Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).
説明 | Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2). |
ターゲット&IC50 | JAK2:803 nM, JAK1:29 nM, TYK2:1253 nM |
In vitro | Abrocitinib inhibits IFN-stimulated phosphorylation of STAT1 in human whole blood (HWB), IFNα-stimulated phosphorylation of STAT3, as well as pSTAT5 in CD34+ spiked into HWB (JAK2), with IC50s of 163, 189 nM, 7.178 μM, respectively. |
In vivo | In the rat adjuvant-induced arthritis model, Abrocitinib (5, 15, 50 mg/kg, p.o., daily for 7 days) significantly reduces paw swelling. |
別名 | PF-04965842 |
分子量 | 323.41 |
分子式 | C14H21N5O2S |
CAS No. | 1622902-68-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (371.05 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Abrocitinib 1622902-68-4 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK inhibit PF04965842 Inhibitor PF-04965842 Janus kinase PF 04965842 inhibitor