Powder: -20°C for 3 years | In solvent: -80°C for 1 year
10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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10 mg | 在庫あり | ¥ 9,500 | |||
25 mg | 在庫あり | ¥ 15,500 | |||
50 mg | 在庫あり | ¥ 21,000 | |||
100 mg | 在庫あり | ¥ 27,000 |
説明 | 10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism. |
In vitro | 10,12-Tricosadiynoic acid-CoA rapidly inhibits ACOX1 activity in a time- and concentration-dependent manner. The activity of ACOX1 decreases by nearly 95% after 5 min of incubation with 10 eq of 10,12-Tricosadiynoic acid-CoA. ACOX1 activity is inhibited only if free 10,12-Tricosadiynoic Acid is activated as the CoA thioester, the substrate form. The inhibition of ACOX1 by 10,12-Tricosadiynoic acid-CoA is irreversible. And the kinetics parameters KI and kinact are calculated to be 680 nm and 3.18/min, respectively. |
In vivo | 10,12-Tricosadiynoic acid (100 μg/kg; oral gavage; daily; for 8 weeks; male Wistar rats) treatment increases hepatic mitochondrial fatty acid oxidation (FAO) via activation of the SIRT1-AMPK pathway and proliferator activator receptor α and reduces hydrogen peroxide accumulation in high fat diet-fed rats, which significantly decreases hepatic lipid and ROS contents, reduces body weight gain, and decreases serum triglyceride and insulin levels. |
動物実験 | Animal Model: Male Wistar rats (210-230 g) fed with high-fat diet. Dosage: 100 μg/kg. Administration: Oral gavage; daily; for 8 weeks |
別名 | TDA, TCDA |
分子量 | 346.55 |
分子式 | C23H38O2 |
CAS No. | 66990-30-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.75 mg/mL (7.94 mM)
You can also refer to dose conversion for different animals. 詳細
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10,12-Tricosadiynoic acid 66990-30-5 Metabolism Acyltransferase ROS mono- acylglycerol acyltransferase 10,12Tricosadiynoic acid fatty Diacylglycerol acyltransferase TDA SIRT1-AMPK Diglyceride acyltransferase metabolic mitochondrial oxidation insulin 10,12 Tricosadiynoic acid inhibit triglyceride Inhibitor acyl-CoA:cholesterol acyltransferase TCDA acid inhibitor