Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells
説明 | ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells |
ターゲット&IC50 | KRas (G12C):2.5 μM |
In vitro | ARS-853 decreases phosphorylation of c-RAF, ERK, and Akt. ARS853 inhibits proliferation of six lung cancer cell lines containing the K-RASG12C mutation, including H358 cells (IC50 = 2.5 μM), but does not inhibit proliferation of PC-9 cells, which contain wild-type K-RAS[1]. |
分子量 | 432.94 |
分子式 | C22H29ClN4O3 |
CAS No. | 1629268-00-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 71 mg/mL (164.00 mM)
You can also refer to dose conversion for different animals. 詳細
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ARS-853 1629268-00-3 Apoptosis GPCR/G Protein MAPK Raf Ras KRAS cancer mutant state inhibit Inhibitor ARS853 inactive selective,covalent G12C ARS 853 inhibitor