Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 12,000 | |||
5 mg | 在庫あり | ¥ 24,500 | |||
10 mg | 在庫あり | ¥ 39,000 | |||
25 mg | 在庫あり | ¥ 60,500 | |||
50 mg | 在庫あり | ¥ 102,500 | |||
100 mg | 在庫あり | ¥ 165,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 28,500 |
説明 | BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM. |
ターゲット&IC50 | SMYD2:27 nM |
In vitro | BAY-598 treatment blocked in vitro methylation of MAPKAPK3 by SMYD2 but had no activity against the SMYD2-related KMT SMYD3, which methylated its substrate, MAP3K2, irrespective of the presence of BAY-598.?BAY-598 treatment reduced the growth of Kras;p53 mutant PDAC cells after 9 d in culture but had little impact on the growth of Kras;p53;Smyd2 mutant cells , further supporting the specificity of this small molecule inhibitor of SMYD2 as well as a role for SMYD2 in promoting the growth of PDAC cells[1]. |
分子量 | 525.34 |
分子式 | C22H20Cl2F2N6O3 |
CAS No. | 1906919-67-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (237.94 mM)
You can also refer to dose conversion for different animals. 詳細
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BAY-598 1906919-67-2 Chromatin/Epigenetic Histone Methyltransferase BAY 598 Inhibitor BAY598 inhibit inhibitor