Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
50 mg | 在庫あり | ¥ 10,000 | |||
100 mg | 在庫あり | ¥ 15,500 | |||
200 mg | 在庫あり | ¥ 22,500 | |||
500 mg | 在庫あり | ¥ 43,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions. |
ターゲット&IC50 | RARβ:2.3 nM (AC50), RARγ:9.3 nM (AC50), RARα:22 nM (AC50) |
In vitro | In rhino mice, Adapalene reduces the quantity of comedonal melanin in the epidermis and increases epidermal thickness. Within both normal skin and acne explants, Adapalene decreases the expression of TLR-2 (TLR-2) and IL-10 (IL-10). By upregulating CD1d expression and downregulating the IL-10 expression in keratinocytes, Adapalene modulates the epidermal immune system. This action enhances the interaction between dendritic cells and T lymphocytes, augmenting antimicrobial activity against Propionibacterium acnes. |
In vivo | In colorectal cancer cell lines CC-531, HT-29, and LOVO, as well as in human foreskin fibroblasts, Adapalene induces caspase-3 activity in tumor cells, inhibits DNA synthesis in a time- and dose-dependent manner, and triggers apoptosis. |
別名 | CD271 |
分子量 | 412.52 |
分子式 | C28H28O3 |
CAS No. | 106685-40-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10.3 mg/mL (25 mM)
You can also refer to dose conversion for different animals. 詳細
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Adapalene 106685-40-9 Apoptosis Autophagy Metabolism Retinoid Receptor RAR/RXR GOT1 acne RARα Retinoid X receptors CD 271 Inhibitor RARγ tumor retinoid RAR CD-271 Retinoic acid receptors CD271 RARβ inhibit inhibitor