125 02 T790M-mutant inhibitor